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Gender differences in response to lorazepam in a human drug discrimination study.
J Psychopharmacol. 2005 Nov; 19(6):614-9.JP

Abstract

Gender differences in the discriminative stimulus properties of drugs of abuse have sometimes been reported, although we have previously found no differences in subjective or discriminative responses in human subjects acquiring an alcohol discrimination. The aim of the present work was to determine if there were gender differences in the effects of lorazepam, a benzodiazepine-receptor agonist which substituted for the alcohol stimulus in trained social drinkers. Volunteers who had already acquired an alcohol (0.2g/kg) placebo discrimination were administered (double-blind) either placebo (nine females, nine males) or lorazepam 2mg (six females, six males). They then sampled a series of five drinks and rated each one for likeness to the training stimulus (the generalization response). In addition they completed rating scales for subjective effects and the Digit Symbol Substitution Test (DSST). Lorazepam substituted for the alcohol stimulus equally in both sexes and increased associated scores for lightheadedness. Females however, showed a much greater DSST performance impairment following lorazepam, compared with males. This effect was independent of body weight differences and sedation. These results are discussed in the light of current knowledge of gender differences in response to drugs of abuse and suggest that the stimulus and cognitive effects of benzodiazepine-receptor agonists are modulated by different brain mechanisms.

Authors+Show Affiliations

Department of Pharmacology, University of Brighton, School of Pharmacy and Biomolecular Sciences, Moulsecoomb, Brighton BN2 2GJ, UK. anne.jackson@brighton.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16272183

Citation

Jackson, Anne, et al. "Gender Differences in Response to Lorazepam in a Human Drug Discrimination Study." Journal of Psychopharmacology (Oxford, England), vol. 19, no. 6, 2005, pp. 614-9.
Jackson A, Stephens D, Duka T. Gender differences in response to lorazepam in a human drug discrimination study. J Psychopharmacol (Oxford). 2005;19(6):614-9.
Jackson, A., Stephens, D., & Duka, T. (2005). Gender differences in response to lorazepam in a human drug discrimination study. Journal of Psychopharmacology (Oxford, England), 19(6), 614-9.
Jackson A, Stephens D, Duka T. Gender Differences in Response to Lorazepam in a Human Drug Discrimination Study. J Psychopharmacol (Oxford). 2005;19(6):614-9. PubMed PMID: 16272183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender differences in response to lorazepam in a human drug discrimination study. AU - Jackson,Anne, AU - Stephens,David, AU - Duka,Theodora, PY - 2005/11/8/pubmed PY - 2006/2/10/medline PY - 2005/11/8/entrez SP - 614 EP - 9 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 19 IS - 6 N2 - Gender differences in the discriminative stimulus properties of drugs of abuse have sometimes been reported, although we have previously found no differences in subjective or discriminative responses in human subjects acquiring an alcohol discrimination. The aim of the present work was to determine if there were gender differences in the effects of lorazepam, a benzodiazepine-receptor agonist which substituted for the alcohol stimulus in trained social drinkers. Volunteers who had already acquired an alcohol (0.2g/kg) placebo discrimination were administered (double-blind) either placebo (nine females, nine males) or lorazepam 2mg (six females, six males). They then sampled a series of five drinks and rated each one for likeness to the training stimulus (the generalization response). In addition they completed rating scales for subjective effects and the Digit Symbol Substitution Test (DSST). Lorazepam substituted for the alcohol stimulus equally in both sexes and increased associated scores for lightheadedness. Females however, showed a much greater DSST performance impairment following lorazepam, compared with males. This effect was independent of body weight differences and sedation. These results are discussed in the light of current knowledge of gender differences in response to drugs of abuse and suggest that the stimulus and cognitive effects of benzodiazepine-receptor agonists are modulated by different brain mechanisms. SN - 0269-8811 UR - https://www.unboundmedicine.com/medline/citation/16272183/Gender_differences_in_response_to_lorazepam_in_a_human_drug_discrimination_study_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881105056659?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -