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Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort.
J Am Geriatr Soc. 2005 Nov; 53(11):1966-72.JA

Abstract

OBJECTIVES

To apply diagnostic criteria for mild cognitive impairment (MCI) to a geographically representative sample, to estimate the prevalence of MCI, and to estimate 10-year trajectories of incident disability for cognitively intact participants and subgroups with MCI.

DESIGN

Prospective cohort; 10 years of follow-up.

SETTING

Community-based survey of noninstitutionalized population aged 65 and or older in two rural Iowa counties (Washington and Iowa).

PARTICIPANTS

Iowa Established Populations for Epidemiologic Studies of the Elderly (aged > or = 65; N = 3,673; 61.3% female; 99.9% white).

MEASUREMENTS

Age, sex, education, Short Portable Mental Status Questionnaire (SPMSQ), 20-item word recall, activities of daily living (ADLs), instrumental activities of daily living (IADLs), chronic medical conditions.

RESULTS

MCI was prevalent in 24.7% of participants at baseline. Most participants in the overall cohort remained stable or changed slowly (< or = 1 new limitations) over 10 years (63.1% for SPMSQ, 89.3% for word recall, and 61.7% for ADL disability). For MCI/no prevalent IADL disability (Stage 1 MCI), disability progression was similar to that in the cognitively intact subgroup (median = 0.08 vs 0.05 disabilities per year). For MCI plus prevalent IADL disability (Stage 2 MCI), the median rate of change was equivalent to that of the severely impaired (0.23 disabilities per year; interquartile range = 0.12-0.36).

CONCLUSION

Unlike participants with MCI who reported no IADL limitations, those with such limitations were more likely to develop ADL disability--a prerequisite for a diagnosis of dementia.

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Authors+Show Affiliations

Purser JL
Division of Geriatrics, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. jlp@geri.duke.edu
Fillenbaum GG
No affiliation info available
Pieper CF
No affiliation info available
Wallace RB
No affiliation info available

MeSH

Activities of Daily LivingAgedAged, 80 and overAlzheimer DiseaseAmnesiaCognition DisordersCohort StudiesDisability EvaluationDisease ProgressionFemaleFollow-Up StudiesHealth SurveysHumansIowaLongitudinal StudiesMaleNeuropsychological TestsProbabilityPsychometrics

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16274380

Citation

Purser, Jama L., et al. "Mild Cognitive Impairment and 10-year Trajectories of Disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly Cohort." Journal of the American Geriatrics Society, vol. 53, no. 11, 2005, pp. 1966-72.
Purser JL, Fillenbaum GG, Pieper CF, et al. Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort. J Am Geriatr Soc. 2005;53(11):1966-72.
Purser, J. L., Fillenbaum, G. G., Pieper, C. F., & Wallace, R. B. (2005). Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort. Journal of the American Geriatrics Society, 53(11), 1966-72.
Purser JL, et al. Mild Cognitive Impairment and 10-year Trajectories of Disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly Cohort. J Am Geriatr Soc. 2005;53(11):1966-72. PubMed PMID: 16274380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort. AU - Purser,Jama L, AU - Fillenbaum,Gerda G, AU - Pieper,Carl F, AU - Wallace,Robert B, PY - 2005/11/9/pubmed PY - 2006/1/26/medline PY - 2005/11/9/entrez SP - 1966 EP - 72 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 53 IS - 11 N2 - OBJECTIVES: To apply diagnostic criteria for mild cognitive impairment (MCI) to a geographically representative sample, to estimate the prevalence of MCI, and to estimate 10-year trajectories of incident disability for cognitively intact participants and subgroups with MCI. DESIGN: Prospective cohort; 10 years of follow-up. SETTING: Community-based survey of noninstitutionalized population aged 65 and or older in two rural Iowa counties (Washington and Iowa). PARTICIPANTS: Iowa Established Populations for Epidemiologic Studies of the Elderly (aged > or = 65; N = 3,673; 61.3% female; 99.9% white). MEASUREMENTS: Age, sex, education, Short Portable Mental Status Questionnaire (SPMSQ), 20-item word recall, activities of daily living (ADLs), instrumental activities of daily living (IADLs), chronic medical conditions. RESULTS: MCI was prevalent in 24.7% of participants at baseline. Most participants in the overall cohort remained stable or changed slowly (< or = 1 new limitations) over 10 years (63.1% for SPMSQ, 89.3% for word recall, and 61.7% for ADL disability). For MCI/no prevalent IADL disability (Stage 1 MCI), disability progression was similar to that in the cognitively intact subgroup (median = 0.08 vs 0.05 disabilities per year). For MCI plus prevalent IADL disability (Stage 2 MCI), the median rate of change was equivalent to that of the severely impaired (0.23 disabilities per year; interquartile range = 0.12-0.36). CONCLUSION: Unlike participants with MCI who reported no IADL limitations, those with such limitations were more likely to develop ADL disability--a prerequisite for a diagnosis of dementia. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/16274380/Mild_cognitive_impairment_and_10_year_trajectories_of_disability_in_the_Iowa_Established_Populations_for_Epidemiologic_Studies_of_the_Elderly_cohort_ L2 - https://doi.org/10.1111/j.1532-5415.2005.53566.x DB - PRIME DP - Unbound Medicine ER -