Tags

Type your tag names separated by a space and hit enter

Serum tissue inhibitors of metalloproteinases 1 (TIMP-1) and carotid atherosclerosis and aortic arterial stiffness.
J Hypertens. 2005 Dec; 23(12):2263-8.JH

Abstract

BACKGROUND

The results of experimental studies have suggested that matrix metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), are involved in vascular remodeling. In a population-based study, we report the relationships of serum TIMP-1 with carotid intima-media thickness, carotid plaques and aortic arterial stiffness.

METHODS

Free health examinations were performed on 238 men free of coronary heart diseases (aged 56.5 +/- 10.4 years, 57.1% were hypertensive). Carotid-femoral pulse-wave velocity (PWV) was used to assess aortic stiffness. Carotid ultrasound examination included measurements (at sites free of plaques) of intima-media thickness (IMT) at the common carotid arteries (CCA) and assessment of atherosclerotic plaques in the extracranial carotid arteries.

RESULTS

The percentage of subjects with plaques was lower in subjects with low TIMP-1 values (P for trend = 0.0001). In multivariate analysis adjusted for age, body mass index, smoking habits, total cholesterol, triglycerides, C-reactive protein, heart rate, diabetes and systolic blood pressure, the odds ratio of carotid plaques in subjects with high values of TIMP-1 (tertile 3) compared to those with low values (tertile 1) was 2.89 (95% confidence interval 1.12-7.47, P < 0.01). TIMP-1 was positively associated with CCA-IMT and PWV in univariate analysis. However, the associations disappeared once age and systolic blood pressure were taken into account in the multivariate analysis.

CONCLUSION

This study shows that there is a differential association of TIMP-1 with PWV, CCA-IMT and carotid plaques. Our results suggest that TIMP-1 might be involved in plaque formation.

Authors+Show Affiliations

National Institute of Health and Medical Research (INSERM), Unit 508, Lille, France. mahmoud.zureik@pasteur-lille.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16269968

Citation

Zureik, Mahmoud, et al. "Serum Tissue Inhibitors of Metalloproteinases 1 (TIMP-1) and Carotid Atherosclerosis and Aortic Arterial Stiffness." Journal of Hypertension, vol. 23, no. 12, 2005, pp. 2263-8.
Zureik M, Beaudeux JL, Courbon D, et al. Serum tissue inhibitors of metalloproteinases 1 (TIMP-1) and carotid atherosclerosis and aortic arterial stiffness. J Hypertens. 2005;23(12):2263-8.
Zureik, M., Beaudeux, J. L., Courbon, D., Bénétos, A., & Ducimetière, P. (2005). Serum tissue inhibitors of metalloproteinases 1 (TIMP-1) and carotid atherosclerosis and aortic arterial stiffness. Journal of Hypertension, 23(12), 2263-8.
Zureik M, et al. Serum Tissue Inhibitors of Metalloproteinases 1 (TIMP-1) and Carotid Atherosclerosis and Aortic Arterial Stiffness. J Hypertens. 2005;23(12):2263-8. PubMed PMID: 16269968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum tissue inhibitors of metalloproteinases 1 (TIMP-1) and carotid atherosclerosis and aortic arterial stiffness. AU - Zureik,Mahmoud, AU - Beaudeux,Jean-Louis, AU - Courbon,Dominique, AU - Bénétos,Athanase, AU - Ducimetière,Pierre, PY - 2005/11/5/pubmed PY - 2006/3/3/medline PY - 2005/11/5/entrez SP - 2263 EP - 8 JF - Journal of hypertension JO - J. Hypertens. VL - 23 IS - 12 N2 - BACKGROUND: The results of experimental studies have suggested that matrix metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), are involved in vascular remodeling. In a population-based study, we report the relationships of serum TIMP-1 with carotid intima-media thickness, carotid plaques and aortic arterial stiffness. METHODS: Free health examinations were performed on 238 men free of coronary heart diseases (aged 56.5 +/- 10.4 years, 57.1% were hypertensive). Carotid-femoral pulse-wave velocity (PWV) was used to assess aortic stiffness. Carotid ultrasound examination included measurements (at sites free of plaques) of intima-media thickness (IMT) at the common carotid arteries (CCA) and assessment of atherosclerotic plaques in the extracranial carotid arteries. RESULTS: The percentage of subjects with plaques was lower in subjects with low TIMP-1 values (P for trend = 0.0001). In multivariate analysis adjusted for age, body mass index, smoking habits, total cholesterol, triglycerides, C-reactive protein, heart rate, diabetes and systolic blood pressure, the odds ratio of carotid plaques in subjects with high values of TIMP-1 (tertile 3) compared to those with low values (tertile 1) was 2.89 (95% confidence interval 1.12-7.47, P < 0.01). TIMP-1 was positively associated with CCA-IMT and PWV in univariate analysis. However, the associations disappeared once age and systolic blood pressure were taken into account in the multivariate analysis. CONCLUSION: This study shows that there is a differential association of TIMP-1 with PWV, CCA-IMT and carotid plaques. Our results suggest that TIMP-1 might be involved in plaque formation. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/16269968/Serum_tissue_inhibitors_of_metalloproteinases_1__TIMP_1__and_carotid_atherosclerosis_and_aortic_arterial_stiffness_ L2 - http://Insights.ovid.com/pubmed?pmid=16269968 DB - PRIME DP - Unbound Medicine ER -