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Intake of milk fat, reflected in adipose tissue fatty acids and risk of myocardial infarction: a case-control study.
Eur J Clin Nutr 2006; 60(2):236-44EJ

Abstract

OBJECTIVE

To study the association between content of fatty acids from milk fat (14:0, 15:0 and 17:0) in adipose tissue and risk of a first myocardial infarction (MI).

DESIGN AND SUBJECTS

A case-control study with 99 patients and 98 population controls both men and postmenopausal women, age 45-75 year. Adipose tissue fatty acids were determined by gas-liquid chromatography.

RESULTS

The content of 14:0, 14:1, 15:0, 17:0 and 17:1 were all significantly higher in adipose tissue of controls than of the patients. Age and sex adjusted odds ratios (OR) for MI were significantly reduced with increasing quartiles of 14:0, 14:1, 15:0 and 17:1 in adipose tissue, but except for 15:0 (OR = 0.36, 95% CI 0.13-0.99), the trend was no longer significant after further adjustment for waist-to-hip ratio, smoking and family history for coronary heart disease. Correlations between 14:0 and 15:0 in adipose tissue, and waist-to-hip ratio were significantly negative (r = -0.22 for both, P < 0.01).

CONCLUSION

Our study suggests that intake of dairy fat or some other component of dairy products, as reflected by C15:0 as marker in adipose tissue, may protect persons at increased risk from having a first MI, and that the causal effects may rely on other factors than serum cholesterol.

SPONSORSHIP

Throne Holst's foundation for Nutrition Research, Research Council of Norway, The Norwegian Association of Margarine Producers, DeNoFa Fabriker A/S, TINE BA.

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    Authors+Show Affiliations

    Biong AS
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Norway.
    Veierød MB
    No affiliation info available
    Ringstad J
    No affiliation info available
    Thelle DS
    No affiliation info available
    Pedersen JI
    No affiliation info available

    MeSH

    Adipose TissueAge FactorsAgedAnimalsCase-Control StudiesFatty AcidsFemaleHumansMaleMiddle AgedMilkMyocardial InfarctionOdds RatioRisk FactorsSex FactorsWaist-Hip Ratio

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16267503

    Citation

    Biong, A S., et al. "Intake of Milk Fat, Reflected in Adipose Tissue Fatty Acids and Risk of Myocardial Infarction: a Case-control Study." European Journal of Clinical Nutrition, vol. 60, no. 2, 2006, pp. 236-44.
    Biong AS, Veierød MB, Ringstad J, et al. Intake of milk fat, reflected in adipose tissue fatty acids and risk of myocardial infarction: a case-control study. Eur J Clin Nutr. 2006;60(2):236-44.
    Biong, A. S., Veierød, M. B., Ringstad, J., Thelle, D. S., & Pedersen, J. I. (2006). Intake of milk fat, reflected in adipose tissue fatty acids and risk of myocardial infarction: a case-control study. European Journal of Clinical Nutrition, 60(2), pp. 236-44.
    Biong AS, et al. Intake of Milk Fat, Reflected in Adipose Tissue Fatty Acids and Risk of Myocardial Infarction: a Case-control Study. Eur J Clin Nutr. 2006;60(2):236-44. PubMed PMID: 16267503.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of milk fat, reflected in adipose tissue fatty acids and risk of myocardial infarction: a case-control study. AU - Biong,A S, AU - Veierød,M B, AU - Ringstad,J, AU - Thelle,D S, AU - Pedersen,J I, PY - 2005/11/4/pubmed PY - 2006/5/19/medline PY - 2005/11/4/entrez SP - 236 EP - 44 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 2 N2 - OBJECTIVE: To study the association between content of fatty acids from milk fat (14:0, 15:0 and 17:0) in adipose tissue and risk of a first myocardial infarction (MI). DESIGN AND SUBJECTS: A case-control study with 99 patients and 98 population controls both men and postmenopausal women, age 45-75 year. Adipose tissue fatty acids were determined by gas-liquid chromatography. RESULTS: The content of 14:0, 14:1, 15:0, 17:0 and 17:1 were all significantly higher in adipose tissue of controls than of the patients. Age and sex adjusted odds ratios (OR) for MI were significantly reduced with increasing quartiles of 14:0, 14:1, 15:0 and 17:1 in adipose tissue, but except for 15:0 (OR = 0.36, 95% CI 0.13-0.99), the trend was no longer significant after further adjustment for waist-to-hip ratio, smoking and family history for coronary heart disease. Correlations between 14:0 and 15:0 in adipose tissue, and waist-to-hip ratio were significantly negative (r = -0.22 for both, P < 0.01). CONCLUSION: Our study suggests that intake of dairy fat or some other component of dairy products, as reflected by C15:0 as marker in adipose tissue, may protect persons at increased risk from having a first MI, and that the causal effects may rely on other factors than serum cholesterol. SPONSORSHIP: Throne Holst's foundation for Nutrition Research, Research Council of Norway, The Norwegian Association of Margarine Producers, DeNoFa Fabriker A/S, TINE BA. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16267503/Intake_of_milk_fat_reflected_in_adipose_tissue_fatty_acids_and_risk_of_myocardial_infarction:_a_case_control_study_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602307 DB - PRIME DP - Unbound Medicine ER -