TY - JOUR T1 - Associations of uric acid with polymorphisms in the delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead workers. AU - Weaver,Virginia M, AU - Schwartz,Brian S, AU - Jaar,Bernard G, AU - Ahn,Kyu-Dong, AU - Todd,Andrew C, AU - Lee,Sung-Soo, AU - Kelsey,Karl T, AU - Silbergeld,Ellen K, AU - Lustberg,Mark E, AU - Parsons,Patrick J, AU - Wen,Jiayu, AU - Lee,Byung-Kook, PY - 2005/11/3/pubmed PY - 2006/1/27/medline PY - 2005/11/3/entrez SP - 1509 EP - 15 JF - Environmental health perspectives JO - Environ Health Perspect VL - 113 IS - 11 N2 - Recent research suggests that uric acid may be nephrotoxic at lower levels than previously recognized and that it may be one mechanism for lead-related nephrotoxicity. Therefore, in understanding mechanisms for lead-related nephrotoxicity, it would be of value to determine whether genetic polymorphisms that are associated with renal outcomes in lead workers and/or modify associations between lead dose and renal function are also associated with uric acid and/or modify associations between lead dose and uric acid. We analyzed data on three such genetic polymorphisms: delta-aminolevulinic acid dehydratase (ALAD), endothelial nitric oxide synthase (eNOS), and the vitamin D receptor (VDR). Mean (+/- SD) tibia, blood, and dimercaptosuccinic acid-chelatable lead levels were 37.2 +/- 40.4 microg/g bone mineral, 32.0+/- 15.0 g/dL, and 0.77+/- 0.86 microg/mg creatinine, respectively, in 798 current and former lead workers. Participants with the eNOSAsp allele had lower mean serum uric acid compared with those with the Glu/Glu genotype. Among older workers (age > or = median of 40.6 years), ALAD genotype modified associations between lead dose and uric acid levels. Higher lead dose was significantly associated with higher uric acid in workers with the ALAD1-1 genotype; associations were in the opposite direction in participants with the variant ALAD1-2 genotype. In contrast, higher tibia lead was associated with higher uric acid in those with the variant VDRB allele; however, modification was dependent on participants with the bb genotype and high tibia lead levels. We conclude that genetic polymorphisms may modify uric acid mediation of lead-related adverse renal effects. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/16263504/Associations_of_uric_acid_with_polymorphisms_in_the_delta_aminolevulinic_acid_dehydratase_vitamin_D_receptor_and_nitric_oxide_synthase_genes_in_Korean_lead_workers_ DB - PRIME DP - Unbound Medicine ER -