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Multivariate analysis of relationships between iodine biological exposure and subclinical thyroid dysfunctions.
Chin Med Sci J 2005; 20(3):202-5CM

Abstract

OBJECTIVE

To assess the relationships between iodine biological exposure and subclinical thyroid dysfunctions.

METHODS

The cross-sectional survey was performed to obtain the epidemiologic data of population in three communities with different iodine biological exposure: mild iodine deficiency [median urinary iodine concentration (MUI) of 50-99 microg/L], more than adequate iodine intake (MUI of 200-299 microg/L), and excessive iodine intake (MUI over 300 microg/L). Univariate and multivariate analysis (logistic regression analysis) were used to analyze the risk factors of subclinical hypothyroidism and subclinical hyperthyroidism.

RESULTS

Logistic regression analysis with sex and age controlled suggested that more than adequate iodine intake (OR = 3.172, P = 0.0004) and excessive iodine intake (OR = 6.391, P = 0.0001) increased the risk of subclinical hypothyroidism, while excessive iodine intake decreased the risk of subclinical hyperthyroidism (OR = 0.218, P = 0.0001). Logistic regression analysis including interaction of iodine intake and antibodies [thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb)] suggested that excessive iodine intake was an independent risk factor of subclinical hypothyroidism (OR = 6.360, P = 0.0001), but independent protect factor of subclinical hyperthyroidism (OR = 0.193, P = 0.0001). More than adequate iodine intake and it's interaction with TgAb increased the risk of subclinical hypothyroidism independently, in addition, it decreased the risk of subclinical hyperthyroidism at the present of TPOAb.

CONCLUSION

Both excessive iodine intake and more than adequate iodine intake could increase risk of subclinical hypothyroidism, supplement of iodine should be controlled to ensure MUI within the safe range.

Authors+Show Affiliations

Department of Emergency, First Affiliated Hospital, China Medical University, Shenyang 110001.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16261894

Citation

Chong, Wei, et al. "Multivariate Analysis of Relationships Between Iodine Biological Exposure and Subclinical Thyroid Dysfunctions." Chinese Medical Sciences Journal = Chung-kuo I Hsueh K'o Hsueh Tsa Chih, vol. 20, no. 3, 2005, pp. 202-5.
Chong W, Shan ZY, Sun W, et al. Multivariate analysis of relationships between iodine biological exposure and subclinical thyroid dysfunctions. Chin Med Sci J. 2005;20(3):202-5.
Chong, W., Shan, Z. Y., Sun, W., & Teng, W. P. (2005). Multivariate analysis of relationships between iodine biological exposure and subclinical thyroid dysfunctions. Chinese Medical Sciences Journal = Chung-kuo I Hsueh K'o Hsueh Tsa Chih, 20(3), pp. 202-5.
Chong W, et al. Multivariate Analysis of Relationships Between Iodine Biological Exposure and Subclinical Thyroid Dysfunctions. Chin Med Sci J. 2005;20(3):202-5. PubMed PMID: 16261894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multivariate analysis of relationships between iodine biological exposure and subclinical thyroid dysfunctions. AU - Chong,Wei, AU - Shan,Zhong-Yan, AU - Sun,Wei, AU - Teng,Wei-Ping, PY - 2005/11/3/pubmed PY - 2006/12/23/medline PY - 2005/11/3/entrez SP - 202 EP - 5 JF - Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih JO - Chin. Med. Sci. J. VL - 20 IS - 3 N2 - OBJECTIVE: To assess the relationships between iodine biological exposure and subclinical thyroid dysfunctions. METHODS: The cross-sectional survey was performed to obtain the epidemiologic data of population in three communities with different iodine biological exposure: mild iodine deficiency [median urinary iodine concentration (MUI) of 50-99 microg/L], more than adequate iodine intake (MUI of 200-299 microg/L), and excessive iodine intake (MUI over 300 microg/L). Univariate and multivariate analysis (logistic regression analysis) were used to analyze the risk factors of subclinical hypothyroidism and subclinical hyperthyroidism. RESULTS: Logistic regression analysis with sex and age controlled suggested that more than adequate iodine intake (OR = 3.172, P = 0.0004) and excessive iodine intake (OR = 6.391, P = 0.0001) increased the risk of subclinical hypothyroidism, while excessive iodine intake decreased the risk of subclinical hyperthyroidism (OR = 0.218, P = 0.0001). Logistic regression analysis including interaction of iodine intake and antibodies [thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb)] suggested that excessive iodine intake was an independent risk factor of subclinical hypothyroidism (OR = 6.360, P = 0.0001), but independent protect factor of subclinical hyperthyroidism (OR = 0.193, P = 0.0001). More than adequate iodine intake and it's interaction with TgAb increased the risk of subclinical hypothyroidism independently, in addition, it decreased the risk of subclinical hyperthyroidism at the present of TPOAb. CONCLUSION: Both excessive iodine intake and more than adequate iodine intake could increase risk of subclinical hypothyroidism, supplement of iodine should be controlled to ensure MUI within the safe range. SN - 1001-9294 UR - https://www.unboundmedicine.com/medline/citation/16261894/Multivariate_analysis_of_relationships_between_iodine_biological_exposure_and_subclinical_thyroid_dysfunctions_ L2 - https://medlineplus.gov/hyperthyroidism.html DB - PRIME DP - Unbound Medicine ER -