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Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor.
Best Pract Res Clin Gastroenterol. 2005 Oct; 19(5):699-704.BP

Abstract

It has become increasingly clear that duodenal gastrinomas are the most common cause of Zollinger-Ellison syndrome (ZES). However, attempts to find these tumors before and during surgery for ZES have had limited success until duodenotomy (opening the duodenum) was described. The routine use of duodenotomy in patients with non-familial gastrinoma increases the number of duodenal tumors found, and the immediate and long-term cure-rate. The increase in cure-rate appears to be secondary to increased detection of small, previously undetectable duodenal gastrinomas. Duodenotomy detects small tumors (<1 cm) in the proximal duodenum. It does not detect more duodenal gastrinomas per patient, nor does it detect tumors in unusual duodenal locations. Duodenotomy decreases the death-rate associated with these tumors. However, it has not affected the rate of development of liver metastases. Duodenotomy is a critical method to find duodenal gastrinomas. It should be routinely performed in all surgery to find and remove gastrinoma for cure of ZES.

Authors+Show Affiliations

Department of Surgery, Stanford University Medical Center, 300 Pasteur Drive, Room H3651, Stanford, CA 94305-5641, USA. janorton@stanford.edu

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

16253894

Citation

Norton, Jeffrey A.. "Surgery and Prognosis of Duodenal Gastrinoma as a Duodenal Neuroendocrine Tumor." Best Practice & Research. Clinical Gastroenterology, vol. 19, no. 5, 2005, pp. 699-704.
Norton JA. Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor. Best Pract Res Clin Gastroenterol. 2005;19(5):699-704.
Norton, J. A. (2005). Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor. Best Practice & Research. Clinical Gastroenterology, 19(5), 699-704.
Norton JA. Surgery and Prognosis of Duodenal Gastrinoma as a Duodenal Neuroendocrine Tumor. Best Pract Res Clin Gastroenterol. 2005;19(5):699-704. PubMed PMID: 16253894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor. A1 - Norton,Jeffrey A, PY - 2005/10/29/pubmed PY - 2006/1/28/medline PY - 2005/10/29/entrez SP - 699 EP - 704 JF - Best practice & research. Clinical gastroenterology JO - Best Pract Res Clin Gastroenterol VL - 19 IS - 5 N2 - It has become increasingly clear that duodenal gastrinomas are the most common cause of Zollinger-Ellison syndrome (ZES). However, attempts to find these tumors before and during surgery for ZES have had limited success until duodenotomy (opening the duodenum) was described. The routine use of duodenotomy in patients with non-familial gastrinoma increases the number of duodenal tumors found, and the immediate and long-term cure-rate. The increase in cure-rate appears to be secondary to increased detection of small, previously undetectable duodenal gastrinomas. Duodenotomy detects small tumors (<1 cm) in the proximal duodenum. It does not detect more duodenal gastrinomas per patient, nor does it detect tumors in unusual duodenal locations. Duodenotomy decreases the death-rate associated with these tumors. However, it has not affected the rate of development of liver metastases. Duodenotomy is a critical method to find duodenal gastrinomas. It should be routinely performed in all surgery to find and remove gastrinoma for cure of ZES. SN - 1521-6918 UR - https://www.unboundmedicine.com/medline/citation/16253894/Surgery_and_prognosis_of_duodenal_gastrinoma_as_a_duodenal_neuroendocrine_tumor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6918(05)00084-3 DB - PRIME DP - Unbound Medicine ER -