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The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese.
Thyroid. 2005 Oct; 15(10):1115-8.T

Abstract

The etiology of the autoimmune thyroid diseases (AITDs), Graves' disease (GD), and Hashimoto's thyroiditis (HT) is largely unknown. However, genetic susceptibility is believed to play a major role. The lymphoid tyrosine phosphatase (LYP), encoded by the protein tyrosine phosphatase-22 (PTPN22) gene, is a powerful inhibitor of T cell activation. Recently, a single-nucleotide polymorphism (SNP), encoding a functional arginine to tryptophan residue change at PTPN22 codon 620 in Caucasians has been shown to be associated with GD and other autoimmune diseases. We have used a polymerase chain reaction (PCR)-restriction fragment (XcmI) assay to examine genotypes at the codon 620 polymorphism in 334 unrelated patients with AITD and 179 controls. None of the patients with AITD and controls had the tryptophan allele. These data suggest that the codon 620 polymorphism of the PTPN22 gene does not have a causal role for AITD in the Japanese. However, we cannot exclude the PTPN22 region as harboring another susceptibility locus for AITD in linkage disequilibrium with the Trp/Arg SNP.

Authors+Show Affiliations

Third Department of Internal Medicine, Tokyo, Japan. yshyban@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16279843

Citation

Ban, Yoshiyuki, et al. "The Codon 620 Single Nucleotide Polymorphism of the Protein Tyrosine Phosphatase-22 Gene Does Not Contribute to Autoimmune Thyroid Disease Susceptibility in the Japanese." Thyroid : Official Journal of the American Thyroid Association, vol. 15, no. 10, 2005, pp. 1115-8.
Ban Y, Tozaki T, Taniyama M, et al. The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese. Thyroid. 2005;15(10):1115-8.
Ban, Y., Tozaki, T., Taniyama, M., Tomita, M., & Ban, Y. (2005). The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese. Thyroid : Official Journal of the American Thyroid Association, 15(10), 1115-8.
Ban Y, et al. The Codon 620 Single Nucleotide Polymorphism of the Protein Tyrosine Phosphatase-22 Gene Does Not Contribute to Autoimmune Thyroid Disease Susceptibility in the Japanese. Thyroid. 2005;15(10):1115-8. PubMed PMID: 16279843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese. AU - Ban,Yoshiyuki, AU - Tozaki,Teruaki, AU - Taniyama,Matsuo, AU - Tomita,Motowo, AU - Ban,Yoshio, PY - 2005/11/11/pubmed PY - 2006/3/11/medline PY - 2005/11/11/entrez SP - 1115 EP - 8 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 15 IS - 10 N2 - The etiology of the autoimmune thyroid diseases (AITDs), Graves' disease (GD), and Hashimoto's thyroiditis (HT) is largely unknown. However, genetic susceptibility is believed to play a major role. The lymphoid tyrosine phosphatase (LYP), encoded by the protein tyrosine phosphatase-22 (PTPN22) gene, is a powerful inhibitor of T cell activation. Recently, a single-nucleotide polymorphism (SNP), encoding a functional arginine to tryptophan residue change at PTPN22 codon 620 in Caucasians has been shown to be associated with GD and other autoimmune diseases. We have used a polymerase chain reaction (PCR)-restriction fragment (XcmI) assay to examine genotypes at the codon 620 polymorphism in 334 unrelated patients with AITD and 179 controls. None of the patients with AITD and controls had the tryptophan allele. These data suggest that the codon 620 polymorphism of the PTPN22 gene does not have a causal role for AITD in the Japanese. However, we cannot exclude the PTPN22 region as harboring another susceptibility locus for AITD in linkage disequilibrium with the Trp/Arg SNP. SN - 1050-7256 UR - https://www.unboundmedicine.com/medline/citation/16279843/The_codon_620_single_nucleotide_polymorphism_of_the_protein_tyrosine_phosphatase_22_gene_does_not_contribute_to_autoimmune_thyroid_disease_susceptibility_in_the_Japanese_ L2 - https://www.liebertpub.com/doi/full/10.1089/thy.2005.15.1115?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -