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Relation of acute-phase reaction and endothelial activation to insulin resistance and adiposity in obese children and adolescents.
Neuro Endocrinol Lett. 2005 Oct; 26(5):473-9.NE

Abstract

OBJECTIVES

There is increasing evidence that an ongoing cytokine-induced acute-phase response is closely involved in the pathogenesis of type 2 diabetes and associated complications such as dyslipidemia and atherosclerosis. The aim of this study was to investigate the relationship of inflammation and endothelial activation with insulin resistance in childhood obesity.

METHODS

Two hundred and eleven (122 boys) obese children and adolescents were examined. Fasting levels of ultra-sensitive C-reactive protein (CRP), fibrinogen (FB), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), von Willebrand factor (vWF), glucose, insulin, and HbA1c were determined. Insulin resistance was assessed by the homeostasis method.

RESULTS

HOMA IR correlated significantly with all measures of adiposity as well as with majority of inflammation and endothelial dysfunction markers. After adjustment for age, gender, BMI and fat mass, the correlation with insulin resistance remained significant for CRP, ICAM-1 and von Willebrand factor. There was a trend for association between HOMA IR and IL-6 as well as HOMA IR and fibrinogen.

CONCLUSION

Acute-phase reaction and endothelial activation correlate with insulin resistance in obese youth. It is possible that the cluster of these pro-atherogenic factors may contribute to the accelerated atherosclerosis in obese children.

Authors+Show Affiliations

Independent Laboratory of Propedeutics of Children's Diseases, Pomeranian Medical University, Szczecin, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16264416

Citation

Garanty-Bogacka, Barbara, et al. "Relation of Acute-phase Reaction and Endothelial Activation to Insulin Resistance and Adiposity in Obese Children and Adolescents." Neuro Endocrinology Letters, vol. 26, no. 5, 2005, pp. 473-9.
Garanty-Bogacka B, Syrenicz M, Syrenicz A, et al. Relation of acute-phase reaction and endothelial activation to insulin resistance and adiposity in obese children and adolescents. Neuro Endocrinol Lett. 2005;26(5):473-9.
Garanty-Bogacka, B., Syrenicz, M., Syrenicz, A., Gebala, A., & Walczak, M. (2005). Relation of acute-phase reaction and endothelial activation to insulin resistance and adiposity in obese children and adolescents. Neuro Endocrinology Letters, 26(5), 473-9.
Garanty-Bogacka B, et al. Relation of Acute-phase Reaction and Endothelial Activation to Insulin Resistance and Adiposity in Obese Children and Adolescents. Neuro Endocrinol Lett. 2005;26(5):473-9. PubMed PMID: 16264416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of acute-phase reaction and endothelial activation to insulin resistance and adiposity in obese children and adolescents. AU - Garanty-Bogacka,Barbara, AU - Syrenicz,Małgorzata, AU - Syrenicz,Anhelli, AU - Gebala,Aneta, AU - Walczak,Mieczysław, PY - 2005/10/05/received PY - 2005/10/10/accepted PY - 2005/11/3/pubmed PY - 2006/3/18/medline PY - 2005/11/3/entrez SP - 473 EP - 9 JF - Neuro endocrinology letters JO - Neuro Endocrinol. Lett. VL - 26 IS - 5 N2 - OBJECTIVES: There is increasing evidence that an ongoing cytokine-induced acute-phase response is closely involved in the pathogenesis of type 2 diabetes and associated complications such as dyslipidemia and atherosclerosis. The aim of this study was to investigate the relationship of inflammation and endothelial activation with insulin resistance in childhood obesity. METHODS: Two hundred and eleven (122 boys) obese children and adolescents were examined. Fasting levels of ultra-sensitive C-reactive protein (CRP), fibrinogen (FB), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), von Willebrand factor (vWF), glucose, insulin, and HbA1c were determined. Insulin resistance was assessed by the homeostasis method. RESULTS: HOMA IR correlated significantly with all measures of adiposity as well as with majority of inflammation and endothelial dysfunction markers. After adjustment for age, gender, BMI and fat mass, the correlation with insulin resistance remained significant for CRP, ICAM-1 and von Willebrand factor. There was a trend for association between HOMA IR and IL-6 as well as HOMA IR and fibrinogen. CONCLUSION: Acute-phase reaction and endothelial activation correlate with insulin resistance in obese youth. It is possible that the cluster of these pro-atherogenic factors may contribute to the accelerated atherosclerosis in obese children. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/16264416/Relation_of_acute_phase_reaction_and_endothelial_activation_to_insulin_resistance_and_adiposity_in_obese_children_and_adolescents_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -