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Carotid intima-media thickness is slightly increased over time in HIV-1-infected patients.
HIV Med 2005; 6(6):380-7HM

Abstract

OBJECTIVES

HIV-infected patients are at risk of atherosclerosis and cardiovascular diseases. In a 12-month follow-up study, we aimed to investigate changes in carotid intima-media thickness (IMT), a surrogate marker of atherosclerosis, and its determinants in HIV-1-infected patients.

METHODS

Our multicentre prospective longitudinal cohort study included 346 HIV-infected patients, for each of whom two IMT measurements were taken by B-mode ultrasonography at baseline (M0) and 1 year later (M12).

RESULTS

We observed a significant but moderate increase in the common carotid artery (CCA) median IMT, from 0.54 to 0.56 mm (P<10(-4)), i.e. an increase of 0.020 mm (95% confidence interval 0.012-0.029). There was a significant association between cross-sectional CCA IMT measures at M12 and conventional cardiovascular risk factors (higher CCA IMT with older age, P<10(-4); male gender, P=0.02; tobacco consumption, P=0.05), as well as higher CD4 cell count at M12 (>median 455 cells/microL, P=0.01). Only CD4 cell count at M0 was strongly and positively associated with the variation in IMT between M0 and M12 (P=4 x 10(-3)). IMT progression was +0.0020 mm for the lowest quartile of CD4 cell count distribution at M0, i.e. 3-253 cells/microL, +0.010 mm for 253-402 cells/microL, +0.043 mm for 402-590 cells/microL, and +0.028 mm for 590-2270 cells/microL. No association was found with type or duration of antiretroviral exposure.

CONCLUSIONS

Conventional cardiovascular risk factors are major determinants of IMT evolution. The link between immunological status and carotid IMT requires further study.

Authors+Show Affiliations

Internal Medicine and Infectious Diseases, University Hospital of Bordeaux, France. patrick.mercie@chu-bordeaux.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16268819

Citation

Mercié, P, et al. "Carotid Intima-media Thickness Is Slightly Increased Over Time in HIV-1-infected Patients." HIV Medicine, vol. 6, no. 6, 2005, pp. 380-7.
Mercié P, Thiébaut R, Aurillac-Lavignolle V, et al. Carotid intima-media thickness is slightly increased over time in HIV-1-infected patients. HIV Med. 2005;6(6):380-7.
Mercié, P., Thiébaut, R., Aurillac-Lavignolle, V., Pellegrin, J. L., Yvorra-Vives, M. C., Cipriano, C., ... Dabis, F. (2005). Carotid intima-media thickness is slightly increased over time in HIV-1-infected patients. HIV Medicine, 6(6), pp. 380-7.
Mercié P, et al. Carotid Intima-media Thickness Is Slightly Increased Over Time in HIV-1-infected Patients. HIV Med. 2005;6(6):380-7. PubMed PMID: 16268819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotid intima-media thickness is slightly increased over time in HIV-1-infected patients. AU - Mercié,P, AU - Thiébaut,R, AU - Aurillac-Lavignolle,V, AU - Pellegrin,J L, AU - Yvorra-Vives,M C, AU - Cipriano,C, AU - Neau,D, AU - Morlat,P, AU - Ragnaud,J M, AU - Dupon,M, AU - Bonnet,F, AU - Lawson-Ayayi,S, AU - Malvy,D, AU - Roudaut,R, AU - Dabis,F, AU - ,, PY - 2005/11/5/pubmed PY - 2006/6/30/medline PY - 2005/11/5/entrez SP - 380 EP - 7 JF - HIV medicine JO - HIV Med. VL - 6 IS - 6 N2 - OBJECTIVES: HIV-infected patients are at risk of atherosclerosis and cardiovascular diseases. In a 12-month follow-up study, we aimed to investigate changes in carotid intima-media thickness (IMT), a surrogate marker of atherosclerosis, and its determinants in HIV-1-infected patients. METHODS: Our multicentre prospective longitudinal cohort study included 346 HIV-infected patients, for each of whom two IMT measurements were taken by B-mode ultrasonography at baseline (M0) and 1 year later (M12). RESULTS: We observed a significant but moderate increase in the common carotid artery (CCA) median IMT, from 0.54 to 0.56 mm (P<10(-4)), i.e. an increase of 0.020 mm (95% confidence interval 0.012-0.029). There was a significant association between cross-sectional CCA IMT measures at M12 and conventional cardiovascular risk factors (higher CCA IMT with older age, P<10(-4); male gender, P=0.02; tobacco consumption, P=0.05), as well as higher CD4 cell count at M12 (>median 455 cells/microL, P=0.01). Only CD4 cell count at M0 was strongly and positively associated with the variation in IMT between M0 and M12 (P=4 x 10(-3)). IMT progression was +0.0020 mm for the lowest quartile of CD4 cell count distribution at M0, i.e. 3-253 cells/microL, +0.010 mm for 253-402 cells/microL, +0.043 mm for 402-590 cells/microL, and +0.028 mm for 590-2270 cells/microL. No association was found with type or duration of antiretroviral exposure. CONCLUSIONS: Conventional cardiovascular risk factors are major determinants of IMT evolution. The link between immunological status and carotid IMT requires further study. SN - 1464-2662 UR - https://www.unboundmedicine.com/medline/citation/16268819/Carotid_intima_media_thickness_is_slightly_increased_over_time_in_HIV_1_infected_patients_ L2 - https://doi.org/10.1111/j.1468-1293.2005.00324.x DB - PRIME DP - Unbound Medicine ER -