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The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion.
Int Immunopharmacol. 2005 Dec; 5(13-14):1820-9.II

Abstract

The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. We investigated the effect of the gall of Rhus javanica (GRJ) on the model of the immediate-type allergic reaction, and studied its possible mechanisms. GRJ inhibited compound 48/80-induced systemic reactions in mice. GRJ attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, GRJ dose dependently decreased histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. The decreasing effect of GRJ on the histamine release was mediated by the modulation of cAMP and [Ca2+]i in mast cells. Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-alpha and IL-6 secretion in human mast cells. The inhibitory effect of GRJ on the pro-inflammatory cytokine was c-Jun N-terminal kinase and nuclear factor-kappaB dependent. Our findings provide evidence that GRJ inhibits mast cell-derived immediate-type allergic reactions, and suggest the possible mechanisms of action.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 700-422, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16275618

Citation

Kim, Sang-Hyun, et al. "The Anti-anaphylactic Effect of the Gall of Rhus Javanica Is Mediated Through Inhibition of Histamine Release and Inflammatory Cytokine Secretion." International Immunopharmacology, vol. 5, no. 13-14, 2005, pp. 1820-9.
Kim SH, Park HH, Lee S, et al. The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion. Int Immunopharmacol. 2005;5(13-14):1820-9.
Kim, S. H., Park, H. H., Lee, S., Jun, C. D., Choi, B. J., Kim, S. Y., Kim, S. H., Kim, D. K., Park, J. S., Chae, B. S., & Shin, T. Y. (2005). The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion. International Immunopharmacology, 5(13-14), 1820-9.
Kim SH, et al. The Anti-anaphylactic Effect of the Gall of Rhus Javanica Is Mediated Through Inhibition of Histamine Release and Inflammatory Cytokine Secretion. Int Immunopharmacol. 2005;5(13-14):1820-9. PubMed PMID: 16275618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion. AU - Kim,Sang-Hyun, AU - Park,Hyo-Hyun, AU - Lee,Soyoung, AU - Jun,Chang-Duk, AU - Choi,Byung-Ju, AU - Kim,Sang-Yong, AU - Kim,Sug-Hyun, AU - Kim,Dae-Keun, AU - Park,Jeong-Suk, AU - Chae,Byeong-Suk, AU - Shin,Tae-Yong, Y1 - 2005/06/23/ PY - 2005/04/11/received PY - 2005/04/21/revised PY - 2005/06/02/accepted PY - 2005/11/9/pubmed PY - 2006/9/23/medline PY - 2005/11/9/entrez SP - 1820 EP - 9 JF - International immunopharmacology JO - Int Immunopharmacol VL - 5 IS - 13-14 N2 - The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. We investigated the effect of the gall of Rhus javanica (GRJ) on the model of the immediate-type allergic reaction, and studied its possible mechanisms. GRJ inhibited compound 48/80-induced systemic reactions in mice. GRJ attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, GRJ dose dependently decreased histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. The decreasing effect of GRJ on the histamine release was mediated by the modulation of cAMP and [Ca2+]i in mast cells. Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-alpha and IL-6 secretion in human mast cells. The inhibitory effect of GRJ on the pro-inflammatory cytokine was c-Jun N-terminal kinase and nuclear factor-kappaB dependent. Our findings provide evidence that GRJ inhibits mast cell-derived immediate-type allergic reactions, and suggest the possible mechanisms of action. SN - 1567-5769 UR - https://www.unboundmedicine.com/medline/citation/16275618/The_anti_anaphylactic_effect_of_the_gall_of_Rhus_javanica_is_mediated_through_inhibition_of_histamine_release_and_inflammatory_cytokine_secretion_ DB - PRIME DP - Unbound Medicine ER -