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Excessive daytime sleepiness and subsequent development of Parkinson disease.
Neurology. 2005 Nov 08; 65(9):1442-6.Neur

Abstract

OBJECTIVE

To determine if excessive daytime sleepiness (EDS) can predate future Parkinson disease (PD).

METHODS

EDS was assessed in 3,078 men aged 71 to 93 years in the Honolulu-Asia Aging Study from 1991 to 1993. All were free of prevalent PD and dementia. Follow-up for incident PD was based on three repeat neurologic assessments from 1994 to 2001.

RESULTS

During the course of follow-up, 43 men developed PD (19.9/10,000 person-years). After age adjustment, there was more than a threefold excess in the risk of PD in men with EDS vs men without EDS (55.3 vs 17.0/10,000 person-years; odds ratio [OR] = 3.3; 95% CI = 1.4 to 7.0; p = 0.004). Additional adjustment for insomnia, cognitive function, depressed mood, midlife cigarette smoking and coffee drinking, and other factors failed to alter the association between EDS and PD (OR = 2.8; 95% CI = 1.1 to 6.4; p = 0.014). Other sleep related features such as insomnia, daytime napping, early morning grogginess, and frequent nocturnal awakening showed little relation with the risk of PD.

CONCLUSIONS

Excessive daytime sleepiness may be associated with an increased risk of developing Parkinson disease.

Authors+Show Affiliations

Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, VA, USA. rda3e@virginia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16275833

Citation

Abbott, R D., et al. "Excessive Daytime Sleepiness and Subsequent Development of Parkinson Disease." Neurology, vol. 65, no. 9, 2005, pp. 1442-6.
Abbott RD, Ross GW, White LR, et al. Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology. 2005;65(9):1442-6.
Abbott, R. D., Ross, G. W., White, L. R., Tanner, C. M., Masaki, K. H., Nelson, J. S., Curb, J. D., & Petrovitch, H. (2005). Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology, 65(9), 1442-6.
Abbott RD, et al. Excessive Daytime Sleepiness and Subsequent Development of Parkinson Disease. Neurology. 2005 Nov 8;65(9):1442-6. PubMed PMID: 16275833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Excessive daytime sleepiness and subsequent development of Parkinson disease. AU - Abbott,R D, AU - Ross,G W, AU - White,L R, AU - Tanner,C M, AU - Masaki,K H, AU - Nelson,J S, AU - Curb,J D, AU - Petrovitch,H, PY - 2005/11/9/pubmed PY - 2006/4/13/medline PY - 2005/11/9/entrez SP - 1442 EP - 6 JF - Neurology JO - Neurology VL - 65 IS - 9 N2 - OBJECTIVE: To determine if excessive daytime sleepiness (EDS) can predate future Parkinson disease (PD). METHODS: EDS was assessed in 3,078 men aged 71 to 93 years in the Honolulu-Asia Aging Study from 1991 to 1993. All were free of prevalent PD and dementia. Follow-up for incident PD was based on three repeat neurologic assessments from 1994 to 2001. RESULTS: During the course of follow-up, 43 men developed PD (19.9/10,000 person-years). After age adjustment, there was more than a threefold excess in the risk of PD in men with EDS vs men without EDS (55.3 vs 17.0/10,000 person-years; odds ratio [OR] = 3.3; 95% CI = 1.4 to 7.0; p = 0.004). Additional adjustment for insomnia, cognitive function, depressed mood, midlife cigarette smoking and coffee drinking, and other factors failed to alter the association between EDS and PD (OR = 2.8; 95% CI = 1.1 to 6.4; p = 0.014). Other sleep related features such as insomnia, daytime napping, early morning grogginess, and frequent nocturnal awakening showed little relation with the risk of PD. CONCLUSIONS: Excessive daytime sleepiness may be associated with an increased risk of developing Parkinson disease. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16275833/Excessive_daytime_sleepiness_and_subsequent_development_of_Parkinson_disease_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16275833 DB - PRIME DP - Unbound Medicine ER -