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Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin.
Biol Pharm Bull. 2005 Nov; 28(11):2106-10.BP

Abstract

The pancreatic lipase inhibitors were isolated from the fructus of Gardenia jasminoides ELLIS, and their antihyperlipidemic activities were measured. Gardeniae fructus (GF) water extract inhibited pancreatic lipase activity. Crocetin and crocin were isolated from GF water extract as inhibitors of pancreatic lipase with an IC50 value of 2.1 and 2.6 mg/ml (triolein as a substrate). Crocin and crocetin significantly inhibited the increase of serum TG level in corn oil feeding-induced triglyceridemic mice, as well as that of serum triglyceride and total and LDL cholesterol levels in Triton WR-1339-induced hyperlipidemic mice. These compounds also showed hypolipidemic activity in hyperlipidemic mice induced by high cholesterol, high fat or high carbohydrate diets for 5 weeks. The results suggest that the hypolipidemic activity of GF and its component crocin may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, crocetin, can improve hyperlipidemia.

Authors+Show Affiliations

College of Pharmacy, Kyung Hee University, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16272698

Citation

Lee, In-Ah, et al. "Antihyperlipidemic Effect of Crocin Isolated From the Fructus of Gardenia Jasminoides and Its Metabolite Crocetin." Biological & Pharmaceutical Bulletin, vol. 28, no. 11, 2005, pp. 2106-10.
Lee IA, Lee JH, Baek NI, et al. Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin. Biol Pharm Bull. 2005;28(11):2106-10.
Lee, I. A., Lee, J. H., Baek, N. I., & Kim, D. H. (2005). Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin. Biological & Pharmaceutical Bulletin, 28(11), 2106-10.
Lee IA, et al. Antihyperlipidemic Effect of Crocin Isolated From the Fructus of Gardenia Jasminoides and Its Metabolite Crocetin. Biol Pharm Bull. 2005;28(11):2106-10. PubMed PMID: 16272698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin. AU - Lee,In-Ah, AU - Lee,Jin Hee, AU - Baek,Nam-In, AU - Kim,Dong-Hyun, PY - 2005/11/8/pubmed PY - 2005/12/22/medline PY - 2005/11/8/entrez SP - 2106 EP - 10 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 28 IS - 11 N2 - The pancreatic lipase inhibitors were isolated from the fructus of Gardenia jasminoides ELLIS, and their antihyperlipidemic activities were measured. Gardeniae fructus (GF) water extract inhibited pancreatic lipase activity. Crocetin and crocin were isolated from GF water extract as inhibitors of pancreatic lipase with an IC50 value of 2.1 and 2.6 mg/ml (triolein as a substrate). Crocin and crocetin significantly inhibited the increase of serum TG level in corn oil feeding-induced triglyceridemic mice, as well as that of serum triglyceride and total and LDL cholesterol levels in Triton WR-1339-induced hyperlipidemic mice. These compounds also showed hypolipidemic activity in hyperlipidemic mice induced by high cholesterol, high fat or high carbohydrate diets for 5 weeks. The results suggest that the hypolipidemic activity of GF and its component crocin may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, crocetin, can improve hyperlipidemia. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/16272698/Antihyperlipidemic_effect_of_crocin_isolated_from_the_fructus_of_Gardenia_jasminoides_and_its_metabolite_Crocetin_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/28.2106?from=PubMed DB - PRIME DP - Unbound Medicine ER -