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Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity.
Clin Endocrinol (Oxf). 2005 Nov; 63(5):594-8.CE

Abstract

OBJECTIVE

We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients.

PATIENTS AND MEASUREMENTS

The study subjects comprised 49 newly diagnosed diabetic patients and 72 age- and sex-matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and brachial-ankle pulse wave velocity (baPWV) were measured.

RESULTS

Serum OPG levels (6.1 +/- 1.4 vs. 5.4 +/- 1.3 pmol/l, P = 0.011) and baPWV (1562 +/- 354 vs. 1399 +/- 257 cm/s, P = 0.004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0.20, P = 0.035), FBG (r = 0.30, P = 0.002), right baPWV (r = 0.22, P = 0.021), left baPWV (r = 0.26, P = 0.006), homeostasis model assessment insulin resistance (HOMA-IR) (r = 0.19, P = 0.045), IL-6 (r = 0.32, P = 0.001) and hsCRP (r = 0.21, P = 0.027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL-6, systolic blood pressure, triglyceride and hsCRP (R(2) = 0.299).

CONCLUSIONS

In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.

Authors+Show Affiliations

Department of Family Medicine, Korea University College of Medicine, Seoul.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16268814

Citation

Kim, S M., et al. "Serum Osteoprotegerin Levels Are Associated With Inflammation and Pulse Wave Velocity." Clinical Endocrinology, vol. 63, no. 5, 2005, pp. 594-8.
Kim SM, Lee J, Ryu OH, et al. Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity. Clin Endocrinol (Oxf). 2005;63(5):594-8.
Kim, S. M., Lee, J., Ryu, O. H., Lee, K. W., Kim, H. Y., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M. (2005). Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity. Clinical Endocrinology, 63(5), 594-8.
Kim SM, et al. Serum Osteoprotegerin Levels Are Associated With Inflammation and Pulse Wave Velocity. Clin Endocrinol (Oxf). 2005;63(5):594-8. PubMed PMID: 16268814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity. AU - Kim,S M, AU - Lee,J, AU - Ryu,O H, AU - Lee,K W, AU - Kim,H Y, AU - Seo,J A, AU - Kim,S G, AU - Kim,N H, AU - Baik,S H, AU - Choi,D S, AU - Choi,K M, PY - 2005/11/5/pubmed PY - 2006/2/10/medline PY - 2005/11/5/entrez SP - 594 EP - 8 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 63 IS - 5 N2 - OBJECTIVE: We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients. PATIENTS AND MEASUREMENTS: The study subjects comprised 49 newly diagnosed diabetic patients and 72 age- and sex-matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and brachial-ankle pulse wave velocity (baPWV) were measured. RESULTS: Serum OPG levels (6.1 +/- 1.4 vs. 5.4 +/- 1.3 pmol/l, P = 0.011) and baPWV (1562 +/- 354 vs. 1399 +/- 257 cm/s, P = 0.004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0.20, P = 0.035), FBG (r = 0.30, P = 0.002), right baPWV (r = 0.22, P = 0.021), left baPWV (r = 0.26, P = 0.006), homeostasis model assessment insulin resistance (HOMA-IR) (r = 0.19, P = 0.045), IL-6 (r = 0.32, P = 0.001) and hsCRP (r = 0.21, P = 0.027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL-6, systolic blood pressure, triglyceride and hsCRP (R(2) = 0.299). CONCLUSIONS: In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/16268814/Serum_osteoprotegerin_levels_are_associated_with_inflammation_and_pulse_wave_velocity_ L2 - https://doi.org/10.1111/j.1365-2265.2005.02390.x DB - PRIME DP - Unbound Medicine ER -