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Alcohol and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status: a prospective cohort study.

Abstract

BACKGROUND

Alcohol intake has been reported to be positively associated with an increased risk of postmenopausal breast cancer; however, the association with the estrogen receptor (ER) and progesterone receptor (PR) status of the breast tumors remains unclear.

METHODS

Self-reported data on alcohol consumption were collected in 1987 and 1997 from 51,847 postmenopausal women in the population-based Swedish Mammography Cohort. Through June 30, 2004, 1188 invasive breast cancer case patients with known ER and PR status were identified during an average 8.3-year follow-up. We used Cox proportional hazards models to estimate multivariable relative risks (RRs) of breast cancer, adjusting for age; family history of breast cancer; body mass index; height; parity; age at menarche, first birth, and menopause; education level; use of postmenopausal hormones; and diet. Heterogeneity among groups was evaluated using the Wald test. All statistical tests were two-sided.

RESULTS

Alcohol consumption was associated with an increased risk for the development of ER-positive (+) tumors, irrespective of PR status (highest intake [> or = 10 g of alcohol per day] versus nondrinkers, multivariable RR = 1.35, 95% confidence interval [CI] = 1.02 to 1.80; Ptrend < .049 for ER+PR+ tumors; and RR = 2.36, 95% CI = 1.56 to 3.56; Ptrend < .001 for ER+PR-tumors). The absolute rate of ER+ breast cancer (standardized to the age distribution of person-years experienced by all study participants using 5-year age categories) was 232 per 100,000 person-years among women in the highest category of alcohol intake, and 158 per 100,000 person-years among nondrinkers. No association was observed between alcohol intake and the risk of developing ER-tumors. Furthermore, we observed a statistically significant interaction between alcohol intake and the use of postmenopausal hormones on the risk for ER+PR+ tumors (Pinteraction = .039).

CONCLUSION

The observed association between risk of developing postmenopausal ER+ breast cancer and alcohol drinking, especially among those women who use postmenopausal hormones, may be important, because the majority of breast tumors among postmenopausal women overexpress ER.

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  • Authors+Show Affiliations

    ,

    The National Institute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden.

    , , , ,

    Source

    Journal of the National Cancer Institute 97:21 2005 Nov 02 pg 1601-8

    MeSH

    Aged
    Alcohol Drinking
    Breast Neoplasms
    Case-Control Studies
    Cohort Studies
    Confounding Factors (Epidemiology)
    Female
    Humans
    Mammography
    Middle Aged
    Multivariate Analysis
    Postmenopause
    Proportional Hazards Models
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    Research Design
    Risk Assessment
    Risk Factors
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16264180

    Citation

    Suzuki, Reiko, et al. "Alcohol and Postmenopausal Breast Cancer Risk Defined By Estrogen and Progesterone Receptor Status: a Prospective Cohort Study." Journal of the National Cancer Institute, vol. 97, no. 21, 2005, pp. 1601-8.
    Suzuki R, Ye W, Rylander-Rudqvist T, et al. Alcohol and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status: a prospective cohort study. J Natl Cancer Inst. 2005;97(21):1601-8.
    Suzuki, R., Ye, W., Rylander-Rudqvist, T., Saji, S., Colditz, G. A., & Wolk, A. (2005). Alcohol and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status: a prospective cohort study. Journal of the National Cancer Institute, 97(21), pp. 1601-8.
    Suzuki R, et al. Alcohol and Postmenopausal Breast Cancer Risk Defined By Estrogen and Progesterone Receptor Status: a Prospective Cohort Study. J Natl Cancer Inst. 2005 Nov 2;97(21):1601-8. PubMed PMID: 16264180.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status: a prospective cohort study. AU - Suzuki,Reiko, AU - Ye,Weimin, AU - Rylander-Rudqvist,Tove, AU - Saji,Shigehira, AU - Colditz,Graham A, AU - Wolk,Alicja, PY - 2005/11/3/pubmed PY - 2005/12/13/medline PY - 2005/11/3/entrez SP - 1601 EP - 8 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 97 IS - 21 N2 - BACKGROUND: Alcohol intake has been reported to be positively associated with an increased risk of postmenopausal breast cancer; however, the association with the estrogen receptor (ER) and progesterone receptor (PR) status of the breast tumors remains unclear. METHODS: Self-reported data on alcohol consumption were collected in 1987 and 1997 from 51,847 postmenopausal women in the population-based Swedish Mammography Cohort. Through June 30, 2004, 1188 invasive breast cancer case patients with known ER and PR status were identified during an average 8.3-year follow-up. We used Cox proportional hazards models to estimate multivariable relative risks (RRs) of breast cancer, adjusting for age; family history of breast cancer; body mass index; height; parity; age at menarche, first birth, and menopause; education level; use of postmenopausal hormones; and diet. Heterogeneity among groups was evaluated using the Wald test. All statistical tests were two-sided. RESULTS: Alcohol consumption was associated with an increased risk for the development of ER-positive (+) tumors, irrespective of PR status (highest intake [> or = 10 g of alcohol per day] versus nondrinkers, multivariable RR = 1.35, 95% confidence interval [CI] = 1.02 to 1.80; Ptrend < .049 for ER+PR+ tumors; and RR = 2.36, 95% CI = 1.56 to 3.56; Ptrend < .001 for ER+PR-tumors). The absolute rate of ER+ breast cancer (standardized to the age distribution of person-years experienced by all study participants using 5-year age categories) was 232 per 100,000 person-years among women in the highest category of alcohol intake, and 158 per 100,000 person-years among nondrinkers. No association was observed between alcohol intake and the risk of developing ER-tumors. Furthermore, we observed a statistically significant interaction between alcohol intake and the use of postmenopausal hormones on the risk for ER+PR+ tumors (Pinteraction = .039). CONCLUSION: The observed association between risk of developing postmenopausal ER+ breast cancer and alcohol drinking, especially among those women who use postmenopausal hormones, may be important, because the majority of breast tumors among postmenopausal women overexpress ER. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/16264180/Alcohol_and_postmenopausal_breast_cancer_risk_defined_by_estrogen_and_progesterone_receptor_status:_a_prospective_cohort_study_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/dji341 DB - PRIME DP - Unbound Medicine ER -