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Electrochemical study of natamycin--analytical application to pharmaceutical dosage forms by differential pulse voltammetry.
Pharmazie. 2005 Oct; 60(10):747-50.P

Abstract

The electrochemical oxidation and determination of natamycin has been carried out at a carbon paste electrode in aqueous solutions in the pH range of 2.5-10.30 by cyclic and differential pulse voltammetry. Best results were obtained with the differential pulse voltammetric technique in 0.5 M sulfuric acid at pH 1.82. The diffusion controlled nature of the waves was established. A differential pulse voltammetric technique for the determination of natamycin 0.5 M sulfuric acid which allows quantitation over the range of 2 x 10(-6)-8 x 10(-5) M range method is proposed. Limit of detection and limit of quantitatification were 1.5 x 10(-6) and 5 x 10(-6) M, respectively. Based on this study a simple, rapid, selective and sensitive voltammetric method was developed for the determination of natamycin in capsules. In order to validate the proposed method, UV spectroscopy was applied.

Authors+Show Affiliations

Department of Molecular Biology, Faculty of Arts and Sciences, University of Canakkale Onsekiz Mart, Canakkale, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16259121

Citation

Aki, C, et al. "Electrochemical Study of Natamycin--analytical Application to Pharmaceutical Dosage Forms By Differential Pulse Voltammetry." Die Pharmazie, vol. 60, no. 10, 2005, pp. 747-50.
Aki C, Yilmaz S, Dilgin Y, et al. Electrochemical study of natamycin--analytical application to pharmaceutical dosage forms by differential pulse voltammetry. Pharmazie. 2005;60(10):747-50.
Aki, C., Yilmaz, S., Dilgin, Y., Yagmur, S., & Suren, E. (2005). Electrochemical study of natamycin--analytical application to pharmaceutical dosage forms by differential pulse voltammetry. Die Pharmazie, 60(10), 747-50.
Aki C, et al. Electrochemical Study of Natamycin--analytical Application to Pharmaceutical Dosage Forms By Differential Pulse Voltammetry. Pharmazie. 2005;60(10):747-50. PubMed PMID: 16259121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemical study of natamycin--analytical application to pharmaceutical dosage forms by differential pulse voltammetry. AU - Aki,C, AU - Yilmaz,S, AU - Dilgin,Y, AU - Yagmur,S, AU - Suren,E, PY - 2005/11/2/pubmed PY - 2005/12/13/medline PY - 2005/11/2/entrez SP - 747 EP - 50 JF - Die Pharmazie JO - Pharmazie VL - 60 IS - 10 N2 - The electrochemical oxidation and determination of natamycin has been carried out at a carbon paste electrode in aqueous solutions in the pH range of 2.5-10.30 by cyclic and differential pulse voltammetry. Best results were obtained with the differential pulse voltammetric technique in 0.5 M sulfuric acid at pH 1.82. The diffusion controlled nature of the waves was established. A differential pulse voltammetric technique for the determination of natamycin 0.5 M sulfuric acid which allows quantitation over the range of 2 x 10(-6)-8 x 10(-5) M range method is proposed. Limit of detection and limit of quantitatification were 1.5 x 10(-6) and 5 x 10(-6) M, respectively. Based on this study a simple, rapid, selective and sensitive voltammetric method was developed for the determination of natamycin in capsules. In order to validate the proposed method, UV spectroscopy was applied. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/16259121/Electrochemical_study_of_natamycin__analytical_application_to_pharmaceutical_dosage_forms_by_differential_pulse_voltammetry_ DB - PRIME DP - Unbound Medicine ER -