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Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4.
Neurology. 2005 Nov 08; 65(9):1409-14.Neur

Abstract

OBJECTIVE

To compare associations of lean fish vs fatty fish (tuna or other fish) intake with dementia, Alzheimer disease (AD), and vascular dementia (VaD) and in relation to APOE epsilon4 status in the Cardiovascular Health Cognition Study (CHCS).

METHODS

Fish intake was assessed by food frequency questionnaires. Incident dementia, AD, and VaD were determined through a series of cognitive tests, physician's assessment, and committee consensus. We used Cox proportional hazards regression to calculate hazard ratios of dementia, AD, and VaD with lean fried fish, fatty fish, or total fish intake, which were then stratified by the presence of APOE epsilon4.

RESULTS

Although consumption of lean fried fish had no protective effect, consumption of fatty fish more than twice per week was associated with a reduction in risk of dementia by 28% (95% CI: 0.51 to 1.02), and AD by 41% (95% CI: 0.36 to 0.95) in comparison to those who ate fish less than once per month. Stratification by APOE epsilon4 showed this effect to be selective to those without the epsilon4 allele. Adjustment by education and income attenuated the effect.

CONCLUSION

In the Cardiovascular Health Cognition Study, consumption of fatty fish was associated with a reduced risk of dementia and Alzheimer disease for those without the APOE epsilon4 allele.

Authors+Show Affiliations

Huang TL
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. tina.huang@tufts.edu
Zandi PP
No affiliation info available
Tucker KL
No affiliation info available
Fitzpatrick AL
No affiliation info available
Kuller LH
No affiliation info available
Fried LP
No affiliation info available
Burke GL
No affiliation info available
Carlson MC
No affiliation info available

MeSH

AgedAlzheimer DiseaseApolipoprotein E4Apolipoproteins ECohort StudiesDementiaDietary Fats, UnsaturatedFatty Acids, Omega-3Feeding BehaviorFemaleFish OilsFish ProductsFood, FormulatedGenetic Predisposition to DiseaseHumansIncidenceMaleRisk FactorsSocioeconomic FactorsSurveys and Questionnaires

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16275829

Citation

Huang, T L., et al. "Benefits of Fatty Fish On Dementia Risk Are Stronger for Those Without APOE Epsilon4." Neurology, vol. 65, no. 9, 2005, pp. 1409-14.
Huang TL, Zandi PP, Tucker KL, et al. Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology. 2005;65(9):1409-14.
Huang, T. L., Zandi, P. P., Tucker, K. L., Fitzpatrick, A. L., Kuller, L. H., Fried, L. P., Burke, G. L., & Carlson, M. C. (2005). Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology, 65(9), 1409-14.
Huang TL, et al. Benefits of Fatty Fish On Dementia Risk Are Stronger for Those Without APOE Epsilon4. Neurology. 2005 Nov 8;65(9):1409-14. PubMed PMID: 16275829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. AU - Huang,T L, AU - Zandi,P P, AU - Tucker,K L, AU - Fitzpatrick,A L, AU - Kuller,L H, AU - Fried,L P, AU - Burke,G L, AU - Carlson,M C, PY - 2005/11/9/pubmed PY - 2006/4/13/medline PY - 2005/11/9/entrez SP - 1409 EP - 14 JF - Neurology JO - Neurology VL - 65 IS - 9 N2 - OBJECTIVE: To compare associations of lean fish vs fatty fish (tuna or other fish) intake with dementia, Alzheimer disease (AD), and vascular dementia (VaD) and in relation to APOE epsilon4 status in the Cardiovascular Health Cognition Study (CHCS). METHODS: Fish intake was assessed by food frequency questionnaires. Incident dementia, AD, and VaD were determined through a series of cognitive tests, physician's assessment, and committee consensus. We used Cox proportional hazards regression to calculate hazard ratios of dementia, AD, and VaD with lean fried fish, fatty fish, or total fish intake, which were then stratified by the presence of APOE epsilon4. RESULTS: Although consumption of lean fried fish had no protective effect, consumption of fatty fish more than twice per week was associated with a reduction in risk of dementia by 28% (95% CI: 0.51 to 1.02), and AD by 41% (95% CI: 0.36 to 0.95) in comparison to those who ate fish less than once per month. Stratification by APOE epsilon4 showed this effect to be selective to those without the epsilon4 allele. Adjustment by education and income attenuated the effect. CONCLUSION: In the Cardiovascular Health Cognition Study, consumption of fatty fish was associated with a reduced risk of dementia and Alzheimer disease for those without the APOE epsilon4 allele. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16275829/Benefits_of_fatty_fish_on_dementia_risk_are_stronger_for_those_without_APOE_epsilon4_ DB - PRIME DP - Unbound Medicine ER -