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Clinical status of agents being developed for leishmaniasis.
Expert Opin Investig Drugs. 2005 Nov; 14(11):1337-46.EO

Abstract

Leishmaniasis, which exists in both visceral and cutaneous forms, is currently treated with intramuscular antimony or intravenous amphotericin B. The primary unmet need is for oral therapy. Of the several drugs in clinical development, miltefosine is unique in being an oral agent with efficacy against both forms of the disease. Sitamaquine is an oral agent with substantial but not sufficient efficacy against visceral disease. Oral fluconazole has been shown to be more effective than placebo in one instance: for Leishmania major cutaneous disease from Saudi Arabia. Paromomycin is in widespread trial. Topical paromomycin formulations are being tested for cutaneous disease, and intramuscular paromomycin is in Phase III trial for Indian visceral disease. The most likely replacements for present therapy are oral miltefosine for many of the visceral and cutaneous syndromes, intramuscular paromomycin for visceral disease and topical paromomycin for some forms of cutaneous disease.

Authors+Show Affiliations

National Center for Complementary and Alternative Medicine, 6707 Democracy Boulevard, Bethesda, MD 20892, USA. bermanjo@mail.nih.gov

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16255674

Citation

Berman, Jonathan. "Clinical Status of Agents Being Developed for Leishmaniasis." Expert Opinion On Investigational Drugs, vol. 14, no. 11, 2005, pp. 1337-46.
Berman J. Clinical status of agents being developed for leishmaniasis. Expert Opin Investig Drugs. 2005;14(11):1337-46.
Berman, J. (2005). Clinical status of agents being developed for leishmaniasis. Expert Opinion On Investigational Drugs, 14(11), 1337-46.
Berman J. Clinical Status of Agents Being Developed for Leishmaniasis. Expert Opin Investig Drugs. 2005;14(11):1337-46. PubMed PMID: 16255674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical status of agents being developed for leishmaniasis. A1 - Berman,Jonathan, PY - 2005/11/1/pubmed PY - 2006/4/1/medline PY - 2005/11/1/entrez SP - 1337 EP - 46 JF - Expert opinion on investigational drugs JO - Expert Opin Investig Drugs VL - 14 IS - 11 N2 - Leishmaniasis, which exists in both visceral and cutaneous forms, is currently treated with intramuscular antimony or intravenous amphotericin B. The primary unmet need is for oral therapy. Of the several drugs in clinical development, miltefosine is unique in being an oral agent with efficacy against both forms of the disease. Sitamaquine is an oral agent with substantial but not sufficient efficacy against visceral disease. Oral fluconazole has been shown to be more effective than placebo in one instance: for Leishmania major cutaneous disease from Saudi Arabia. Paromomycin is in widespread trial. Topical paromomycin formulations are being tested for cutaneous disease, and intramuscular paromomycin is in Phase III trial for Indian visceral disease. The most likely replacements for present therapy are oral miltefosine for many of the visceral and cutaneous syndromes, intramuscular paromomycin for visceral disease and topical paromomycin for some forms of cutaneous disease. SN - 1744-7658 UR - https://www.unboundmedicine.com/medline/citation/16255674/Clinical_status_of_agents_being_developed_for_leishmaniasis_ L2 - https://www.tandfonline.com/doi/full/10.1517/13543784.14.11.1337 DB - PRIME DP - Unbound Medicine ER -