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Role of diet in prostate cancer development and progression.
J Clin Oncol 2005; 23(32):8152-60JC

Abstract

Increasing evidence supports the important role of nutrition in cancer prevention, including prevention of prostate cancer. In this review, we summarize data for some of the most consistently observed dietary associations for prostate cancer incidence, briefly consider possible postdiagnostic effects of nutrition on prostate cancer progression/survival, discuss new but limited data on diet-gene interactions, and comment on current areas of controversy for future research focus. Potential protective dietary elements include tomatoes/lycopene, other carotenoids, cruciferous vegetables, vitamin E, selenium, fish/marine omega-3 fatty acids, soy, isoflavones and polyphenols; whereas milk, dairy, calcium, zinc at high doses, saturated fat, grilled meats, and heterocyclic amines may increase risk. It is important to note that randomized clinical trial data exist only for vitamin E, calcium, beta-carotene, and selenium (all of which suggest inverse or no association). Several genes, such as MnSOD, XRCC1, and GST, may modify the association of specific nutrients and foods with prostate cancer risk; and further research is warranted to confirm these initial observed relationships. Until further clinical trial data are available on specific supplements and prostate cancer prevention, it would be prudent to emphasize a diet consisting of a wide variety of plant-based foods and fish; this is similar to what is recommended (and what is more well established) for the primary prevention of heart disease.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, 1600 Divisadero St, Box 1695, San Francisco, CA 94143-1695, USA. june@uorg.ucsf.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16278466

Citation

Chan, June M., et al. "Role of Diet in Prostate Cancer Development and Progression." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 23, no. 32, 2005, pp. 8152-60.
Chan JM, Gann PH, Giovannucci EL. Role of diet in prostate cancer development and progression. J Clin Oncol. 2005;23(32):8152-60.
Chan, J. M., Gann, P. H., & Giovannucci, E. L. (2005). Role of diet in prostate cancer development and progression. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 23(32), pp. 8152-60.
Chan JM, Gann PH, Giovannucci EL. Role of Diet in Prostate Cancer Development and Progression. J Clin Oncol. 2005 Nov 10;23(32):8152-60. PubMed PMID: 16278466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of diet in prostate cancer development and progression. AU - Chan,June M, AU - Gann,Peter H, AU - Giovannucci,Edward L, PY - 2005/11/10/pubmed PY - 2005/12/29/medline PY - 2005/11/10/entrez SP - 8152 EP - 60 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J. Clin. Oncol. VL - 23 IS - 32 N2 - Increasing evidence supports the important role of nutrition in cancer prevention, including prevention of prostate cancer. In this review, we summarize data for some of the most consistently observed dietary associations for prostate cancer incidence, briefly consider possible postdiagnostic effects of nutrition on prostate cancer progression/survival, discuss new but limited data on diet-gene interactions, and comment on current areas of controversy for future research focus. Potential protective dietary elements include tomatoes/lycopene, other carotenoids, cruciferous vegetables, vitamin E, selenium, fish/marine omega-3 fatty acids, soy, isoflavones and polyphenols; whereas milk, dairy, calcium, zinc at high doses, saturated fat, grilled meats, and heterocyclic amines may increase risk. It is important to note that randomized clinical trial data exist only for vitamin E, calcium, beta-carotene, and selenium (all of which suggest inverse or no association). Several genes, such as MnSOD, XRCC1, and GST, may modify the association of specific nutrients and foods with prostate cancer risk; and further research is warranted to confirm these initial observed relationships. Until further clinical trial data are available on specific supplements and prostate cancer prevention, it would be prudent to emphasize a diet consisting of a wide variety of plant-based foods and fish; this is similar to what is recommended (and what is more well established) for the primary prevention of heart disease. SN - 0732-183X UR - https://www.unboundmedicine.com/medline/citation/16278466/Role_of_diet_in_prostate_cancer_development_and_progression_ L2 - http://ascopubs.org/doi/full/10.1200/JCO.2005.03.1492?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -