Tags

Type your tag names separated by a space and hit enter

Crocetin prevents dexamethasone-induced insulin resistance in rats.
Planta Med 2005; 71(10):917-22PM

Abstract

The main objective of the study was to examine whether crocetin, a natural product from Gardenia jaminoides Ellis, has beneficial effects on the state of insulin resistance induced by dexamethasone in a rat model. Measured using the oral glucose tolerance tests (OGTT), male Wistar rats treated with subcutaneous dexamethasone (0.08 mg/kg/d) for 6 weeks exhibited reduced insulin sensitivity at weeks 2 and 4 and impaired glucose tolerance at week 4. In the dexamethasone-treated group, serum insulin, free fatty acids (FFA), triglyceride (TG) and tumor necrosis factor (TNF)-alpha levels were significantly increased at the end of the study. In addition, the hepatic glycogen content was reduced as indicated by periodic acid-Schiff (PAS) staining, and pancreatic islet beta cells showed compensatory hyperactivity suggested by immunohistochemical (IHC) staining using an antibody against insulin. Treatment with crocetin (40 mg/kg/d) significantly attenuated all the described effects of dexamethasone. These results suggest that crocetin might prevent the development of dexamethasone-induced insulin resistance and related abnormalities in rats.

Authors+Show Affiliations

Department of Pharmacology, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16254822

Citation

Xi, Liang, et al. "Crocetin Prevents Dexamethasone-induced Insulin Resistance in Rats." Planta Medica, vol. 71, no. 10, 2005, pp. 917-22.
Xi L, Qian Z, Shen X, et al. Crocetin prevents dexamethasone-induced insulin resistance in rats. Planta Med. 2005;71(10):917-22.
Xi, L., Qian, Z., Shen, X., Wen, N., & Zhang, Y. (2005). Crocetin prevents dexamethasone-induced insulin resistance in rats. Planta Medica, 71(10), pp. 917-22.
Xi L, et al. Crocetin Prevents Dexamethasone-induced Insulin Resistance in Rats. Planta Med. 2005;71(10):917-22. PubMed PMID: 16254822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Crocetin prevents dexamethasone-induced insulin resistance in rats. AU - Xi,Liang, AU - Qian,Zhiyu, AU - Shen,Xiangchun, AU - Wen,Na, AU - Zhang,Yabing, PY - 2005/10/29/pubmed PY - 2005/12/20/medline PY - 2005/10/29/entrez SP - 917 EP - 22 JF - Planta medica JO - Planta Med. VL - 71 IS - 10 N2 - The main objective of the study was to examine whether crocetin, a natural product from Gardenia jaminoides Ellis, has beneficial effects on the state of insulin resistance induced by dexamethasone in a rat model. Measured using the oral glucose tolerance tests (OGTT), male Wistar rats treated with subcutaneous dexamethasone (0.08 mg/kg/d) for 6 weeks exhibited reduced insulin sensitivity at weeks 2 and 4 and impaired glucose tolerance at week 4. In the dexamethasone-treated group, serum insulin, free fatty acids (FFA), triglyceride (TG) and tumor necrosis factor (TNF)-alpha levels were significantly increased at the end of the study. In addition, the hepatic glycogen content was reduced as indicated by periodic acid-Schiff (PAS) staining, and pancreatic islet beta cells showed compensatory hyperactivity suggested by immunohistochemical (IHC) staining using an antibody against insulin. Treatment with crocetin (40 mg/kg/d) significantly attenuated all the described effects of dexamethasone. These results suggest that crocetin might prevent the development of dexamethasone-induced insulin resistance and related abnormalities in rats. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/16254822/Crocetin_prevents_dexamethasone_induced_insulin_resistance_in_rats_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2005-871248 DB - PRIME DP - Unbound Medicine ER -