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Association of paternal age at birth and the risk of breast cancer in offspring: a case control study.
BMC Cancer 2005; 5:143BC

Abstract

BACKGROUND

Older paternal age may increase the germ cell mutation rate in the offspring. Maternal age may also mediate in utero exposure to pregnancy hormones in the offspring. To evaluate the association between paternal and maternal age at birth with the risk of breast cancer in female offspring, a case-control study was conducted in Korea.

METHODS

Histologically confirmed breast cancer cases (n = 1,011) and controls (n = 1,011) with no present or previous history of cancer, matched on year of birth and menopausal status, were selected from several teaching hospitals and community in Seoul during 1995-2003. Information on paternal and maternal ages and other factors was collected by interviewed questionnaire. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by unconditional logistic regression model adjusting for family history of breast cancer in 1st or 2nd degree relatives, and lifetime estrogen exposure duration.

RESULTS

The risk of breast cancer significantly increased as the paternal age increased (p for trend = 0.025). The association was stronger after controlling for maternal age; women whose fathers were aged >or=40 years at their birth had 1.6-fold increased risk of breast cancer compared with fathers aged <30 years. This association was profound in breast cancer cases in premenopausal women (OR = 1.9, 95% CI = 1.12-3.26, for paternal aged >or=40 vs. <30) (p for trend = 0.031). Although the risk of breast cancer increased as maternal age increased up to the intermediate, and then reduced; the risks in women whose mother were aged 25-29, 30-34, and >or=35 yrs at birth compared to women whose mothers were aged <25 years, were 1.2, 1.4, and 0.8, respectively, the trend was not significant (p for trend = 0.998).

CONCLUSION

These findings suggest that older paternal age increases the risk of breast cancer in their female offspring.

Authors+Show Affiliations

Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul 110-799 Korea. miso77@snu.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16259637

Citation

Choi, Ji-Yeob, et al. "Association of Paternal Age at Birth and the Risk of Breast Cancer in Offspring: a Case Control Study." BMC Cancer, vol. 5, 2005, p. 143.
Choi JY, Lee KM, Park SK, et al. Association of paternal age at birth and the risk of breast cancer in offspring: a case control study. BMC Cancer. 2005;5:143.
Choi, J. Y., Lee, K. M., Park, S. K., Noh, D. Y., Ahn, S. H., Yoo, K. Y., & Kang, D. (2005). Association of paternal age at birth and the risk of breast cancer in offspring: a case control study. BMC Cancer, 5, p. 143.
Choi JY, et al. Association of Paternal Age at Birth and the Risk of Breast Cancer in Offspring: a Case Control Study. BMC Cancer. 2005 Oct 31;5:143. PubMed PMID: 16259637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of paternal age at birth and the risk of breast cancer in offspring: a case control study. AU - Choi,Ji-Yeob, AU - Lee,Kyoung-Mu, AU - Park,Sue Kyung, AU - Noh,Dong-Young, AU - Ahn,Sei-Hyun, AU - Yoo,Keun-Young, AU - Kang,Daehee, Y1 - 2005/10/31/ PY - 2005/07/08/received PY - 2005/10/31/accepted PY - 2005/11/2/pubmed PY - 2006/2/28/medline PY - 2005/11/2/entrez SP - 143 EP - 143 JF - BMC cancer JO - BMC Cancer VL - 5 N2 - BACKGROUND: Older paternal age may increase the germ cell mutation rate in the offspring. Maternal age may also mediate in utero exposure to pregnancy hormones in the offspring. To evaluate the association between paternal and maternal age at birth with the risk of breast cancer in female offspring, a case-control study was conducted in Korea. METHODS: Histologically confirmed breast cancer cases (n = 1,011) and controls (n = 1,011) with no present or previous history of cancer, matched on year of birth and menopausal status, were selected from several teaching hospitals and community in Seoul during 1995-2003. Information on paternal and maternal ages and other factors was collected by interviewed questionnaire. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by unconditional logistic regression model adjusting for family history of breast cancer in 1st or 2nd degree relatives, and lifetime estrogen exposure duration. RESULTS: The risk of breast cancer significantly increased as the paternal age increased (p for trend = 0.025). The association was stronger after controlling for maternal age; women whose fathers were aged >or=40 years at their birth had 1.6-fold increased risk of breast cancer compared with fathers aged <30 years. This association was profound in breast cancer cases in premenopausal women (OR = 1.9, 95% CI = 1.12-3.26, for paternal aged >or=40 vs. <30) (p for trend = 0.031). Although the risk of breast cancer increased as maternal age increased up to the intermediate, and then reduced; the risks in women whose mother were aged 25-29, 30-34, and >or=35 yrs at birth compared to women whose mothers were aged <25 years, were 1.2, 1.4, and 0.8, respectively, the trend was not significant (p for trend = 0.998). CONCLUSION: These findings suggest that older paternal age increases the risk of breast cancer in their female offspring. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/16259637/Association_of_paternal_age_at_birth_and_the_risk_of_breast_cancer_in_offspring:_a_case_control_study_ L2 - https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-5-143 DB - PRIME DP - Unbound Medicine ER -