Tags

Type your tag names separated by a space and hit enter

Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.
Thromb Haemost 2005; 94(3):510-5TH

Abstract

Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) is an established determinant of homocysteine plasma level (t-Hcys) while its association with coronary artery disease (CAD) seems to be more limited. In contrast, the association of the substitutions A2756G of methionine synthase (MTR), A66G of methionine synthase reductase (MTRR) and C776G of transcobalamin (TCN) to both t-Hcys and CAD needs to be evaluated further. The objective was to evaluate the association of these polymorphisms with t-Hcys and CAD in a French population. We investigated the individual and combined effects of these polymorphisms and of vitamin B12 and folates with t-Hcys in 530 CAD patients and 248 matched healthy controls. t-Hcys was higher in the CAD group than in controls (11.8 vs 10.4 microM, P < 0.0001) and in carriers of MTRRAA and MTHFR 677TT than in those carrying the most frequent allele of both polymorphisms (13.8 vs 11.4 microM, P = 0.0102 and 12.5 vs 11.0 mM, P = 0.0065 respectively). The frequency of MTRR A allele was higher in CAD patients than in controls (0.48 [95% CI: 0.44-0.52] vs 0.38 [95% CI: 0.32-0.44], P = 0.0081) while no difference was observed for MTHFR 677T frequency. In multivariate analysis, t-Hcys > median and MTRRAA genotype were two significant independent predictors of CAD with respective odds ratios of 3.1 (95 % CI: 1.8-5.1, P < 0.0001) and 4.5 (95% CI: 1.5-13.1, P = 0.0051). In conclusion, in contrast to North Europe studies, MTRRAA genotype is a genetic determinant of moderate hyperhomocysteinemia associated with CAD in a French population without vitamin fortification.

Authors+Show Affiliations

INSERM U-724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Vandoeuvre-les-Nancy Cedex, France. rm.rodriguez@chu-nancy.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16268464

Citation

Guéant-Rodriguez, Rosa-Maria, et al. "Association of MTRRA66G Polymorphism (but Not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) With Homocysteine and Coronary Artery Disease in the French Population." Thrombosis and Haemostasis, vol. 94, no. 3, 2005, pp. 510-5.
Guéant-Rodriguez RM, Juilliére Y, Candito M, et al. Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. Thromb Haemost. 2005;94(3):510-5.
Guéant-Rodriguez, R. M., Juilliére, Y., Candito, M., Adjalla, C. E., Gibelin, P., Herbeth, B., ... Gueánt, J. L. (2005). Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. Thrombosis and Haemostasis, 94(3), pp. 510-5.
Guéant-Rodriguez RM, et al. Association of MTRRA66G Polymorphism (but Not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) With Homocysteine and Coronary Artery Disease in the French Population. Thromb Haemost. 2005;94(3):510-5. PubMed PMID: 16268464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. AU - Guéant-Rodriguez,Rosa-Maria, AU - Juilliére,Yves, AU - Candito,Mirande, AU - Adjalla,Charles E, AU - Gibelin,Pierre, AU - Herbeth,Bernard, AU - Van Obberghen,Emmanuel, AU - Gueánt,Jean-Louis, PY - 2005/11/5/pubmed PY - 2006/6/7/medline PY - 2005/11/5/entrez SP - 510 EP - 5 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 94 IS - 3 N2 - Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) is an established determinant of homocysteine plasma level (t-Hcys) while its association with coronary artery disease (CAD) seems to be more limited. In contrast, the association of the substitutions A2756G of methionine synthase (MTR), A66G of methionine synthase reductase (MTRR) and C776G of transcobalamin (TCN) to both t-Hcys and CAD needs to be evaluated further. The objective was to evaluate the association of these polymorphisms with t-Hcys and CAD in a French population. We investigated the individual and combined effects of these polymorphisms and of vitamin B12 and folates with t-Hcys in 530 CAD patients and 248 matched healthy controls. t-Hcys was higher in the CAD group than in controls (11.8 vs 10.4 microM, P < 0.0001) and in carriers of MTRRAA and MTHFR 677TT than in those carrying the most frequent allele of both polymorphisms (13.8 vs 11.4 microM, P = 0.0102 and 12.5 vs 11.0 mM, P = 0.0065 respectively). The frequency of MTRR A allele was higher in CAD patients than in controls (0.48 [95% CI: 0.44-0.52] vs 0.38 [95% CI: 0.32-0.44], P = 0.0081) while no difference was observed for MTHFR 677T frequency. In multivariate analysis, t-Hcys > median and MTRRAA genotype were two significant independent predictors of CAD with respective odds ratios of 3.1 (95 % CI: 1.8-5.1, P < 0.0001) and 4.5 (95% CI: 1.5-13.1, P = 0.0051). In conclusion, in contrast to North Europe studies, MTRRAA genotype is a genetic determinant of moderate hyperhomocysteinemia associated with CAD in a French population without vitamin fortification. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/16268464/Association_of_MTRRA66G_polymorphism__but_not_of_MTHFR_C677T_and_A1298C_MTRA2756G_TCN_C776G__with_homocysteine_and_coronary_artery_disease_in_the_French_population_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1160/TH05-04-0262 DB - PRIME DP - Unbound Medicine ER -