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Relaxin receptor activation in the basolateral amygdala impairs memory consolidation.
Eur J Neurosci. 2005 Oct; 22(8):2117-22.EJ

Abstract

The peptide-hormone relaxin has well-established actions in male and female reproductive tracts, and has functional effects in circumventricular regions of brain involved in neurohormonal secretion. In the current study, we initially mapped the distribution of mRNA encoding the relaxin receptor--leucine-rich repeat-containing G-protein-coupled receptor 7 (LGR7)- and [33P]-human relaxin-binding sites in extra-hypothalamic sites of male Sprague-Dawley rats. The basolateral amygdala (BLA) expressed high levels of LGR7 mRNA and relaxin-binding sites and, although relaxin peptide was not detected in the BLA, several brain regions that send projections to the BLA were found to contain relaxin-expressing neurons. As it is well established that the BLA is involved in regulating the consolidation of memory for emotionally arousing experiences, we investigated whether activation of LGR7 in the BLA modulated memory consolidation for aversively motivated inhibitory avoidance training. Bilateral infusions of human relaxin (10-200 ng in 0.2 microL) into the BLA immediately after inhibitory avoidance training impaired 48-h retention performance in a dose-dependent manner. Delayed infusions of relaxin into the BLA 3 h after training were ineffective, indicating that the retention impairment was due to influences on memory consolidation. Post-training infusions of relaxin into the adjacent central amygdala, which is devoid of LGR7, did not impair retention. These findings suggest a novel function for endogenous relaxin-LGR7 signalling in rat brain involving regulation of memory consolidation.

Authors+Show Affiliations

Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Victoria 3010, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16262650

Citation

Ma, Sherie, et al. "Relaxin Receptor Activation in the Basolateral Amygdala Impairs Memory Consolidation." The European Journal of Neuroscience, vol. 22, no. 8, 2005, pp. 2117-22.
Ma S, Roozendaal B, Burazin TC, et al. Relaxin receptor activation in the basolateral amygdala impairs memory consolidation. Eur J Neurosci. 2005;22(8):2117-22.
Ma, S., Roozendaal, B., Burazin, T. C., Tregear, G. W., McGaugh, J. L., & Gundlach, A. L. (2005). Relaxin receptor activation in the basolateral amygdala impairs memory consolidation. The European Journal of Neuroscience, 22(8), 2117-22.
Ma S, et al. Relaxin Receptor Activation in the Basolateral Amygdala Impairs Memory Consolidation. Eur J Neurosci. 2005;22(8):2117-22. PubMed PMID: 16262650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relaxin receptor activation in the basolateral amygdala impairs memory consolidation. AU - Ma,Sherie, AU - Roozendaal,Benno, AU - Burazin,Tanya C D, AU - Tregear,Geoffrey W, AU - McGaugh,James L, AU - Gundlach,Andrew L, PY - 2005/11/3/pubmed PY - 2005/12/16/medline PY - 2005/11/3/entrez SP - 2117 EP - 22 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 22 IS - 8 N2 - The peptide-hormone relaxin has well-established actions in male and female reproductive tracts, and has functional effects in circumventricular regions of brain involved in neurohormonal secretion. In the current study, we initially mapped the distribution of mRNA encoding the relaxin receptor--leucine-rich repeat-containing G-protein-coupled receptor 7 (LGR7)- and [33P]-human relaxin-binding sites in extra-hypothalamic sites of male Sprague-Dawley rats. The basolateral amygdala (BLA) expressed high levels of LGR7 mRNA and relaxin-binding sites and, although relaxin peptide was not detected in the BLA, several brain regions that send projections to the BLA were found to contain relaxin-expressing neurons. As it is well established that the BLA is involved in regulating the consolidation of memory for emotionally arousing experiences, we investigated whether activation of LGR7 in the BLA modulated memory consolidation for aversively motivated inhibitory avoidance training. Bilateral infusions of human relaxin (10-200 ng in 0.2 microL) into the BLA immediately after inhibitory avoidance training impaired 48-h retention performance in a dose-dependent manner. Delayed infusions of relaxin into the BLA 3 h after training were ineffective, indicating that the retention impairment was due to influences on memory consolidation. Post-training infusions of relaxin into the adjacent central amygdala, which is devoid of LGR7, did not impair retention. These findings suggest a novel function for endogenous relaxin-LGR7 signalling in rat brain involving regulation of memory consolidation. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/16262650/Relaxin_receptor_activation_in_the_basolateral_amygdala_impairs_memory_consolidation_ L2 - https://doi.org/10.1111/j.1460-9568.2005.04374.x DB - PRIME DP - Unbound Medicine ER -