Tags

Type your tag names separated by a space and hit enter

Weight history and risk of endometrial cancer among Chinese women.

Abstract

BACKGROUND

Adult obesity is a well-established risk factor for endometrial cancer. However, little is known about the association of endometrial cancer risk with body size early in life and weight change during adulthood. We investigated whether women with greater early-age body size or with greater weight change during adulthood have an increased risk of endometrial cancer.

METHODS

We analysed data from a population-based case-control study of endometrial cancer conducted between 1997 and 2001 in Shanghai, China. Included in this analysis were 832 endometrial cancer cases aged 30-69 years and 846 population controls. Information on weight and height history from adolescence through adulthood was obtained via structured in-person interviews. A logistic regression model was used to derive odds ratios (ORs) and 95% confidence intervals (CIs) for endometrial cancer in association with adolescent and adult adiposity, as well as adult body weight change. All ORs were adjusted for age, education, menstrual status, duration of menstruation, number of pregnancies, oral contraceptive use, and family history of cancer.

RESULTS

Perceived weights and heights during puberty that were greater than average were associated with a modestly increased risk of cancer. The association for perceived weight was substantially weakened after adjustment for current body mass index (BMI). High BMI at all adult ages significantly predicted endometrial cancer risk, with recent BMI being the strongest predictor. Further analyses disclosed that weight gain during adulthood, particularly during the peri-menopausal period (age 40-50 years), was associated with a significantly elevated risk of endometrial cancer, even among currently non-obese women. Gaining >5 kg between age 40 and 50 was related to ORs of 2.3 (95% CI 1.4-3.9) for women with a BMI<25 kg/m2 and 2.0 (95% CI 1.3-3.0) for women with BMI>or=25 kg/m2.

CONCLUSIONS

Adult weight gain, particularly during the peri-menopausal period, plays a significant role in the development of endometrial cancer risk.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Shanghai Cancer Institute, Cancer Institute of Shanghai Jiaotong University, 2200/25 Xie Tu Road, Shanghai 200032, P.R. China.

    , , , , , ,

    Source

    MeSH

    Body Height
    Body Mass Index
    Case-Control Studies
    China
    Endometrial Neoplasms
    Female
    Humans
    Logistic Models
    Middle Aged
    Postmenopause
    Risk Assessment
    Weight Gain

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    16258056

    Citation

    Xu, Wang Hong, et al. "Weight History and Risk of Endometrial Cancer Among Chinese Women." International Journal of Epidemiology, vol. 35, no. 1, 2006, pp. 159-66.
    Xu WH, Xiang YB, Zheng W, et al. Weight history and risk of endometrial cancer among Chinese women. Int J Epidemiol. 2006;35(1):159-66.
    Xu, W. H., Xiang, Y. B., Zheng, W., Zhang, X., Ruan, Z. X., Cheng, J. R., ... Shu, X. O. (2006). Weight history and risk of endometrial cancer among Chinese women. International Journal of Epidemiology, 35(1), pp. 159-66.
    Xu WH, et al. Weight History and Risk of Endometrial Cancer Among Chinese Women. Int J Epidemiol. 2006;35(1):159-66. PubMed PMID: 16258056.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Weight history and risk of endometrial cancer among Chinese women. AU - Xu,Wang Hong, AU - Xiang,Yong Bing, AU - Zheng,Wei, AU - Zhang,Xianglan, AU - Ruan,Zhi Xian, AU - Cheng,Jia Rong, AU - Gao,Yu-Tang, AU - Shu,Xiao-Ou, Y1 - 2005/10/28/ PY - 2005/11/1/pubmed PY - 2006/3/10/medline PY - 2005/11/1/entrez SP - 159 EP - 66 JF - International journal of epidemiology JO - Int J Epidemiol VL - 35 IS - 1 N2 - BACKGROUND: Adult obesity is a well-established risk factor for endometrial cancer. However, little is known about the association of endometrial cancer risk with body size early in life and weight change during adulthood. We investigated whether women with greater early-age body size or with greater weight change during adulthood have an increased risk of endometrial cancer. METHODS: We analysed data from a population-based case-control study of endometrial cancer conducted between 1997 and 2001 in Shanghai, China. Included in this analysis were 832 endometrial cancer cases aged 30-69 years and 846 population controls. Information on weight and height history from adolescence through adulthood was obtained via structured in-person interviews. A logistic regression model was used to derive odds ratios (ORs) and 95% confidence intervals (CIs) for endometrial cancer in association with adolescent and adult adiposity, as well as adult body weight change. All ORs were adjusted for age, education, menstrual status, duration of menstruation, number of pregnancies, oral contraceptive use, and family history of cancer. RESULTS: Perceived weights and heights during puberty that were greater than average were associated with a modestly increased risk of cancer. The association for perceived weight was substantially weakened after adjustment for current body mass index (BMI). High BMI at all adult ages significantly predicted endometrial cancer risk, with recent BMI being the strongest predictor. Further analyses disclosed that weight gain during adulthood, particularly during the peri-menopausal period (age 40-50 years), was associated with a significantly elevated risk of endometrial cancer, even among currently non-obese women. Gaining >5 kg between age 40 and 50 was related to ORs of 2.3 (95% CI 1.4-3.9) for women with a BMI<25 kg/m2 and 2.0 (95% CI 1.3-3.0) for women with BMI>or=25 kg/m2. CONCLUSIONS: Adult weight gain, particularly during the peri-menopausal period, plays a significant role in the development of endometrial cancer risk. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/16258056/Weight_history_and_risk_of_endometrial_cancer_among_Chinese_women_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyi223 DB - PRIME DP - Unbound Medicine ER -