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Coinfection with HIV and hepatitis C virus among injection drug users in southern China.
Clin Infect Dis. 2005 Jul 01; 41 Suppl 1:S18-24.CI

Abstract

BACKGROUND

We sought to examine coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) among injection drug users (IDUs) in Guangxi, China.

METHODS

A longitudinal cohort of IDUs (547 subjects) was established to study risk factors for bloodborne infections. At each visit, participants completed questionnaires defining demographic characteristics, patterns of drug use, and sexual behaviors. Blood samples were collected and analyzed for the presence and genotype of HIV and HCV.

RESULTS

Coinfection with HIV and HCV was found in 17.6% of the IDUs. HCV was present in 95.1% of HIV-positive and 70.4% of HIV-negative heroin users. The prevalence of HIV in HCV-positive and HCV-negative heroin users was 23.4% and 3.6%, respectively. Multivariate logistic regression analysis revealed that sexual activity during the past 6 months and duration of injection drug use were significantly associated with coinfection with HIV and HCV. The main circulating HCV genotypes included 6a (38%), 3b (37%), and 1a (19%), whereas genotypes 6e (4%), 3a (2%), and 1b (1%) were present in only a few IDUs. Multiple HCV genotypes were present at each study site and did not segregate by HIV status or subtype.

CONCLUSIONS

HCV is highly prevalent in IDUs throughout southern China. In Guangxi, HIV infections are the result of parenteral and sexual transmission, and, therefore, all IDUs are at high risk of coinfection with HIV and HCV. Molecular tracking of HCV may be a more sensitive predictor of the future spread of the HIV-1 epidemic than is HIV subtyping. This study emphasizes that, without implementation of injection prevention and primary substance abuse programs in China, the extent and effect of coinfection with HIV and HCV will only increase.

Authors+Show Affiliations

Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16265609

Citation

Garten, Rebecca J., et al. "Coinfection With HIV and Hepatitis C Virus Among Injection Drug Users in Southern China." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 41 Suppl 1, 2005, pp. S18-24.
Garten RJ, Zhang J, Lai S, et al. Coinfection with HIV and hepatitis C virus among injection drug users in southern China. Clin Infect Dis. 2005;41 Suppl 1:S18-24.
Garten, R. J., Zhang, J., Lai, S., Liu, W., Chen, J., & Yu, X. F. (2005). Coinfection with HIV and hepatitis C virus among injection drug users in southern China. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 41 Suppl 1, S18-24.
Garten RJ, et al. Coinfection With HIV and Hepatitis C Virus Among Injection Drug Users in Southern China. Clin Infect Dis. 2005 Jul 1;41 Suppl 1:S18-24. PubMed PMID: 16265609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coinfection with HIV and hepatitis C virus among injection drug users in southern China. AU - Garten,Rebecca J, AU - Zhang,Jinbing, AU - Lai,Shenghan, AU - Liu,Wei, AU - Chen,Jie, AU - Yu,Xiao-Fang, PY - 2005/11/3/pubmed PY - 2007/2/16/medline PY - 2005/11/3/entrez SP - S18 EP - 24 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 41 Suppl 1 N2 - BACKGROUND: We sought to examine coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) among injection drug users (IDUs) in Guangxi, China. METHODS: A longitudinal cohort of IDUs (547 subjects) was established to study risk factors for bloodborne infections. At each visit, participants completed questionnaires defining demographic characteristics, patterns of drug use, and sexual behaviors. Blood samples were collected and analyzed for the presence and genotype of HIV and HCV. RESULTS: Coinfection with HIV and HCV was found in 17.6% of the IDUs. HCV was present in 95.1% of HIV-positive and 70.4% of HIV-negative heroin users. The prevalence of HIV in HCV-positive and HCV-negative heroin users was 23.4% and 3.6%, respectively. Multivariate logistic regression analysis revealed that sexual activity during the past 6 months and duration of injection drug use were significantly associated with coinfection with HIV and HCV. The main circulating HCV genotypes included 6a (38%), 3b (37%), and 1a (19%), whereas genotypes 6e (4%), 3a (2%), and 1b (1%) were present in only a few IDUs. Multiple HCV genotypes were present at each study site and did not segregate by HIV status or subtype. CONCLUSIONS: HCV is highly prevalent in IDUs throughout southern China. In Guangxi, HIV infections are the result of parenteral and sexual transmission, and, therefore, all IDUs are at high risk of coinfection with HIV and HCV. Molecular tracking of HCV may be a more sensitive predictor of the future spread of the HIV-1 epidemic than is HIV subtyping. This study emphasizes that, without implementation of injection prevention and primary substance abuse programs in China, the extent and effect of coinfection with HIV and HCV will only increase. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/16265609/Coinfection_with_HIV_and_hepatitis_C_virus_among_injection_drug_users_in_southern_China_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/429491 DB - PRIME DP - Unbound Medicine ER -