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Fast-melting tablets based on highly plastic granules.
J Control Release. 2005 Dec 05; 109(1-3):203-10.JC

Abstract

Highly plastic granules that can be compressed into tablets at low pressure were developed to make fast-melting tablets (FMTs) by compression method. The highly plastic granules are composed of three components: a plastic material, a material enhancing water penetration, and a wet binder. One of the unique properties of the highly plastic granules is that they maintain a porous structure even after compression into tablets. The porous and plastic nature of the granules allows fast absorption of water into the compressed tablet for fast melting/dissolution of the tablet. The prepared tablets possess tablet strength and friability that are suitable for multi-tablet packages. The three-component highly plastic granules provide an effective way of making FMTs by compression.

Authors+Show Affiliations

Fu Y
Akina Inc., West Lafayette, IN 47906, USA.
Jeong SH
No affiliation info available
Park K
No affiliation info available

MeSH

Chemistry, PharmaceuticalExcipientsHardnessMicroscopy, Electron, ScanningParticle SizePermeabilityPlasticsPowdersSolubilityTabletsWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16260059

Citation

Fu, Yourong, et al. "Fast-melting Tablets Based On Highly Plastic Granules." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 109, no. 1-3, 2005, pp. 203-10.
Fu Y, Jeong SH, Park K. Fast-melting tablets based on highly plastic granules. J Control Release. 2005;109(1-3):203-10.
Fu, Y., Jeong, S. H., & Park, K. (2005). Fast-melting tablets based on highly plastic granules. Journal of Controlled Release : Official Journal of the Controlled Release Society, 109(1-3), 203-10.
Fu Y, Jeong SH, Park K. Fast-melting Tablets Based On Highly Plastic Granules. J Control Release. 2005 Dec 5;109(1-3):203-10. PubMed PMID: 16260059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fast-melting tablets based on highly plastic granules. AU - Fu,Yourong, AU - Jeong,Seong Hoon, AU - Park,Kinam, Y1 - 2005/11/02/ PY - 2005/03/01/received PY - 2005/08/15/accepted PY - 2005/11/2/pubmed PY - 2006/3/1/medline PY - 2005/11/2/entrez SP - 203 EP - 10 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 109 IS - 1-3 N2 - Highly plastic granules that can be compressed into tablets at low pressure were developed to make fast-melting tablets (FMTs) by compression method. The highly plastic granules are composed of three components: a plastic material, a material enhancing water penetration, and a wet binder. One of the unique properties of the highly plastic granules is that they maintain a porous structure even after compression into tablets. The porous and plastic nature of the granules allows fast absorption of water into the compressed tablet for fast melting/dissolution of the tablet. The prepared tablets possess tablet strength and friability that are suitable for multi-tablet packages. The three-component highly plastic granules provide an effective way of making FMTs by compression. SN - 0168-3659 UR - https://www.unboundmedicine.com/medline/citation/16260059/Fast_melting_tablets_based_on_highly_plastic_granules_ DB - PRIME DP - Unbound Medicine ER -