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[New results in the management of hypercholesterolemia].
Orv Hetil 2005; 146(39):1999-2004OH

Abstract

Cardiovascular disease is a major cause of morbidity and mortality worldwide. During the last decade huge amount of laboratory and clinical evidence proved link between serum lipid concentration and the development of coronary heart disease. The Adult Treatment Panel III of the National Cholesterol Education Program issued an evidence-based set of guidelines on cholesterol management. Since the publication of these guidelines numbers of new clinical trials and experimental results have been published. Recently completed clinical trials have indicated that reduction of low-density lipoprotein cholesterol to goals lower than the previously considered appropriate 2,6 mmol/l, produce further cardiovascular risk reduction in high risk individuals. There is growing evidence of the role of inflammation in the development of atherosclerosis and cardiovascular disease. Numerous studies have demonstrated that elevated C-reactive protein may be an independent cardiovascular risk factor. Statin therapy has produced a greater cardiovascular risk reduction in those patients whose C-reactive protein level was high. Ezetimibe is a new intestinal cholesterol uptake inhibitor, which reduces LDL cholesterol in monotherapy or in combination with statins. Lately a variety of new antilipemic agents are being developed. The present review summarizes some of these new results and their effect on cholesterol lowering therapy.

Authors+Show Affiliations

Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika, Budapest. sarbea@bel2.sote.hu

Pub Type(s)

English Abstract
Journal Article
Review

Language

hun

PubMed ID

16265867

Citation

Sármán, Beatrix. "[New Results in the Management of Hypercholesterolemia]." Orvosi Hetilap, vol. 146, no. 39, 2005, pp. 1999-2004.
Sármán B. [New results in the management of hypercholesterolemia]. Orv Hetil. 2005;146(39):1999-2004.
Sármán, B. (2005). [New results in the management of hypercholesterolemia]. Orvosi Hetilap, 146(39), pp. 1999-2004.
Sármán B. [New Results in the Management of Hypercholesterolemia]. Orv Hetil. 2005 Sep 25;146(39):1999-2004. PubMed PMID: 16265867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [New results in the management of hypercholesterolemia]. A1 - Sármán,Beatrix, PY - 2005/11/4/pubmed PY - 2005/12/22/medline PY - 2005/11/4/entrez SP - 1999 EP - 2004 JF - Orvosi hetilap JO - Orv Hetil VL - 146 IS - 39 N2 - Cardiovascular disease is a major cause of morbidity and mortality worldwide. During the last decade huge amount of laboratory and clinical evidence proved link between serum lipid concentration and the development of coronary heart disease. The Adult Treatment Panel III of the National Cholesterol Education Program issued an evidence-based set of guidelines on cholesterol management. Since the publication of these guidelines numbers of new clinical trials and experimental results have been published. Recently completed clinical trials have indicated that reduction of low-density lipoprotein cholesterol to goals lower than the previously considered appropriate 2,6 mmol/l, produce further cardiovascular risk reduction in high risk individuals. There is growing evidence of the role of inflammation in the development of atherosclerosis and cardiovascular disease. Numerous studies have demonstrated that elevated C-reactive protein may be an independent cardiovascular risk factor. Statin therapy has produced a greater cardiovascular risk reduction in those patients whose C-reactive protein level was high. Ezetimibe is a new intestinal cholesterol uptake inhibitor, which reduces LDL cholesterol in monotherapy or in combination with statins. Lately a variety of new antilipemic agents are being developed. The present review summarizes some of these new results and their effect on cholesterol lowering therapy. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/16265867/[New_results_in_the_management_of_hypercholesterolemia]_ L2 - http://www.diseaseinfosearch.org/result/3550 DB - PRIME DP - Unbound Medicine ER -