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Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: isolation of emodin and physcion as active antibacterial agents.
Phytother Res. 2005 Oct; 19(10):888-94.PR

Abstract

The antibacterial activity of the extracts of Ventilago madraspatana stem-bark, Rubia cordifolia root and Lantana camara root-bark, prepared with solvents of different polarity, was evaluated by the agar-well diffusion method. Twelve bacteria, six each of gram-positive and gram-negative strains, were used in this study. Chloroform and ethanol extracts of V. madraspatana showed broad-spectrum activity against most of the bacteria except S. aureus, E. coli and V. cholerae. On the other hand, the activity of the chloroform and methanol extracts of R. cordifolia and L. camara was found to be more specific towards the gram-positive strains, although gram-negative P. aeruginosa was also inhibited by the methanol extracts of both these plants in a dose dependent manner. The water extracts of V. madraspatana and L. camara were found to be inactive, while that of R. cordifolia was significantly active against B. subtilis and S. aureus compared with streptomycin and penicillin G used as standards. In the course of bio-assay guided fractionation, emodin and physcion were isolated for the first time from the stem-bark of V. madraspatana. It was noteworthy to find the MICs of emodin in the range 0.5-2.0 microg/mL against three Bacillus sp. Both the anthraquinonoid compounds inhibited P. aeruginosa, emodin being more effective, showing an MIC of 70 microg/mL.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16261521

Citation

Basu, Subhalakshmi, et al. "Evaluation of the Antibacterial Activity of Ventilago Madraspatana Gaertn., Rubia Cordifolia Linn. and Lantana Camara Linn.: Isolation of Emodin and Physcion as Active Antibacterial Agents." Phytotherapy Research : PTR, vol. 19, no. 10, 2005, pp. 888-94.
Basu S, Ghosh A, Hazra B. Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: isolation of emodin and physcion as active antibacterial agents. Phytother Res. 2005;19(10):888-94.
Basu, S., Ghosh, A., & Hazra, B. (2005). Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: isolation of emodin and physcion as active antibacterial agents. Phytotherapy Research : PTR, 19(10), 888-94.
Basu S, Ghosh A, Hazra B. Evaluation of the Antibacterial Activity of Ventilago Madraspatana Gaertn., Rubia Cordifolia Linn. and Lantana Camara Linn.: Isolation of Emodin and Physcion as Active Antibacterial Agents. Phytother Res. 2005;19(10):888-94. PubMed PMID: 16261521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: isolation of emodin and physcion as active antibacterial agents. AU - Basu,Subhalakshmi, AU - Ghosh,Abhijit, AU - Hazra,Banasri, PY - 2005/11/2/pubmed PY - 2005/12/20/medline PY - 2005/11/2/entrez SP - 888 EP - 94 JF - Phytotherapy research : PTR JO - Phytother Res VL - 19 IS - 10 N2 - The antibacterial activity of the extracts of Ventilago madraspatana stem-bark, Rubia cordifolia root and Lantana camara root-bark, prepared with solvents of different polarity, was evaluated by the agar-well diffusion method. Twelve bacteria, six each of gram-positive and gram-negative strains, were used in this study. Chloroform and ethanol extracts of V. madraspatana showed broad-spectrum activity against most of the bacteria except S. aureus, E. coli and V. cholerae. On the other hand, the activity of the chloroform and methanol extracts of R. cordifolia and L. camara was found to be more specific towards the gram-positive strains, although gram-negative P. aeruginosa was also inhibited by the methanol extracts of both these plants in a dose dependent manner. The water extracts of V. madraspatana and L. camara were found to be inactive, while that of R. cordifolia was significantly active against B. subtilis and S. aureus compared with streptomycin and penicillin G used as standards. In the course of bio-assay guided fractionation, emodin and physcion were isolated for the first time from the stem-bark of V. madraspatana. It was noteworthy to find the MICs of emodin in the range 0.5-2.0 microg/mL against three Bacillus sp. Both the anthraquinonoid compounds inhibited P. aeruginosa, emodin being more effective, showing an MIC of 70 microg/mL. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/16261521/Evaluation_of_the_antibacterial_activity_of_Ventilago_madraspatana_Gaertn__Rubia_cordifolia_Linn__and_Lantana_camara_Linn_:_isolation_of_emodin_and_physcion_as_active_antibacterial_agents_ L2 - https://doi.org/10.1002/ptr.1752 DB - PRIME DP - Unbound Medicine ER -