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Feline immunodeficiency virus vaccine: implications for diagnostic testing and disease management.
Biologicals. 2005 Dec; 33(4):215-7.B

Abstract

Feline immunodeficiency virus (FIV) is a common feline pathogen, with an overall infection prevalence of approximately 11% in cats worldwide. Most infected cats eventually succumb due to direct viral effects or, more commonly, to secondary infections resulting from virus-induced immunosuppression. FIV infection is considered lifelong, and diagnosis most often relies on detection of virus-specific antibodies. A currently available whole virus, adjuvanted, inactivated FIV vaccine induces antibodies in vaccinates that is indistinguishable from those induced by infection. As a result, currently available diagnostic tests cannot reliably distinguish vaccinated cats from infected cats, or from cats that are both vaccinated and infected. From both an epidemiologic and an individual cat perspective, it is impossible to determine whether use of this vaccination is more beneficial than it is harmful.

Authors+Show Affiliations

Richards JR
Cornell Feline Health Center, Cornell University College of Veterinary Medicine, S3 111 Schurman Hall, Ithaca, NY 14853, USA. jrr1@cornell.edu

MeSH

AnimalsAntibodies, ViralCat DiseasesCatsDiagnostic ErrorsImmunodeficiency Virus, FelineLentivirus InfectionsViral Vaccines

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

16257536

Citation

Richards, James R.. "Feline Immunodeficiency Virus Vaccine: Implications for Diagnostic Testing and Disease Management." Biologicals : Journal of the International Association of Biological Standardization, vol. 33, no. 4, 2005, pp. 215-7.
Richards JR. Feline immunodeficiency virus vaccine: implications for diagnostic testing and disease management. Biologicals. 2005;33(4):215-7.
Richards, J. R. (2005). Feline immunodeficiency virus vaccine: implications for diagnostic testing and disease management. Biologicals : Journal of the International Association of Biological Standardization, 33(4), 215-7.
Richards JR. Feline Immunodeficiency Virus Vaccine: Implications for Diagnostic Testing and Disease Management. Biologicals. 2005;33(4):215-7. PubMed PMID: 16257536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Feline immunodeficiency virus vaccine: implications for diagnostic testing and disease management. A1 - Richards,James R, Y1 - 2005/10/28/ PY - 2005/08/18/accepted PY - 2005/11/1/pubmed PY - 2006/3/1/medline PY - 2005/11/1/entrez SP - 215 EP - 7 JF - Biologicals : journal of the International Association of Biological Standardization JO - Biologicals VL - 33 IS - 4 N2 - Feline immunodeficiency virus (FIV) is a common feline pathogen, with an overall infection prevalence of approximately 11% in cats worldwide. Most infected cats eventually succumb due to direct viral effects or, more commonly, to secondary infections resulting from virus-induced immunosuppression. FIV infection is considered lifelong, and diagnosis most often relies on detection of virus-specific antibodies. A currently available whole virus, adjuvanted, inactivated FIV vaccine induces antibodies in vaccinates that is indistinguishable from those induced by infection. As a result, currently available diagnostic tests cannot reliably distinguish vaccinated cats from infected cats, or from cats that are both vaccinated and infected. From both an epidemiologic and an individual cat perspective, it is impossible to determine whether use of this vaccination is more beneficial than it is harmful. SN - 1045-1056 UR - https://www.unboundmedicine.com/medline/citation/16257536/Feline_immunodeficiency_virus_vaccine:_implications_for_diagnostic_testing_and_disease_management_ DB - PRIME DP - Unbound Medicine ER -