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Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH.
Eur J Clin Nutr. 2005 Nov; 59 Suppl 2:S42-7.EJ

Abstract

OBJECTIVE

To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc.

DESIGN

A multicentre prospective intervention study employing a randomised double-blind design.

SETTING

Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy).

PARTICIPANTS

In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study.

METHODS

Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser.

RESULTS

In all centres, men had a significantly (P < 0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P < 0.0001). A high fat intake (from 36 to 40% of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r = 0.12, P < 0.05) or red blood cell zinc (r = 0.12, P < 0.01) and with erythrocyte folates and red blood cell zinc (r = 0.11, P < 0.05).

CONCLUSIONS

There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, alpha-tocopherol and folate appeared adequate.

Authors+Show Affiliations

Polito A
National Institute for Food and Nutrition Research, Human Nutrition Unit, Rome, Italy. polito@inran.it
Intorre F
No affiliation info available
Andriollo-Sanchez M
No affiliation info available
Azzini E
No affiliation info available
Raguzzini A
No affiliation info available
Meunier N
No affiliation info available
Ducros V
No affiliation info available
O'Connor JM
No affiliation info available
Coudray C
No affiliation info available
Roussel AM
No affiliation info available
Maiani G
No affiliation info available

MeSH

Age FactorsAgedAgingChromatography, High Pressure LiquidDiet RecordsDouble-Blind MethodEuropeFemaleFolic AcidHumansLuminescent MeasurementsMaleMiddle AgedNutrition SurveysNutritional StatusProspective StudiesReference ValuesSex FactorsVitamin AVitamin E

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16254580

Citation

Polito, A, et al. "Estimation of Intake and Status of Vitamin A, Vitamin E and Folate in Older European Adults: the ZENITH." European Journal of Clinical Nutrition, vol. 59 Suppl 2, 2005, pp. S42-7.
Polito A, Intorre F, Andriollo-Sanchez M, et al. Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH. Eur J Clin Nutr. 2005;59 Suppl 2:S42-7.
Polito, A., Intorre, F., Andriollo-Sanchez, M., Azzini, E., Raguzzini, A., Meunier, N., Ducros, V., O'Connor, J. M., Coudray, C., Roussel, A. M., & Maiani, G. (2005). Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH. European Journal of Clinical Nutrition, 59 Suppl 2, S42-7.
Polito A, et al. Estimation of Intake and Status of Vitamin A, Vitamin E and Folate in Older European Adults: the ZENITH. Eur J Clin Nutr. 2005;59 Suppl 2:S42-7. PubMed PMID: 16254580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH. AU - Polito,A, AU - Intorre,F, AU - Andriollo-Sanchez,M, AU - Azzini,E, AU - Raguzzini,A, AU - Meunier,N, AU - Ducros,V, AU - O'Connor,J M, AU - Coudray,C, AU - Roussel,A M, AU - Maiani,G, PY - 2005/10/29/pubmed PY - 2006/3/4/medline PY - 2005/10/29/entrez SP - S42 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 Suppl 2 N2 - OBJECTIVE: To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc. DESIGN: A multicentre prospective intervention study employing a randomised double-blind design. SETTING: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). PARTICIPANTS: In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study. METHODS: Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser. RESULTS: In all centres, men had a significantly (P < 0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P < 0.0001). A high fat intake (from 36 to 40% of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r = 0.12, P < 0.05) or red blood cell zinc (r = 0.12, P < 0.01) and with erythrocyte folates and red blood cell zinc (r = 0.11, P < 0.05). CONCLUSIONS: There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, alpha-tocopherol and folate appeared adequate. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16254580/Estimation_of_intake_and_status_of_vitamin_A_vitamin_E_and_folate_in_older_European_adults:_the_ZENITH_ DB - PRIME DP - Unbound Medicine ER -