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Reducing the duration of untreated first-episode psychosis -- effects on baseline social functioning and quality of life.
Acta Psychiatr Scand. 2005 Dec; 112(6):469-73.AP

Abstract

OBJECTIVE

Long duration of untreated psychosis (DUP) is associated with poorer outcome. The TIPS study demonstrated that DUP can be reduced through early detection (ED). As quality of life (QoL) is associated with DUP it is expected that reduction of DUP leads to better QoL.

METHOD

Consecutive first-episode patients with a DSM-IV diagnosis of non-organic, non-affective psychosis were included, 281 patients gave informed consent and 263 completed a full evaluation of QoL.

RESULTS

There were no differences in subjective QoL between ED and No-ED groups attributable to reduction in DUP. There were significant bivariate differences in frequency of family and social contacts in favor of the ED group, but multivariate analyses indicated that these differences were based on differences in sample characteristics.

CONCLUSION

Deterioration in QoL may precede overt symptom formation. Focus on functional loss in ED educational campaigns may identify risk subjects earlier in the course of the disorder.

Authors+Show Affiliations

Department of Psychiatry, Yale University, New Haven, CT, USA. ingri.melle@medisin.uio.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16279877

Citation

Melle, I, et al. "Reducing the Duration of Untreated First-episode Psychosis -- Effects On Baseline Social Functioning and Quality of Life." Acta Psychiatrica Scandinavica, vol. 112, no. 6, 2005, pp. 469-73.
Melle I, Haahr U, Friis S, et al. Reducing the duration of untreated first-episode psychosis -- effects on baseline social functioning and quality of life. Acta Psychiatr Scand. 2005;112(6):469-73.
Melle, I., Haahr, U., Friis, S., Hustoft, K., Johannessen, J. O., Larsen, T. K., Opjordsmoen, S., Rund, B. R., Simonsen, E., Vaglum, P., & McGlashan, T. (2005). Reducing the duration of untreated first-episode psychosis -- effects on baseline social functioning and quality of life. Acta Psychiatrica Scandinavica, 112(6), 469-73.
Melle I, et al. Reducing the Duration of Untreated First-episode Psychosis -- Effects On Baseline Social Functioning and Quality of Life. Acta Psychiatr Scand. 2005;112(6):469-73. PubMed PMID: 16279877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reducing the duration of untreated first-episode psychosis -- effects on baseline social functioning and quality of life. AU - Melle,I, AU - Haahr,U, AU - Friis,S, AU - Hustoft,K, AU - Johannessen,J O, AU - Larsen,T K, AU - Opjordsmoen,S, AU - Rund,B R, AU - Simonsen,E, AU - Vaglum,P, AU - McGlashan,T, PY - 2005/11/11/pubmed PY - 2006/1/20/medline PY - 2005/11/11/entrez SP - 469 EP - 73 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 112 IS - 6 N2 - OBJECTIVE: Long duration of untreated psychosis (DUP) is associated with poorer outcome. The TIPS study demonstrated that DUP can be reduced through early detection (ED). As quality of life (QoL) is associated with DUP it is expected that reduction of DUP leads to better QoL. METHOD: Consecutive first-episode patients with a DSM-IV diagnosis of non-organic, non-affective psychosis were included, 281 patients gave informed consent and 263 completed a full evaluation of QoL. RESULTS: There were no differences in subjective QoL between ED and No-ED groups attributable to reduction in DUP. There were significant bivariate differences in frequency of family and social contacts in favor of the ED group, but multivariate analyses indicated that these differences were based on differences in sample characteristics. CONCLUSION: Deterioration in QoL may precede overt symptom formation. Focus on functional loss in ED educational campaigns may identify risk subjects earlier in the course of the disorder. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/16279877/Reducing_the_duration_of_untreated_first_episode_psychosis____effects_on_baseline_social_functioning_and_quality_of_life_ L2 - https://doi.org/10.1111/j.1600-0447.2005.00638.x DB - PRIME DP - Unbound Medicine ER -