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Physical activity, obesity, energy intake, and the risk of non-Hodgkin's lymphoma: a population-based case-control study.

Abstract

The authors conducted a population-based case-control study of 1,030 cases with histologically confirmed, incident non-Hodgkin's lymphoma (NHL) and 3,106 controls to assess the impact of recreational physical activity, obesity, and energy intake on NHL risk in Canada from 1994 to 1997. Compared with those for subjects in the lowest quartiles of total recreational physical activity, multivariable-adjusted odds ratios for subjects in the highest quartile were 0.79 (95% confidence interval (CI): 0.59, 1.05) for men and 0.59 (95% CI: 0.42, 0.81) for women. Obesity (body mass index > or = 30 kg/m2) was associated with odds ratios of 1.59 (95% CI: 1.18, 2.12) for men and 1.36 (95% CI: 1.00, 1.84) for women. For men and women with a lifetime maximum body mass index of > or = 30 kg/m2, respective odds ratios were 1.55 (95% CI: 1.16, 2.06) and 1.10 (95% CI: 0.83, 1.46). For men and women in the highest quartiles of calorie intake, respective odds ratios were 1.95 (95% CI: 1.45, 2.62) and 1.13 (95% CI: 0.84, 1.52). Some differences were found between histologic subtypes of NHL for these associations. This study suggests that recreational physical activity decreases NHL risk, while obesity and excess calorie intake increase it. More studies are needed to confirm these results, especially the differences between histologic subtypes.

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  • Authors+Show Affiliations

    ,

    Surveillance and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada.

    , ,

    Source

    American journal of epidemiology 162:12 2005 Dec 15 pg 1162-73

    MeSH

    Adult
    Aged
    Canada
    Case-Control Studies
    Energy Intake
    Female
    Humans
    Incidence
    Logistic Models
    Lymphoma, Non-Hodgkin
    Male
    Middle Aged
    Motor Activity
    Obesity
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16269580

    Citation

    Pan, Sai Yi, et al. "Physical Activity, Obesity, Energy Intake, and the Risk of non-Hodgkin's Lymphoma: a Population-based Case-control Study." American Journal of Epidemiology, vol. 162, no. 12, 2005, pp. 1162-73.
    Pan SY, Mao Y, Ugnat AM, et al. Physical activity, obesity, energy intake, and the risk of non-Hodgkin's lymphoma: a population-based case-control study. Am J Epidemiol. 2005;162(12):1162-73.
    Pan, S. Y., Mao, Y., & Ugnat, A. M. (2005). Physical activity, obesity, energy intake, and the risk of non-Hodgkin's lymphoma: a population-based case-control study. American Journal of Epidemiology, 162(12), pp. 1162-73.
    Pan SY, et al. Physical Activity, Obesity, Energy Intake, and the Risk of non-Hodgkin's Lymphoma: a Population-based Case-control Study. Am J Epidemiol. 2005 Dec 15;162(12):1162-73. PubMed PMID: 16269580.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Physical activity, obesity, energy intake, and the risk of non-Hodgkin's lymphoma: a population-based case-control study. AU - Pan,Sai Yi, AU - Mao,Yang, AU - Ugnat,Anne-Marie, AU - ,, Y1 - 2005/11/03/ PY - 2005/11/5/pubmed PY - 2006/2/17/medline PY - 2005/11/5/entrez SP - 1162 EP - 73 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 162 IS - 12 N2 - The authors conducted a population-based case-control study of 1,030 cases with histologically confirmed, incident non-Hodgkin's lymphoma (NHL) and 3,106 controls to assess the impact of recreational physical activity, obesity, and energy intake on NHL risk in Canada from 1994 to 1997. Compared with those for subjects in the lowest quartiles of total recreational physical activity, multivariable-adjusted odds ratios for subjects in the highest quartile were 0.79 (95% confidence interval (CI): 0.59, 1.05) for men and 0.59 (95% CI: 0.42, 0.81) for women. Obesity (body mass index > or = 30 kg/m2) was associated with odds ratios of 1.59 (95% CI: 1.18, 2.12) for men and 1.36 (95% CI: 1.00, 1.84) for women. For men and women with a lifetime maximum body mass index of > or = 30 kg/m2, respective odds ratios were 1.55 (95% CI: 1.16, 2.06) and 1.10 (95% CI: 0.83, 1.46). For men and women in the highest quartiles of calorie intake, respective odds ratios were 1.95 (95% CI: 1.45, 2.62) and 1.13 (95% CI: 0.84, 1.52). Some differences were found between histologic subtypes of NHL for these associations. This study suggests that recreational physical activity decreases NHL risk, while obesity and excess calorie intake increase it. More studies are needed to confirm these results, especially the differences between histologic subtypes. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16269580/Physical_activity_obesity_energy_intake_and_the_risk_of_non_Hodgkin's_lymphoma:_a_population_based_case_control_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi342 DB - PRIME DP - Unbound Medicine ER -