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Effect of dietary lipids on plasma fatty acid profiles and prostaglandin and leptin production in gilthead seabream (Sparus aurata).
Comp Biochem Physiol B Biochem Mol Biol. 2005 Dec; 142(4):410-8.CB

Abstract

The aim of this study was to investigate the effects of different levels of substitution of fish oil by vegetable oils rich in oleic, linoleic and linolenic acids on gilthead seabream plasma and leukocyte fatty acid compositions and prostaglandin (PG) and leptin production. Juvenile seabream of 24 g initial body mass were fed four iso-energetic and iso-proteic experimental diets for 281 days. Fatty acid composition of plasma lipids was markedly affected by the inclusion of vegetable oils (VO). ARA (arachidonate), EPA (eicosapentaenoate) and DHA (docosahexaenoate) were preferentially incorporated into polar lipids of plasma, and DHGLA (di-homogammalinoleate) accumulated with increased vegetable oil inclusion. Dietary treatments resulted in alterations of DHGLA/ARA ratios, but not ARA/EPA. ARA-derived PGE(2) production in plasma was not affected by vegetable oils, in agreement with similar eicosanoid precursor ratio (ARA/EPA) in leukocytes total lipids and plasma phospholipids among fish fed with the different dietary treatments. Feeding vegetable oils leads to a decrease in plasma EPA which in turn reduced plasma PGE(3) concentration. Moreover, PGE(3) was the major prostaglandin produced in plasma of fish fed fish oil based diet. Such findings point out the importance of EPA as a precursor of prostaglandins in marine fish, at least for the correct function of the blood cells, and correlates well with the predominant role of this fatty acid in immune regulation in this species. A negative correlation was found between plasma PGE(2) and leptin plasma concentration, suggesting that circulating levels of leptin may act as a metabolic signal modulating PGE(2) release. The present study has shown that increased inclusion of vegetable oils in diet for gilthead seabream may profoundly affect the fatty acid composition of plasma and leukocytes, specially HUFA (highly unsaturated fatty acids), and consequently the production of PGE(3), which can be a major PG in plasma. Alteration in the amount and type of PG produced can be at least partially responsible for the changes in the immune system and health parameters of fish fed diets with high inclusion of VO.

Authors+Show Affiliations

Grupo de Investigación en Acuicultura. ULPGC & ICCM. P.O. Box 56, 35200, Telde, Las Palmas, Canary Islands, Spain. rgaqua2003@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16257554

Citation

Ganga, R, et al. "Effect of Dietary Lipids On Plasma Fatty Acid Profiles and Prostaglandin and Leptin Production in Gilthead Seabream (Sparus Aurata)." Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, vol. 142, no. 4, 2005, pp. 410-8.
Ganga R, Bell JG, Montero D, et al. Effect of dietary lipids on plasma fatty acid profiles and prostaglandin and leptin production in gilthead seabream (Sparus aurata). Comp Biochem Physiol B Biochem Mol Biol. 2005;142(4):410-8.
Ganga, R., Bell, J. G., Montero, D., Robaina, L., Caballero, M. J., & Izquierdo, M. S. (2005). Effect of dietary lipids on plasma fatty acid profiles and prostaglandin and leptin production in gilthead seabream (Sparus aurata). Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 142(4), 410-8.
Ganga R, et al. Effect of Dietary Lipids On Plasma Fatty Acid Profiles and Prostaglandin and Leptin Production in Gilthead Seabream (Sparus Aurata). Comp Biochem Physiol B Biochem Mol Biol. 2005;142(4):410-8. PubMed PMID: 16257554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary lipids on plasma fatty acid profiles and prostaglandin and leptin production in gilthead seabream (Sparus aurata). AU - Ganga,R, AU - Bell,J G, AU - Montero,D, AU - Robaina,L, AU - Caballero,M J, AU - Izquierdo,M S, Y1 - 2005/10/28/ PY - 2005/04/07/received PY - 2005/09/09/revised PY - 2005/09/10/accepted PY - 2005/11/1/pubmed PY - 2006/3/10/medline PY - 2005/11/1/entrez SP - 410 EP - 8 JF - Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology JO - Comp Biochem Physiol B Biochem Mol Biol VL - 142 IS - 4 N2 - The aim of this study was to investigate the effects of different levels of substitution of fish oil by vegetable oils rich in oleic, linoleic and linolenic acids on gilthead seabream plasma and leukocyte fatty acid compositions and prostaglandin (PG) and leptin production. Juvenile seabream of 24 g initial body mass were fed four iso-energetic and iso-proteic experimental diets for 281 days. Fatty acid composition of plasma lipids was markedly affected by the inclusion of vegetable oils (VO). ARA (arachidonate), EPA (eicosapentaenoate) and DHA (docosahexaenoate) were preferentially incorporated into polar lipids of plasma, and DHGLA (di-homogammalinoleate) accumulated with increased vegetable oil inclusion. Dietary treatments resulted in alterations of DHGLA/ARA ratios, but not ARA/EPA. ARA-derived PGE(2) production in plasma was not affected by vegetable oils, in agreement with similar eicosanoid precursor ratio (ARA/EPA) in leukocytes total lipids and plasma phospholipids among fish fed with the different dietary treatments. Feeding vegetable oils leads to a decrease in plasma EPA which in turn reduced plasma PGE(3) concentration. Moreover, PGE(3) was the major prostaglandin produced in plasma of fish fed fish oil based diet. Such findings point out the importance of EPA as a precursor of prostaglandins in marine fish, at least for the correct function of the blood cells, and correlates well with the predominant role of this fatty acid in immune regulation in this species. A negative correlation was found between plasma PGE(2) and leptin plasma concentration, suggesting that circulating levels of leptin may act as a metabolic signal modulating PGE(2) release. The present study has shown that increased inclusion of vegetable oils in diet for gilthead seabream may profoundly affect the fatty acid composition of plasma and leukocytes, specially HUFA (highly unsaturated fatty acids), and consequently the production of PGE(3), which can be a major PG in plasma. Alteration in the amount and type of PG produced can be at least partially responsible for the changes in the immune system and health parameters of fish fed diets with high inclusion of VO. SN - 1096-4959 UR - https://www.unboundmedicine.com/medline/citation/16257554/Effect_of_dietary_lipids_on_plasma_fatty_acid_profiles_and_prostaglandin_and_leptin_production_in_gilthead_seabream__Sparus_aurata__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096-4959(05)00209-5 DB - PRIME DP - Unbound Medicine ER -