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Hydrodynamic simulation (computational fluid dynamics) of asymmetrically positioned tablets in the paddle dissolution apparatus: impact on dissolution rate and variability.
J Pharm Pharmacol. 2005 Oct; 57(10):1243-50.JP

Abstract

The aim of this work was to investigate the dissolution rate from both the curved and planar surfaces of cylindrical compacts of benzoic acid, which were placed centrally and non-centrally at the base of the vessel of the paddle dissolution apparatus. The effect of fixing the compacts to a particular position on the variability of dissolution results was also examined. In addition, computational fluid dynamics (CFD) was used to simulate fluid flow around compacts in the different positions in the vessel, and the relationship between the local hydrodynamics in the region of the compacts and the dissolution rate determined. The dissolution rate was found to increase from the centre position to the off-centre positions for each surface examined. There was a corresponding increase in maximum fluid velocities calculated from the CFD fluid flow simulations at a fixed distance from the compact. There was less variability in dissolution from compacts fixed to any of the positions compared with those that were not fixed. Fluid flow around compacts in different positions could be successfully modelled, and hydrodynamic variability examined, using CFD. The effect of asymmetric fluid flow was evident visually from the change in shape of the eroded compacts.

Authors+Show Affiliations

D'Arcy DM
School of Pharmacy, University of Dublin, Trinity College, Dublin 2, Ireland.
Corrigan OI
No affiliation info available
Healy AM
No affiliation info available

MeSH

Benzoic AcidComputer SimulationEquipment DesignRheologySolubilityTabletsTechnology, Pharmaceutical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16259752

Citation

D'Arcy, D M., et al. "Hydrodynamic Simulation (computational Fluid Dynamics) of Asymmetrically Positioned Tablets in the Paddle Dissolution Apparatus: Impact On Dissolution Rate and Variability." The Journal of Pharmacy and Pharmacology, vol. 57, no. 10, 2005, pp. 1243-50.
D'Arcy DM, Corrigan OI, Healy AM. Hydrodynamic simulation (computational fluid dynamics) of asymmetrically positioned tablets in the paddle dissolution apparatus: impact on dissolution rate and variability. J Pharm Pharmacol. 2005;57(10):1243-50.
D'Arcy, D. M., Corrigan, O. I., & Healy, A. M. (2005). Hydrodynamic simulation (computational fluid dynamics) of asymmetrically positioned tablets in the paddle dissolution apparatus: impact on dissolution rate and variability. The Journal of Pharmacy and Pharmacology, 57(10), 1243-50.
D'Arcy DM, Corrigan OI, Healy AM. Hydrodynamic Simulation (computational Fluid Dynamics) of Asymmetrically Positioned Tablets in the Paddle Dissolution Apparatus: Impact On Dissolution Rate and Variability. J Pharm Pharmacol. 2005;57(10):1243-50. PubMed PMID: 16259752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrodynamic simulation (computational fluid dynamics) of asymmetrically positioned tablets in the paddle dissolution apparatus: impact on dissolution rate and variability. AU - D'Arcy,D M, AU - Corrigan,O I, AU - Healy,A M, PY - 2005/11/2/pubmed PY - 2006/4/19/medline PY - 2005/11/2/entrez SP - 1243 EP - 50 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 57 IS - 10 N2 - The aim of this work was to investigate the dissolution rate from both the curved and planar surfaces of cylindrical compacts of benzoic acid, which were placed centrally and non-centrally at the base of the vessel of the paddle dissolution apparatus. The effect of fixing the compacts to a particular position on the variability of dissolution results was also examined. In addition, computational fluid dynamics (CFD) was used to simulate fluid flow around compacts in the different positions in the vessel, and the relationship between the local hydrodynamics in the region of the compacts and the dissolution rate determined. The dissolution rate was found to increase from the centre position to the off-centre positions for each surface examined. There was a corresponding increase in maximum fluid velocities calculated from the CFD fluid flow simulations at a fixed distance from the compact. There was less variability in dissolution from compacts fixed to any of the positions compared with those that were not fixed. Fluid flow around compacts in different positions could be successfully modelled, and hydrodynamic variability examined, using CFD. The effect of asymmetric fluid flow was evident visually from the change in shape of the eroded compacts. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/16259752/Hydrodynamic_simulation__computational_fluid_dynamics__of_asymmetrically_positioned_tablets_in_the_paddle_dissolution_apparatus:_impact_on_dissolution_rate_and_variability_ DB - PRIME DP - Unbound Medicine ER -