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Seroprevalence of SARS coronavirus antibody in household contacts.
Epidemiol Infect. 2005 Dec; 133(6):1119-22.EI

Abstract

Between March and July 2003, 671 cases of severe acute respiratory syndrome (SARS) were diagnosed in Taiwan with a total of 84 fatalities. After the epidemic, a serological survey was conducted involving the asymptomatic household contacts. Household contacts of 13 index patients were enrolled in the study. Contact history and clinical symptoms of the household contacts were recorded by standardized questionnaires. Blood samples of patients and household contacts were collected at least 28 days after symptom onset in the index patients or household exposure in the contacts for SARS-associated coronavirus (SARS-CoV) IgG testing. On the basis of this investigation, 29 persons (25 adults and 4 children) were identified as having had unprotected exposure to the index cases before infection-control practices were implemented. Laboratory evaluation of clinical specimens showed no evidence of transmission of SARS-CoV infection to any contacts. This investigation demonstrated that subclinical transmission among household contacts was low in the described setting.

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Authors+Show Affiliations

Lee CC
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chen SY
No affiliation info available
Chang IJ
No affiliation info available
Tsai PC
No affiliation info available
Lu TC
No affiliation info available
Wu PL
No affiliation info available
Chen WJ
No affiliation info available
Huang LM
No affiliation info available
Chang SC
No affiliation info available

MeSH

AdultAntibodies, ViralContact TracingFemaleHumansImmunoglobulin GMaleMiddle AgedSevere acute respiratory syndrome-related coronavirusSeroepidemiologic StudiesSevere Acute Respiratory Syndrome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16274510

Citation

Lee, C-C, et al. "Seroprevalence of SARS Coronavirus Antibody in Household Contacts." Epidemiology and Infection, vol. 133, no. 6, 2005, pp. 1119-22.
Lee CC, Chen SY, Chang IJ, et al. Seroprevalence of SARS coronavirus antibody in household contacts. Epidemiol Infect. 2005;133(6):1119-22.
Lee, C. C., Chen, S. Y., Chang, I. J., Tsai, P. C., Lu, T. C., Wu, P. L., Chen, W. J., Huang, L. M., & Chang, S. C. (2005). Seroprevalence of SARS coronavirus antibody in household contacts. Epidemiology and Infection, 133(6), 1119-22.
Lee CC, et al. Seroprevalence of SARS Coronavirus Antibody in Household Contacts. Epidemiol Infect. 2005;133(6):1119-22. PubMed PMID: 16274510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroprevalence of SARS coronavirus antibody in household contacts. AU - Lee,C-C, AU - Chen,S-Y, AU - Chang,I-J, AU - Tsai,P-C, AU - Lu,T-C, AU - Wu,P-L, AU - Chen,W-J, AU - Huang,L-M, AU - Chang,S-C, PY - 2005/03/21/accepted PY - 2005/11/9/pubmed PY - 2006/2/8/medline PY - 2005/11/9/entrez SP - 1119 EP - 22 JF - Epidemiology and infection JO - Epidemiol Infect VL - 133 IS - 6 N2 - Between March and July 2003, 671 cases of severe acute respiratory syndrome (SARS) were diagnosed in Taiwan with a total of 84 fatalities. After the epidemic, a serological survey was conducted involving the asymptomatic household contacts. Household contacts of 13 index patients were enrolled in the study. Contact history and clinical symptoms of the household contacts were recorded by standardized questionnaires. Blood samples of patients and household contacts were collected at least 28 days after symptom onset in the index patients or household exposure in the contacts for SARS-associated coronavirus (SARS-CoV) IgG testing. On the basis of this investigation, 29 persons (25 adults and 4 children) were identified as having had unprotected exposure to the index cases before infection-control practices were implemented. Laboratory evaluation of clinical specimens showed no evidence of transmission of SARS-CoV infection to any contacts. This investigation demonstrated that subclinical transmission among household contacts was low in the described setting. SN - 0950-2688 UR - https://www.unboundmedicine.com/medline/citation/16274510/Seroprevalence_of_SARS_coronavirus_antibody_in_household_contacts_ DB - PRIME DP - Unbound Medicine ER -