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A French national survey on infiltrating breast cancer: analysis of clinico-pathological features and treatment modalities in 1159 patients.
Breast Cancer Res Treat. 2006 Jan; 95(1):55-64.BC

Abstract

BACKGROUND

Despite the approximate 42,000 yearly new cases of breast cancer in France, there have been very few exhaustive studies on the clinicopathological features and treatment options of this disease.

METHODS

Thus, a prospective, non-selective, nationwide survey on infiltrating breast cancer (IBC) was conducted in France from September 2001 to April 2002, in order to assess the epidemiological features of newly diagnosed disease, the prognostic and predictive variables with a special emphasis on hormone receptors, and the current approaches to therapy in everyday clinical practice.

RESULTS

In total, 1159 patients were evaluable (median age 57 years); two-thirds of women were postmenopausal and 38% had undergone hormonal replacement therapy (HRT). Ductal and lobular infiltrating cancers represented 82.3% and 11.6% of cases, respectively. Most tumours expressed oestrogen (79.7%) and progesterone (69.7%) receptors. Overexpression of the human epidermal growth factor receptor-2 oncogene was found in 20.6% of the assessed cases. IBC diagnosed in women under HRT presented significantly better clinico-pathological features than in non-users. All patients underwent surgery as first treatment: 77.5% breast-conserving surgery (BCS) and 22.5% mastectomy; 1024 patients also underwent axillary surgery. The overall axillary lymph-node involvement rate was 44.4%. Radiotherapy was proposed in 98% and 83% of the women who had undergone BCS and mastectomy, respectively. Adjuvant chemotherapy was delivered in 58.7% of patients and hormonal treatment was provided in 76.5% of patients; tamoxifen was the most widely used hormonal treatment.

CONCLUSIONS

This study showed a trend for global downstaging of IBC (with favourable clinico-pathological features), leading to a high rate of BCS. Postoperative treatments were widely used, in accordance with national and international guidelines. Use of aromatase inhibitors and taxanes was limited, but is likely to rise in the future.

Authors+Show Affiliations

Department of Oncology and Radiotherapy, Polyclinique de Courlancy, Reims, France. b.cutuli@wanadoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16261401

Citation

Cutuli, Bruno, et al. "A French National Survey On Infiltrating Breast Cancer: Analysis of Clinico-pathological Features and Treatment Modalities in 1159 Patients." Breast Cancer Research and Treatment, vol. 95, no. 1, 2006, pp. 55-64.
Cutuli B, Cottu PH, Guastalla JP, et al. A French national survey on infiltrating breast cancer: analysis of clinico-pathological features and treatment modalities in 1159 patients. Breast Cancer Res Treat. 2006;95(1):55-64.
Cutuli, B., Cottu, P. H., Guastalla, J. P., Mechin, H., Costa, A., & Jourdan, R. (2006). A French national survey on infiltrating breast cancer: analysis of clinico-pathological features and treatment modalities in 1159 patients. Breast Cancer Research and Treatment, 95(1), 55-64.
Cutuli B, et al. A French National Survey On Infiltrating Breast Cancer: Analysis of Clinico-pathological Features and Treatment Modalities in 1159 Patients. Breast Cancer Res Treat. 2006;95(1):55-64. PubMed PMID: 16261401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A French national survey on infiltrating breast cancer: analysis of clinico-pathological features and treatment modalities in 1159 patients. AU - Cutuli,Bruno, AU - Cottu,Paul Henri, AU - Guastalla,Jean Paul, AU - Mechin,Hubert, AU - Costa,Anne, AU - Jourdan,Rosemary, Y1 - 2005/10/27/ PY - 2005/07/08/received PY - 2005/07/19/accepted PY - 2005/11/2/pubmed PY - 2007/1/17/medline PY - 2005/11/2/entrez SP - 55 EP - 64 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 95 IS - 1 N2 - BACKGROUND: Despite the approximate 42,000 yearly new cases of breast cancer in France, there have been very few exhaustive studies on the clinicopathological features and treatment options of this disease. METHODS: Thus, a prospective, non-selective, nationwide survey on infiltrating breast cancer (IBC) was conducted in France from September 2001 to April 2002, in order to assess the epidemiological features of newly diagnosed disease, the prognostic and predictive variables with a special emphasis on hormone receptors, and the current approaches to therapy in everyday clinical practice. RESULTS: In total, 1159 patients were evaluable (median age 57 years); two-thirds of women were postmenopausal and 38% had undergone hormonal replacement therapy (HRT). Ductal and lobular infiltrating cancers represented 82.3% and 11.6% of cases, respectively. Most tumours expressed oestrogen (79.7%) and progesterone (69.7%) receptors. Overexpression of the human epidermal growth factor receptor-2 oncogene was found in 20.6% of the assessed cases. IBC diagnosed in women under HRT presented significantly better clinico-pathological features than in non-users. All patients underwent surgery as first treatment: 77.5% breast-conserving surgery (BCS) and 22.5% mastectomy; 1024 patients also underwent axillary surgery. The overall axillary lymph-node involvement rate was 44.4%. Radiotherapy was proposed in 98% and 83% of the women who had undergone BCS and mastectomy, respectively. Adjuvant chemotherapy was delivered in 58.7% of patients and hormonal treatment was provided in 76.5% of patients; tamoxifen was the most widely used hormonal treatment. CONCLUSIONS: This study showed a trend for global downstaging of IBC (with favourable clinico-pathological features), leading to a high rate of BCS. Postoperative treatments were widely used, in accordance with national and international guidelines. Use of aromatase inhibitors and taxanes was limited, but is likely to rise in the future. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/16261401/A_French_national_survey_on_infiltrating_breast_cancer:_analysis_of_clinico_pathological_features_and_treatment_modalities_in_1159_patients_ L2 - https://doi.org/10.1007/s10549-005-9034-6 DB - PRIME DP - Unbound Medicine ER -