Tags

Type your tag names separated by a space and hit enter

A hind limb tourniquet induces interleukin-6 expression in a rat dorsal root ganglion.
Neuroreport. 2005 Nov 28; 16(17):1889-92.N

Abstract

We investigated the mRNA levels of interleukin-6-related genes in a rat dorsal root ganglion after application of a tourniquet to a hind limb in order to identify the molecules that are induced immediately after peripheral nerve injury at the early stage. Induction of interleukin-6 and upregulation of glycoprotein 130 mRNA expressions were observed in the ipsilateral dorsal root ganglion at 4 h after tourniquet application. Interleukin-6 protein was detected in small-sized and medium-sized dorsal root ganglion cells by immunohistochemical analysis. The induction of interleukin-6 expression is likely to play a role in the protection of injured neurons perhaps related to growth of their axons. Glycoprotein 130 might also account for the inhibitory effects following nerve injury.

Authors+Show Affiliations

Department of Legal Medicine, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima, Japan. sumiko@fmu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16272873

Citation

Abe, Sumiko, et al. "A Hind Limb Tourniquet Induces Interleukin-6 Expression in a Rat Dorsal Root Ganglion." Neuroreport, vol. 16, no. 17, 2005, pp. 1889-92.
Abe S, Mizusawa I, Suto M, et al. A hind limb tourniquet induces interleukin-6 expression in a rat dorsal root ganglion. Neuroreport. 2005;16(17):1889-92.
Abe, S., Mizusawa, I., Suto, M., Kato, N., Yabashi, A., Honda, T., & Hiraiwa, K. (2005). A hind limb tourniquet induces interleukin-6 expression in a rat dorsal root ganglion. Neuroreport, 16(17), 1889-92.
Abe S, et al. A Hind Limb Tourniquet Induces Interleukin-6 Expression in a Rat Dorsal Root Ganglion. Neuroreport. 2005 Nov 28;16(17):1889-92. PubMed PMID: 16272873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A hind limb tourniquet induces interleukin-6 expression in a rat dorsal root ganglion. AU - Abe,Sumiko, AU - Mizusawa,Ikubumi, AU - Suto,Miwako, AU - Kato,Naho, AU - Yabashi,Atsuko, AU - Honda,Takashi, AU - Hiraiwa,Kouichi, PY - 2005/11/8/pubmed PY - 2006/1/18/medline PY - 2005/11/8/entrez SP - 1889 EP - 92 JF - Neuroreport JO - Neuroreport VL - 16 IS - 17 N2 - We investigated the mRNA levels of interleukin-6-related genes in a rat dorsal root ganglion after application of a tourniquet to a hind limb in order to identify the molecules that are induced immediately after peripheral nerve injury at the early stage. Induction of interleukin-6 and upregulation of glycoprotein 130 mRNA expressions were observed in the ipsilateral dorsal root ganglion at 4 h after tourniquet application. Interleukin-6 protein was detected in small-sized and medium-sized dorsal root ganglion cells by immunohistochemical analysis. The induction of interleukin-6 expression is likely to play a role in the protection of injured neurons perhaps related to growth of their axons. Glycoprotein 130 might also account for the inhibitory effects following nerve injury. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/16272873/A_hind_limb_tourniquet_induces_interleukin_6_expression_in_a_rat_dorsal_root_ganglion_ L2 - https://doi.org/10.1097/01.wnr.0000186600.73867.8a DB - PRIME DP - Unbound Medicine ER -