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Compulsive eating and weight gain related to dopamine agonist use.
Mov Disord. 2006 Apr; 21(4):524-9.MD

Abstract

Dopamine agonists have been implicated in causing compulsive behaviors in patients with Parkinson's disease (PD). These have included gambling, hypersexuality, hobbyism, and other repetitive, purposeless behaviors ("punding"). In this report, we describe 7 patients in whom compulsive eating developed in the context of pramipexole use. All of the affected patients had significant, undesired weight gain; 4 had other comorbid compulsive behaviors. In the 5 patients who lowered the dose of pramipexole or discontinued dopamine agonist treatment, the behavior remitted and no further weight gain occurred. Physicians should be aware that compulsive eating resulting in significant weight gain may occur in PD as a side-effect of dopamine agonist medications such as pramipexole. Given the known risks of the associated weight gain and obesity, further investigation is warranted.

Authors+Show Affiliations

Division of Movement Disorders, Department of Neurology, Columbia University Medical Center, New York, NY 10021, USA. mjnirenb@med.cornell.eduNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

16261618

Citation

Nirenberg, Melissa J., and Cheryl Waters. "Compulsive Eating and Weight Gain Related to Dopamine Agonist Use." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 4, 2006, pp. 524-9.
Nirenberg MJ, Waters C. Compulsive eating and weight gain related to dopamine agonist use. Mov Disord. 2006;21(4):524-9.
Nirenberg, M. J., & Waters, C. (2006). Compulsive eating and weight gain related to dopamine agonist use. Movement Disorders : Official Journal of the Movement Disorder Society, 21(4), 524-9.
Nirenberg MJ, Waters C. Compulsive Eating and Weight Gain Related to Dopamine Agonist Use. Mov Disord. 2006;21(4):524-9. PubMed PMID: 16261618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compulsive eating and weight gain related to dopamine agonist use. AU - Nirenberg,Melissa J, AU - Waters,Cheryl, PY - 2005/11/2/pubmed PY - 2006/9/27/medline PY - 2005/11/2/entrez SP - 524 EP - 9 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 21 IS - 4 N2 - Dopamine agonists have been implicated in causing compulsive behaviors in patients with Parkinson's disease (PD). These have included gambling, hypersexuality, hobbyism, and other repetitive, purposeless behaviors ("punding"). In this report, we describe 7 patients in whom compulsive eating developed in the context of pramipexole use. All of the affected patients had significant, undesired weight gain; 4 had other comorbid compulsive behaviors. In the 5 patients who lowered the dose of pramipexole or discontinued dopamine agonist treatment, the behavior remitted and no further weight gain occurred. Physicians should be aware that compulsive eating resulting in significant weight gain may occur in PD as a side-effect of dopamine agonist medications such as pramipexole. Given the known risks of the associated weight gain and obesity, further investigation is warranted. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/16261618/Compulsive_eating_and_weight_gain_related_to_dopamine_agonist_use_ L2 - https://doi.org/10.1002/mds.20757 DB - PRIME DP - Unbound Medicine ER -