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Effects of granisetron with droperidol or dexamethasone on prevention of postoperative nausea and vomiting after general anesthesia for cesarean section.
Methods Find Exp Clin Pharmacol. 2005 Sep; 27(7):489-93.MF

Abstract

This prospective, placebo-controlled, double-blinded, and randomized study was undertaken to compare the efficacy of granisetron, droperidol, and combinations of granisetron with droperidol or dexamethasone on postoperative nausea and vomiting in patients undergoing general anesthesia for cesarean section. Patients (n = 150) who were scheduled for cesarean section under general anesthesia were randomly assigned to one of the five groups: physiological saline 5 ml in Group A, granisetron 40 microg/kg + dexamethasone 8 mg in Group B, granisetron 40 microg/kg + droperidol 1.25 mg in Group C, droperidol 1.25 mg in Group D, and granisetron 40 microg/kg in Group E were administered intravenously after clamping of the fetal umbilical cord. Postoperative nausea and vomiting was observed for 024 h after the anesthesia. Cesarean sections were all performed under general anesthesia. Postoperative nausea and vomiting was more common in placebo group (56.7%) than the others during the 0-24 h after the anesthesia (p < 0.05). All granisetron groups were more effective than placebo and droperidol groups during the postoperative 3-24 h (p < 0.01). Although this trial lacks statistical power, granisetron alone and combinations with droperidol or dexamethasone were effective similarly. All treatment groups, except droperidol during the postoperative 3-24 h, were effective for prevention of postoperative nausea and vomiting during the postoperative 0-24 h.

Authors+Show Affiliations

Department of Anesthesiology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey. serhatk@omu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16258594

Citation

Kocamanoglu, I S., et al. "Effects of Granisetron With Droperidol or Dexamethasone On Prevention of Postoperative Nausea and Vomiting After General Anesthesia for Cesarean Section." Methods and Findings in Experimental and Clinical Pharmacology, vol. 27, no. 7, 2005, pp. 489-93.
Kocamanoglu IS, Baris S, Karakaya D, et al. Effects of granisetron with droperidol or dexamethasone on prevention of postoperative nausea and vomiting after general anesthesia for cesarean section. Methods Find Exp Clin Pharmacol. 2005;27(7):489-93.
Kocamanoglu, I. S., Baris, S., Karakaya, D., Sener, B., Tur, A., & Cetinkaya, M. (2005). Effects of granisetron with droperidol or dexamethasone on prevention of postoperative nausea and vomiting after general anesthesia for cesarean section. Methods and Findings in Experimental and Clinical Pharmacology, 27(7), 489-93.
Kocamanoglu IS, et al. Effects of Granisetron With Droperidol or Dexamethasone On Prevention of Postoperative Nausea and Vomiting After General Anesthesia for Cesarean Section. Methods Find Exp Clin Pharmacol. 2005;27(7):489-93. PubMed PMID: 16258594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of granisetron with droperidol or dexamethasone on prevention of postoperative nausea and vomiting after general anesthesia for cesarean section. AU - Kocamanoglu,I S, AU - Baris,S, AU - Karakaya,D, AU - Sener,B, AU - Tur,A, AU - Cetinkaya,M, PY - 2005/11/1/pubmed PY - 2006/1/21/medline PY - 2005/11/1/entrez SP - 489 EP - 93 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 27 IS - 7 N2 - This prospective, placebo-controlled, double-blinded, and randomized study was undertaken to compare the efficacy of granisetron, droperidol, and combinations of granisetron with droperidol or dexamethasone on postoperative nausea and vomiting in patients undergoing general anesthesia for cesarean section. Patients (n = 150) who were scheduled for cesarean section under general anesthesia were randomly assigned to one of the five groups: physiological saline 5 ml in Group A, granisetron 40 microg/kg + dexamethasone 8 mg in Group B, granisetron 40 microg/kg + droperidol 1.25 mg in Group C, droperidol 1.25 mg in Group D, and granisetron 40 microg/kg in Group E were administered intravenously after clamping of the fetal umbilical cord. Postoperative nausea and vomiting was observed for 024 h after the anesthesia. Cesarean sections were all performed under general anesthesia. Postoperative nausea and vomiting was more common in placebo group (56.7%) than the others during the 0-24 h after the anesthesia (p < 0.05). All granisetron groups were more effective than placebo and droperidol groups during the postoperative 3-24 h (p < 0.01). Although this trial lacks statistical power, granisetron alone and combinations with droperidol or dexamethasone were effective similarly. All treatment groups, except droperidol during the postoperative 3-24 h, were effective for prevention of postoperative nausea and vomiting during the postoperative 0-24 h. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/16258594/Effects_of_granisetron_with_droperidol_or_dexamethasone_on_prevention_of_postoperative_nausea_and_vomiting_after_general_anesthesia_for_cesarean_section_ L2 - http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=6&amp;p_RefId=920930 DB - PRIME DP - Unbound Medicine ER -