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New weakly expressed cell cycle-regulated genes in yeast.
Yeast. 2005 Nov; 22(15):1191-201.Y

Abstract

We present an approach combining bioinformatics prediction with experimental microarray validation to identify new cell cycle-regulated genes in Saccharomyces cerevisiae. We identify in the order of 100 new cell cycle-regulated genes and show by independent data that these genes in general tend to be more weakly expressed than the genes identified hitherto. Among the genes not previously suggested to be periodically expressed we find genes linked to DNA repair, cell size monitoring and transcriptional control, as well as a number of genes of unknown function. Several of the gene products are believed to be phosphorylated by Cdc28. For many of these new genes, homologues exist in Schizosaccharomyces pombe and Homo sapiens for which the expression also varies with cell cycle progression.

Authors+Show Affiliations

Center for Biological Sequence Analysis, BioCentrum, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16278933

Citation

de Lichtenberg, Ulrik, et al. "New Weakly Expressed Cell Cycle-regulated Genes in Yeast." Yeast (Chichester, England), vol. 22, no. 15, 2005, pp. 1191-201.
de Lichtenberg U, Wernersson R, Jensen TS, et al. New weakly expressed cell cycle-regulated genes in yeast. Yeast. 2005;22(15):1191-201.
de Lichtenberg, U., Wernersson, R., Jensen, T. S., Nielsen, H. B., Fausbøll, A., Schmidt, P., Hansen, F. B., Knudsen, S., & Brunak, S. (2005). New weakly expressed cell cycle-regulated genes in yeast. Yeast (Chichester, England), 22(15), 1191-201.
de Lichtenberg U, et al. New Weakly Expressed Cell Cycle-regulated Genes in Yeast. Yeast. 2005;22(15):1191-201. PubMed PMID: 16278933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New weakly expressed cell cycle-regulated genes in yeast. AU - de Lichtenberg,Ulrik, AU - Wernersson,Rasmus, AU - Jensen,Thomas Skøt, AU - Nielsen,Henrik Bjørn, AU - Fausbøll,Anders, AU - Schmidt,Peer, AU - Hansen,Flemming Bryde, AU - Knudsen,Steen, AU - Brunak,Søren, PY - 2005/11/10/pubmed PY - 2006/1/6/medline PY - 2005/11/10/entrez SP - 1191 EP - 201 JF - Yeast (Chichester, England) JO - Yeast VL - 22 IS - 15 N2 - We present an approach combining bioinformatics prediction with experimental microarray validation to identify new cell cycle-regulated genes in Saccharomyces cerevisiae. We identify in the order of 100 new cell cycle-regulated genes and show by independent data that these genes in general tend to be more weakly expressed than the genes identified hitherto. Among the genes not previously suggested to be periodically expressed we find genes linked to DNA repair, cell size monitoring and transcriptional control, as well as a number of genes of unknown function. Several of the gene products are believed to be phosphorylated by Cdc28. For many of these new genes, homologues exist in Schizosaccharomyces pombe and Homo sapiens for which the expression also varies with cell cycle progression. SN - 0749-503X UR - https://www.unboundmedicine.com/medline/citation/16278933/New_weakly_expressed_cell_cycle_regulated_genes_in_yeast_ L2 - https://doi.org/10.1002/yea.1302 DB - PRIME DP - Unbound Medicine ER -