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Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations.
Proc Am Thorac Soc. 2005; 2(4):361-6; discussion 371-2.PA

Abstract

Exacerbations of chronic obstructive pulmonary disease (COPD) are a major cause of morbidity, mortality, and rising health care costs. In addition, they are associated with an accelerated loss of lung function and thus have a direct effect on disease progression. There are few studies examining the cellular and molecular mechanisms of COPD exacerbations. Exacerbations are linked to increased airway inflammation and oxidative stress, but many questions remain unanswered regarding the key inflammatory cells and mediators. Current therapies for COPD exacerbations are of limited effectiveness, and a better understanding of the inflammatory events at exacerbation is required to devise new therapeutic agents. The development of experimental models of exacerbation-for example, the use of experimental rhinovirus infection in humans with COPD-would greatly facilitate studies of exacerbations.

Authors+Show Affiliations

Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16267363

Citation

Mallia, Patrick, and Sebastian L. Johnston. "Mechanisms and Experimental Models of Chronic Obstructive Pulmonary Disease Exacerbations." Proceedings of the American Thoracic Society, vol. 2, no. 4, 2005, pp. 361-6; discussion 371-2.
Mallia P, Johnston SL. Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations. Proc Am Thorac Soc. 2005;2(4):361-6; discussion 371-2.
Mallia, P., & Johnston, S. L. (2005). Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations. Proceedings of the American Thoracic Society, 2(4), 361-6; discussion 371-2.
Mallia P, Johnston SL. Mechanisms and Experimental Models of Chronic Obstructive Pulmonary Disease Exacerbations. Proc Am Thorac Soc. 2005;2(4):361-6; discussion 371-2. PubMed PMID: 16267363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations. AU - Mallia,Patrick, AU - Johnston,Sebastian L, PY - 2005/11/4/pubmed PY - 2006/2/16/medline PY - 2005/11/4/entrez SP - 361-6; discussion 371-2 JF - Proceedings of the American Thoracic Society JO - Proc Am Thorac Soc VL - 2 IS - 4 N2 - Exacerbations of chronic obstructive pulmonary disease (COPD) are a major cause of morbidity, mortality, and rising health care costs. In addition, they are associated with an accelerated loss of lung function and thus have a direct effect on disease progression. There are few studies examining the cellular and molecular mechanisms of COPD exacerbations. Exacerbations are linked to increased airway inflammation and oxidative stress, but many questions remain unanswered regarding the key inflammatory cells and mediators. Current therapies for COPD exacerbations are of limited effectiveness, and a better understanding of the inflammatory events at exacerbation is required to devise new therapeutic agents. The development of experimental models of exacerbation-for example, the use of experimental rhinovirus infection in humans with COPD-would greatly facilitate studies of exacerbations. SN - 1546-3222 UR - https://www.unboundmedicine.com/medline/citation/16267363/Mechanisms_and_experimental_models_of_chronic_obstructive_pulmonary_disease_exacerbations_ L2 - https://ClinicalTrials.gov/search/term=16267363 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -