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[A 73-year-old woman with depression, dementia, and parkinsonism].
No To Shinkei. 2005 Oct; 57(10):907-14.NT

Abstract

We report a 73-year-old woman who had depression, dementia, and parkinsonism. She had postural tremor since her fortics. She was losing her weight since age 66 years. She noted difficulty in walk at age 72 (2001). She could not stand without assistance on July 2001, and she became hypobulic. On admission to our hospital on November 2001, she had dementia and revised Hasegawa dementia scale (HDS-R) was 8/30. She had mild limitation of the upward gaze, and rigidity in the neck, but not in the limbs. Postural tremor was seen. No muscle weakness was noted and tendon reflexes were normal. She was treated with levodopa/carvidopa, but she did not improve. She did not eat much. She was transferred to another hospital and she suddenly died on January 2002. The patient was discussed in a neurological CPC, and a chief discussant arrived at a conclusion that the patient had Parkinson disease with dementia. Some participants thought the diagnosis was progressive supranuclear palsy or diffuse Lewy body disease. The examination at autopsy revealed mild neuronal loss and Lewy bodies in the substantia nigra. Many Lewy bodies were observed in the cerebral cortex which corresponded to the neocortical type of DLB, and Lewy neurites were seen in the CA2 of the hippocampus by immunohistochemistry for alpha-synuclein. Spongy change was seen in the parahippocampus. Pathological diagnosis was diffuse Lewy body disease.

Authors+Show Affiliations

Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Clinical Conference
English Abstract
Journal Article

Language

jpn

PubMed ID

16277238

Citation

Hatano, Taku, et al. "[A 73-year-old Woman With Depression, Dementia, and Parkinsonism]." No to Shinkei = Brain and Nerve, vol. 57, no. 10, 2005, pp. 907-14.
Hatano T, Takanashi M, Sumino T, et al. [A 73-year-old woman with depression, dementia, and parkinsonism]. No To Shinkei. 2005;57(10):907-14.
Hatano, T., Takanashi, M., Sumino, T., Liu, Y., Mori, H., Hattori, N., & Mizuno, Y. (2005). [A 73-year-old woman with depression, dementia, and parkinsonism]. No to Shinkei = Brain and Nerve, 57(10), 907-14.
Hatano T, et al. [A 73-year-old Woman With Depression, Dementia, and Parkinsonism]. No To Shinkei. 2005;57(10):907-14. PubMed PMID: 16277238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A 73-year-old woman with depression, dementia, and parkinsonism]. AU - Hatano,Taku, AU - Takanashi,Masashi, AU - Sumino,Teiko, AU - Liu,Ying, AU - Mori,Hideo, AU - Hattori,Nobutaka, AU - Mizuno,Yoshikuni, PY - 2005/11/10/pubmed PY - 2005/12/13/medline PY - 2005/11/10/entrez SP - 907 EP - 14 JF - No to shinkei = Brain and nerve JO - No To Shinkei VL - 57 IS - 10 N2 - We report a 73-year-old woman who had depression, dementia, and parkinsonism. She had postural tremor since her fortics. She was losing her weight since age 66 years. She noted difficulty in walk at age 72 (2001). She could not stand without assistance on July 2001, and she became hypobulic. On admission to our hospital on November 2001, she had dementia and revised Hasegawa dementia scale (HDS-R) was 8/30. She had mild limitation of the upward gaze, and rigidity in the neck, but not in the limbs. Postural tremor was seen. No muscle weakness was noted and tendon reflexes were normal. She was treated with levodopa/carvidopa, but she did not improve. She did not eat much. She was transferred to another hospital and she suddenly died on January 2002. The patient was discussed in a neurological CPC, and a chief discussant arrived at a conclusion that the patient had Parkinson disease with dementia. Some participants thought the diagnosis was progressive supranuclear palsy or diffuse Lewy body disease. The examination at autopsy revealed mild neuronal loss and Lewy bodies in the substantia nigra. Many Lewy bodies were observed in the cerebral cortex which corresponded to the neocortical type of DLB, and Lewy neurites were seen in the CA2 of the hippocampus by immunohistochemistry for alpha-synuclein. Spongy change was seen in the parahippocampus. Pathological diagnosis was diffuse Lewy body disease. SN - 0006-8969 UR - https://www.unboundmedicine.com/medline/citation/16277238/[A_73_year_old_woman_with_depression_dementia_and_parkinsonism]_ L2 - https://webview.isho.jp/openurl?rft.genre=article&rft.issn=0006-8969&rft.volume=57&rft.issue=10&rft.spage=907 DB - PRIME DP - Unbound Medicine ER -