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Dissociable effects of hippocampus lesions on expression of fear and trace fear conditioning memories in rats.
Hippocampus. 2006; 16(2):103-13.H

Abstract

The role of the hippocampus in memory is commonly investigated by comparing fear conditioning paradigms that differ in their reliance on the hippocampus. For example, the dorsal (septal) portion of the hippocampus is involved in trace, but not delay fear conditioning, two Pavlovian paradigms in which only the relative timing of stimulus presentation is varied. However, a growing literature implicates the ventral (temporal) portion of the hippocampus in the expression of fear, irrespective of prior training. The current experiments evaluated the relative contributions of the dorsal and ventral portions of the hippocampus to trace fear conditioning specifically vs. the expression of conditioned fear in general. Lesions restricted to the dorsal hippocampus blocked acquisition of trace fear conditioning. Larger lesions, also including an adjacent portion of the ventral hippocampus, were required to impair retrieval of trace fear conditioning. Delay fear conditioning was not disrupted in either case. In contrast, lesions that encompassed almost the entire dorsal and ventral hippocampus disrupted expression of both trace and delay fear conditioning. The current data suggest distinct roles in fear conditioning for three regions of the hippocampus: the septal zone is required for acquisition of trace fear conditioning, a larger portion of the hippocampus is critical for memory retrieval, and a region including the temporal zone is required for expression of both trace and delay fear conditioning. These findings are consistent with evidence suggesting the neuroanatomical and functional segregation of the hippocampus into three zones along its septal-temporal axis.

Authors+Show Affiliations

Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16261555

Citation

Burman, Michael A., et al. "Dissociable Effects of Hippocampus Lesions On Expression of Fear and Trace Fear Conditioning Memories in Rats." Hippocampus, vol. 16, no. 2, 2006, pp. 103-13.
Burman MA, Starr MJ, Gewirtz JC. Dissociable effects of hippocampus lesions on expression of fear and trace fear conditioning memories in rats. Hippocampus. 2006;16(2):103-13.
Burman, M. A., Starr, M. J., & Gewirtz, J. C. (2006). Dissociable effects of hippocampus lesions on expression of fear and trace fear conditioning memories in rats. Hippocampus, 16(2), 103-13.
Burman MA, Starr MJ, Gewirtz JC. Dissociable Effects of Hippocampus Lesions On Expression of Fear and Trace Fear Conditioning Memories in Rats. Hippocampus. 2006;16(2):103-13. PubMed PMID: 16261555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dissociable effects of hippocampus lesions on expression of fear and trace fear conditioning memories in rats. AU - Burman,Michael A, AU - Starr,Mark J, AU - Gewirtz,Jonathan C, PY - 2005/11/2/pubmed PY - 2006/4/6/medline PY - 2005/11/2/entrez SP - 103 EP - 13 JF - Hippocampus JO - Hippocampus VL - 16 IS - 2 N2 - The role of the hippocampus in memory is commonly investigated by comparing fear conditioning paradigms that differ in their reliance on the hippocampus. For example, the dorsal (septal) portion of the hippocampus is involved in trace, but not delay fear conditioning, two Pavlovian paradigms in which only the relative timing of stimulus presentation is varied. However, a growing literature implicates the ventral (temporal) portion of the hippocampus in the expression of fear, irrespective of prior training. The current experiments evaluated the relative contributions of the dorsal and ventral portions of the hippocampus to trace fear conditioning specifically vs. the expression of conditioned fear in general. Lesions restricted to the dorsal hippocampus blocked acquisition of trace fear conditioning. Larger lesions, also including an adjacent portion of the ventral hippocampus, were required to impair retrieval of trace fear conditioning. Delay fear conditioning was not disrupted in either case. In contrast, lesions that encompassed almost the entire dorsal and ventral hippocampus disrupted expression of both trace and delay fear conditioning. The current data suggest distinct roles in fear conditioning for three regions of the hippocampus: the septal zone is required for acquisition of trace fear conditioning, a larger portion of the hippocampus is critical for memory retrieval, and a region including the temporal zone is required for expression of both trace and delay fear conditioning. These findings are consistent with evidence suggesting the neuroanatomical and functional segregation of the hippocampus into three zones along its septal-temporal axis. SN - 1050-9631 UR - https://www.unboundmedicine.com/medline/citation/16261555/Dissociable_effects_of_hippocampus_lesions_on_expression_of_fear_and_trace_fear_conditioning_memories_in_rats_ L2 - https://doi.org/10.1002/hipo.20137 DB - PRIME DP - Unbound Medicine ER -