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[Clinicopathological study of Ewing's sarcoma/primitive neuroectodermal tumor in oral and maxillofacial region].
Zhonghua Kou Qiang Yi Xue Za Zhi. 2005 Sep; 40(5):379-82.ZK

Abstract

OBJECTIVE

To study the clinicopathological features and diagnostic criteria of Ewing's sarcoma/primitive neuroectodermal tumor (Ewing's sarcoma/PNET) in oral and maxillofacial region.

METHODS

There were 15 patients with Ewing's sarcoma/PNET in the last 35 years at our hospital, aged 1-49 years and mean 14.5 years. The most common manifestation was swelling of the affected region. The cases were analyzed and histological and immunohistochemical studies were also conducted to examine CD99 (12E7), Vimentin, NSE, S-100, Syn, CD45 (LCA), desmin.

RESULTS

(1) The most common histological pattern of Ewing's sarcoma/PNET was a lobular arrangement of uniform, small, hyperchromatic cells in a fibrous background. Some of these tumors were rich in cytoplasmic glycogen. (2) Of the 7 cases, IHC was positive for CD99 (12E7) and Vimentin and negative for lymphoid (CD45), muscle (desmin) markers. S-100 was positive in 4 cases and NSE negative in 3, Syn positive in 1. NSE, S-100, Syn were all negative in 2 cases.

CONCLUSIONS

Ewing's sarcoma/PNET is more common in teenagers and young people. Immunohistochemistry is essential to distinguish Ewing's sarcoma/PNET from other small round cell tumors. Immunohistochemistry is useful in the diagnosis.

Authors+Show Affiliations

Department of Pathology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16255919

Citation

He, Hua-wei, et al. "[Clinicopathological Study of Ewing's Sarcoma/primitive Neuroectodermal Tumor in Oral and Maxillofacial Region]." Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology, vol. 40, no. 5, 2005, pp. 379-82.
He HW, Liu LK, Li YN, et al. [Clinicopathological study of Ewing's sarcoma/primitive neuroectodermal tumor in oral and maxillofacial region]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2005;40(5):379-82.
He, H. W., Liu, L. K., Li, Y. N., Wang, D., & He, Z. X. (2005). [Clinicopathological study of Ewing's sarcoma/primitive neuroectodermal tumor in oral and maxillofacial region]. Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology, 40(5), 379-82.
He HW, et al. [Clinicopathological Study of Ewing's Sarcoma/primitive Neuroectodermal Tumor in Oral and Maxillofacial Region]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2005;40(5):379-82. PubMed PMID: 16255919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinicopathological study of Ewing's sarcoma/primitive neuroectodermal tumor in oral and maxillofacial region]. AU - He,Hua-wei, AU - Liu,Lai-kui, AU - Li,Yi-ning, AU - Wang,Dan, AU - He,Zhi-xiu, PY - 2005/11/1/pubmed PY - 2009/10/30/medline PY - 2005/11/1/entrez SP - 379 EP - 82 JF - Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology JO - Zhonghua Kou Qiang Yi Xue Za Zhi VL - 40 IS - 5 N2 - OBJECTIVE: To study the clinicopathological features and diagnostic criteria of Ewing's sarcoma/primitive neuroectodermal tumor (Ewing's sarcoma/PNET) in oral and maxillofacial region. METHODS: There were 15 patients with Ewing's sarcoma/PNET in the last 35 years at our hospital, aged 1-49 years and mean 14.5 years. The most common manifestation was swelling of the affected region. The cases were analyzed and histological and immunohistochemical studies were also conducted to examine CD99 (12E7), Vimentin, NSE, S-100, Syn, CD45 (LCA), desmin. RESULTS: (1) The most common histological pattern of Ewing's sarcoma/PNET was a lobular arrangement of uniform, small, hyperchromatic cells in a fibrous background. Some of these tumors were rich in cytoplasmic glycogen. (2) Of the 7 cases, IHC was positive for CD99 (12E7) and Vimentin and negative for lymphoid (CD45), muscle (desmin) markers. S-100 was positive in 4 cases and NSE negative in 3, Syn positive in 1. NSE, S-100, Syn were all negative in 2 cases. CONCLUSIONS: Ewing's sarcoma/PNET is more common in teenagers and young people. Immunohistochemistry is essential to distinguish Ewing's sarcoma/PNET from other small round cell tumors. Immunohistochemistry is useful in the diagnosis. SN - 1002-0098 UR - https://www.unboundmedicine.com/medline/citation/16255919/[Clinicopathological_study_of_Ewing's_sarcoma/primitive_neuroectodermal_tumor_in_oral_and_maxillofacial_region]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=1002-0098&year=2005&vol=40&issue=5&fpage=379 DB - PRIME DP - Unbound Medicine ER -