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Social integration and concentrations of C-reactive protein among US adults.
Ann Epidemiol. 2006 Feb; 16(2):78-84.AE

Abstract

PURPOSE

This study tests whether social integration is associated with C-reactive protein (CRP) level, a biologic risk factor for cardiovascular disease.

METHODS

Using data from 14,818 participants aged>or=20 years from the Third National Health and Nutrition Examination Survey (1988 to 1994), we created a social network index using marital status; number of contacts with family, friends, and neighbors; frequency of religious service attendance; and participation in voluntary organizations. Serum CRP concentration was measured by means of latex-enhanced nephelometry, a low-sensitivity assay, and dichotomized into 3 mg/L or less and greater than 3 mg/L.

RESULTS

After adjustment for multiple potential confounders, men aged>or=60 years with the fewest ties were more likely to have an elevated CRP concentration than men with the most ties (odds ratio=1.80; 95% confidence interval, 1.11-2.92). This occurred in a dose-response manner, with each decrease in number of ties associated with an increase in the proportion of men with elevated CRP levels. The association between social networks and CRP level after multivariate adjustment was not significant in women or younger men.

CONCLUSION

In this nationally representative cohort, CRP level was associated with social integration in older men, but not women or younger men. There may be sex- and age-related differences in biologic processes influenced by social integration.

Authors+Show Affiliations

Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. eford@cdc.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16271297

Citation

Ford, Earl S., et al. "Social Integration and Concentrations of C-reactive Protein Among US Adults." Annals of Epidemiology, vol. 16, no. 2, 2006, pp. 78-84.
Ford ES, Loucks EB, Berkman LF. Social integration and concentrations of C-reactive protein among US adults. Ann Epidemiol. 2006;16(2):78-84.
Ford, E. S., Loucks, E. B., & Berkman, L. F. (2006). Social integration and concentrations of C-reactive protein among US adults. Annals of Epidemiology, 16(2), 78-84.
Ford ES, Loucks EB, Berkman LF. Social Integration and Concentrations of C-reactive Protein Among US Adults. Ann Epidemiol. 2006;16(2):78-84. PubMed PMID: 16271297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Social integration and concentrations of C-reactive protein among US adults. AU - Ford,Earl S, AU - Loucks,Eric B, AU - Berkman,Lisa F, Y1 - 2005/11/02/ PY - 2005/04/22/received PY - 2005/07/08/revised PY - 2005/08/09/accepted PY - 2005/11/8/pubmed PY - 2007/7/4/medline PY - 2005/11/8/entrez SP - 78 EP - 84 JF - Annals of epidemiology JO - Ann Epidemiol VL - 16 IS - 2 N2 - PURPOSE: This study tests whether social integration is associated with C-reactive protein (CRP) level, a biologic risk factor for cardiovascular disease. METHODS: Using data from 14,818 participants aged>or=20 years from the Third National Health and Nutrition Examination Survey (1988 to 1994), we created a social network index using marital status; number of contacts with family, friends, and neighbors; frequency of religious service attendance; and participation in voluntary organizations. Serum CRP concentration was measured by means of latex-enhanced nephelometry, a low-sensitivity assay, and dichotomized into 3 mg/L or less and greater than 3 mg/L. RESULTS: After adjustment for multiple potential confounders, men aged>or=60 years with the fewest ties were more likely to have an elevated CRP concentration than men with the most ties (odds ratio=1.80; 95% confidence interval, 1.11-2.92). This occurred in a dose-response manner, with each decrease in number of ties associated with an increase in the proportion of men with elevated CRP levels. The association between social networks and CRP level after multivariate adjustment was not significant in women or younger men. CONCLUSION: In this nationally representative cohort, CRP level was associated with social integration in older men, but not women or younger men. There may be sex- and age-related differences in biologic processes influenced by social integration. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/16271297/Social_integration_and_concentrations_of_C_reactive_protein_among_US_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(05)00316-9 DB - PRIME DP - Unbound Medicine ER -