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Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study.
Eur J Clin Nutr. 2005 Nov; 59 Suppl 2:S53-7.EJ

Abstract

OBJECTIVE

This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status.

DESIGN

A multicentre prospective intervention study employing a randomised double blind design.

SETTING

Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy).

INTERVENTIONS

BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in Clermont-Ferrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n = 387). BMR was measured by indirect calorimetry. Fat-free mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point.

RESULTS

Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (-7% P < 0.01). A negative correlation between BMR and age (men, r = -0.64; women, r = -0.62; both P < 0.0001) was observed: BMR was significantly (P < 0.000001) lower in Italian elderly volunteers (4.03+/-0.46 kJ/min and 3.29+/-0.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.84+/-0.45 kJ/min and 3.87+/-0.38 kJ/min for men and women, respectively), even after adjustment for FFM (-12%). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (TT4) concentrations were lowest in middle-aged population (-10%, P < 0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r = -0.12, P < 0.02, slope -0.026).

CONCLUSIONS

The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences.

Authors+Show Affiliations

Meunier N
Centre de Recherche en Nutrition Humaine d'Auvergne, Unité des Maladies Mé taboliques et Micronutrients, INRA, Clermont-Ferrand/Theix, France.
Beattie JH
No affiliation info available
Ciarapica D
No affiliation info available
O'Connor JM
No affiliation info available
Andriollo-Sanchez M
No affiliation info available
Taras A
No affiliation info available
Coudray C
No affiliation info available
Polito A
No affiliation info available

MeSH

Age FactorsAgedAgingAnalysis of VarianceBasal MetabolismBody CompositionCalorimetry, IndirectDouble-Blind MethodEuropeFemaleHumansLuminescent MeasurementsMaleMiddle AgedNutrition SurveysProspective StudiesSex FactorsSkinfold ThicknessThyroid HormonesZinc

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

16254583

Citation

Meunier, N, et al. "Basal Metabolic Rate and Thyroid Hormones of Late-middle-aged and Older Human Subjects: the ZENITH Study." European Journal of Clinical Nutrition, vol. 59 Suppl 2, 2005, pp. S53-7.
Meunier N, Beattie JH, Ciarapica D, et al. Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study. Eur J Clin Nutr. 2005;59 Suppl 2:S53-7.
Meunier, N., Beattie, J. H., Ciarapica, D., O'Connor, J. M., Andriollo-Sanchez, M., Taras, A., Coudray, C., & Polito, A. (2005). Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study. European Journal of Clinical Nutrition, 59 Suppl 2, S53-7.
Meunier N, et al. Basal Metabolic Rate and Thyroid Hormones of Late-middle-aged and Older Human Subjects: the ZENITH Study. Eur J Clin Nutr. 2005;59 Suppl 2:S53-7. PubMed PMID: 16254583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study. AU - Meunier,N, AU - Beattie,J H, AU - Ciarapica,D, AU - O'Connor,J M, AU - Andriollo-Sanchez,M, AU - Taras,A, AU - Coudray,C, AU - Polito,A, PY - 2005/10/29/pubmed PY - 2006/3/4/medline PY - 2005/10/29/entrez SP - S53 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 Suppl 2 N2 - OBJECTIVE: This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status. DESIGN: A multicentre prospective intervention study employing a randomised double blind design. SETTING: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). INTERVENTIONS: BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in Clermont-Ferrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n = 387). BMR was measured by indirect calorimetry. Fat-free mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point. RESULTS: Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (-7% P < 0.01). A negative correlation between BMR and age (men, r = -0.64; women, r = -0.62; both P < 0.0001) was observed: BMR was significantly (P < 0.000001) lower in Italian elderly volunteers (4.03+/-0.46 kJ/min and 3.29+/-0.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.84+/-0.45 kJ/min and 3.87+/-0.38 kJ/min for men and women, respectively), even after adjustment for FFM (-12%). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (TT4) concentrations were lowest in middle-aged population (-10%, P < 0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r = -0.12, P < 0.02, slope -0.026). CONCLUSIONS: The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16254583/Basal_metabolic_rate_and_thyroid_hormones_of_late_middle_aged_and_older_human_subjects:_the_ZENITH_study_ DB - PRIME DP - Unbound Medicine ER -