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3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium.
J Ethnopharmacol. 2006 Feb 20; 103(3):461-7.JE

Abstract

A new prenylated salicylic acid derivative, 3-farnesyl-2-hydroxy benzoic acid (1), was isolated from the leaves of Piper multiplinervium C. DC. (Piperaceae). It showed anti-Helicobacter pylori activity (MIC 37.5 microg/ml) and antimicrobial activity at MICs between 2.5 and 5 microg/ml against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Mycobacterium smegmatis, Pseudomonas aeruginosa and Candida albicans. Its structure was elucidated by means of MS, 1H and 13C NMR. The ethnomedical claim of Piper multiplinervium to treat stomach aches by the Kuna Indians of Panama may be justified by anti-Helicobacter pylori activity of its MeOH extract.

Authors+Show Affiliations

Rüegg T
Center for Pharmacognostic Research on Panamanian Flora (CIFLORPAN), College of Pharmacy, University of Panama, Apartado 10767, Panama, Panama.
Calderón AI
No affiliation info available
Queiroz EF
No affiliation info available
Solís PN
No affiliation info available
Marston A
No affiliation info available
Rivas F
No affiliation info available
Ortega-Barría E
No affiliation info available
Hostettmann K
No affiliation info available
Gupta MP
No affiliation info available

MeSH

Anti-Infective AgentsEscherichia coliFarnesolHelicobacter pyloriHydroxybenzoatesMicrobial Sensitivity TestsMolecular StructurePanamaPiperPlant LeavesStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16266794

Citation

Rüegg, T, et al. "3-Farnesyl-2-hydroxybenzoic Acid Is a New anti-Helicobacter Pylori Compound From Piper Multiplinervium." Journal of Ethnopharmacology, vol. 103, no. 3, 2006, pp. 461-7.
Rüegg T, Calderón AI, Queiroz EF, et al. 3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium. J Ethnopharmacol. 2006;103(3):461-7.
Rüegg, T., Calderón, A. I., Queiroz, E. F., Solís, P. N., Marston, A., Rivas, F., Ortega-Barría, E., Hostettmann, K., & Gupta, M. P. (2006). 3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium. Journal of Ethnopharmacology, 103(3), 461-7.
Rüegg T, et al. 3-Farnesyl-2-hydroxybenzoic Acid Is a New anti-Helicobacter Pylori Compound From Piper Multiplinervium. J Ethnopharmacol. 2006 Feb 20;103(3):461-7. PubMed PMID: 16266794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium. AU - Rüegg,T, AU - Calderón,A I, AU - Queiroz,E F, AU - Solís,P N, AU - Marston,A, AU - Rivas,F, AU - Ortega-Barría,E, AU - Hostettmann,K, AU - Gupta,M P, Y1 - 2005/11/02/ PY - 2005/03/01/received PY - 2005/08/25/revised PY - 2005/09/11/accepted PY - 2005/11/4/pubmed PY - 2007/7/31/medline PY - 2005/11/4/entrez SP - 461 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 103 IS - 3 N2 - A new prenylated salicylic acid derivative, 3-farnesyl-2-hydroxy benzoic acid (1), was isolated from the leaves of Piper multiplinervium C. DC. (Piperaceae). It showed anti-Helicobacter pylori activity (MIC 37.5 microg/ml) and antimicrobial activity at MICs between 2.5 and 5 microg/ml against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Mycobacterium smegmatis, Pseudomonas aeruginosa and Candida albicans. Its structure was elucidated by means of MS, 1H and 13C NMR. The ethnomedical claim of Piper multiplinervium to treat stomach aches by the Kuna Indians of Panama may be justified by anti-Helicobacter pylori activity of its MeOH extract. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16266794/3_Farnesyl_2_hydroxybenzoic_acid_is_a_new_anti_Helicobacter_pylori_compound_from_Piper_multiplinervium_ DB - PRIME DP - Unbound Medicine ER -