TY - JOUR T1 - Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia. AU - Woo,Patrick C Y, AU - Lau,Susanna K P, AU - Tsoi,Hoi-Wah, AU - Huang,Yi, AU - Poon,Rosana W S, AU - Chu,Chung-Ming, AU - Lee,Rodney A, AU - Luk,Wei-Kwang, AU - Wong,Gilman K M, AU - Wong,Beatrice H L, AU - Cheng,Vincent C C, AU - Tang,Bone S F, AU - Wu,Alan K L, AU - Yung,Raymond W H, AU - Chen,Honglin, AU - Guan,Yi, AU - Chan,Kwok-Hung, AU - Yuen,Kwok-Yung, Y1 - 2005/10/20/ PY - 2005/04/07/received PY - 2005/05/30/revised PY - 2005/06/07/accepted PY - 2005/11/4/pubmed PY - 2006/1/20/medline PY - 2005/11/4/entrez SP - 1898 EP - 907 JF - The Journal of infectious diseases JO - J Infect Dis VL - 192 IS - 11 N2 - BACKGROUND: Recently, we described the discovery of a novel group 2 coronavirus, coronavirus HKU1 (CoV-HKU1), from a patient with pneumonia. However, the clinical and molecular epidemiological features of CoV-HKU1-associated pneumonia are unknown. METHODS: Prospectively collected (during a 12-month period) nasopharyngeal aspirates (NPAs) from patients with community-acquired pneumonia from 4 hospitals were subjected to reverse-transcription polymerase chain reaction, for detection of CoV-HKU1. The epidemiological, clinical, and laboratory characteristics of patients with CoV-HKU1-associated pneumonia were analyzed. The pol, spike (S), and nucleocapsid (N) genes were also sequenced. RESULTS: NPAs from 10 (2.4%) of 418 patients with community-acquired pneumonia were found to be positive for CoV-HKU1. All 10 cases occurred in spring and winter. Nine of these patients were adults, and 4 had underlying diseases of the respiratory tract. In the 6 patients from whom serum samples were available, all had a 4-fold change in immunoglobulin (Ig) G titer and/or presence of IgM against CoV-HKU1. The 2 patients who died had significantly lower hemoglobin levels, monocyte counts, albumin levels, and oxygen saturation levels on admission and had more-extensive involvement visible on chest radiographs. Sequence analysis of the pol, S, and N genes revealed 2 genotypes of CoV-HKU1. CONCLUSIONS: CoV-HKU1 accounts for 2.4% of community-acquired pneumonia, with 2 genotypes in the study population. Without performance of diagnostic tests, the illness was clinically indistinguishable from other community-acquired pneumonia illnesses. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/16267760/Clinical_and_molecular_epidemiological_features_of_coronavirus_HKU1_associated_community_acquired_pneumonia_ DB - PRIME DP - Unbound Medicine ER -