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Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study.
Eur J Clin Nutr. 2005 Nov; 59 Suppl 2:S58-62.EJ

Abstract

OBJECTIVE

Oxidative stress has been reported to increase with ageing. However, the data in healthy humans remain controversial and studies in free-living elderly people are scarce. The objective of the present study was to compare age-related oxidative stress in late middle-aged and older free-living subjects.

DESIGN

The effect of ageing on oxidative stress and antioxidant parameters was investigated in 188 middle-aged subjects from Clermont-Ferrand (France) and Coleraine (UK), and in 199 older subjects from Grenoble (France) and Roma (Italy). Plasma thiol (SH) groups, define definition (TBAR's) and total glutathione (GSH), define definition (FRAP), and superoxide dismutase (SOD) activity were measured at baseline of the ZENITH study.

RESULTS

Plasma SH groups and FRAP and, surprisingly, TBAR's were significantly lower in free-living older subjects compared to younger subjects (P < 0.001, P < 0.001, P < 0.01, respectively), but there was no significant differences in GSH levels.

CONCLUSION

European free-living healthy older do not appear to be exposed to an acute oxidative stress. However, the highly significant positive correlation between plasma SH group oxidation or decreased FRAP and ageing is predictive of an increased risk of oxidative stress in older subjects. Moreover, the comparison between middle-aged and older subjects regarding oxidative stress parameters suggests also a progressive and slow decline of antioxidant status in healthy free-living older elderly and underline the impact on life-style factors on successful ageing.

Authors+Show Affiliations

Andriollo-Sanchez M
Laboratoire de Nutrition Vieillissement et Maladies Cardiovasculaires, Faculté de Pharmacie, Université de Joseph Fourier, Domaine de la Merci, La Tronche, France.
Hininger-Favier I
No affiliation info available
Meunier N
No affiliation info available
Venneria E
No affiliation info available
O'Connor JM
No affiliation info available
Maiani G
No affiliation info available
Coudray C
No affiliation info available
Roussel AM
No affiliation info available

MeSH

Age FactorsAgedAgingAnalysis of VarianceAntioxidantsBiomarkersEuropeFemaleGlutathioneHumansLipid PeroxidationMaleMiddle AgedOxidative StressReference ValuesSex FactorsSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesZinc

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16254584

Citation

Andriollo-Sanchez, M, et al. "Age-related Oxidative Stress and Antioxidant Parameters in Middle-aged and Older European Subjects: the ZENITH Study." European Journal of Clinical Nutrition, vol. 59 Suppl 2, 2005, pp. S58-62.
Andriollo-Sanchez M, Hininger-Favier I, Meunier N, et al. Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study. Eur J Clin Nutr. 2005;59 Suppl 2:S58-62.
Andriollo-Sanchez, M., Hininger-Favier, I., Meunier, N., Venneria, E., O'Connor, J. M., Maiani, G., Coudray, C., & Roussel, A. M. (2005). Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study. European Journal of Clinical Nutrition, 59 Suppl 2, S58-62.
Andriollo-Sanchez M, et al. Age-related Oxidative Stress and Antioxidant Parameters in Middle-aged and Older European Subjects: the ZENITH Study. Eur J Clin Nutr. 2005;59 Suppl 2:S58-62. PubMed PMID: 16254584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study. AU - Andriollo-Sanchez,M, AU - Hininger-Favier,I, AU - Meunier,N, AU - Venneria,E, AU - O'Connor,J M, AU - Maiani,G, AU - Coudray,C, AU - Roussel,A M, PY - 2005/10/29/pubmed PY - 2006/3/4/medline PY - 2005/10/29/entrez SP - S58 EP - 62 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 Suppl 2 N2 - OBJECTIVE: Oxidative stress has been reported to increase with ageing. However, the data in healthy humans remain controversial and studies in free-living elderly people are scarce. The objective of the present study was to compare age-related oxidative stress in late middle-aged and older free-living subjects. DESIGN: The effect of ageing on oxidative stress and antioxidant parameters was investigated in 188 middle-aged subjects from Clermont-Ferrand (France) and Coleraine (UK), and in 199 older subjects from Grenoble (France) and Roma (Italy). Plasma thiol (SH) groups, define definition (TBAR's) and total glutathione (GSH), define definition (FRAP), and superoxide dismutase (SOD) activity were measured at baseline of the ZENITH study. RESULTS: Plasma SH groups and FRAP and, surprisingly, TBAR's were significantly lower in free-living older subjects compared to younger subjects (P < 0.001, P < 0.001, P < 0.01, respectively), but there was no significant differences in GSH levels. CONCLUSION: European free-living healthy older do not appear to be exposed to an acute oxidative stress. However, the highly significant positive correlation between plasma SH group oxidation or decreased FRAP and ageing is predictive of an increased risk of oxidative stress in older subjects. Moreover, the comparison between middle-aged and older subjects regarding oxidative stress parameters suggests also a progressive and slow decline of antioxidant status in healthy free-living older elderly and underline the impact on life-style factors on successful ageing. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16254584/Age_related_oxidative_stress_and_antioxidant_parameters_in_middle_aged_and_older_European_subjects:_the_ZENITH_study_ DB - PRIME DP - Unbound Medicine ER -