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An overview of the central control of weight regulation and the effect of antipsychotic medication.
J Psychopharmacol. 2005 Nov; 19(6 Suppl):36-46.JP

Abstract

Weight regulation is a complex system necessary for maintaining health. Obesity and cachexia are consequences of dysregulation and cause significant physical morbidity and mortality. In the developed world, obesity is a growing epidemic. A greater understanding of the neuroanatomy of weight regulation has been gained through advances in imaging and neural mapping techniques. The neural connections between key hypothalamic and other central nuclei have been elucidated. Advances in molecular biology have led to the identification and cloning of important peripheral and central weight regulating peptides. Weight gain as a consequence of antipsychotic use is increasingly being recognized as a serious clinical issue. The weight regulation system provides a framework upon which antipsychotics exert their weight-inducing effects. Some studies have sought, with inconsistent results, to establish associations between antipsychotic use and levels of weight regulating mediators. The receptor pharmacology of antipsychotics known to increase weight can be studied with a view to establishing genetic variants contributing to the risk. To date, the 5-HT(2C) receptor 759C/T polymorphism shows most promise. Further studies are required to replicate previous findings and establish new associations.

Authors+Show Affiliations

Alimentary Pharmacobiotic Centre and Department of Psychiatry, University College Cork, Cork, Ireland.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16280336

Citation

Tighe, Sheila, and Timothy Dinan. "An Overview of the Central Control of Weight Regulation and the Effect of Antipsychotic Medication." Journal of Psychopharmacology (Oxford, England), vol. 19, no. 6 Suppl, 2005, pp. 36-46.
Tighe S, Dinan T. An overview of the central control of weight regulation and the effect of antipsychotic medication. J Psychopharmacol. 2005;19(6 Suppl):36-46.
Tighe, S., & Dinan, T. (2005). An overview of the central control of weight regulation and the effect of antipsychotic medication. Journal of Psychopharmacology (Oxford, England), 19(6 Suppl), 36-46.
Tighe S, Dinan T. An Overview of the Central Control of Weight Regulation and the Effect of Antipsychotic Medication. J Psychopharmacol. 2005;19(6 Suppl):36-46. PubMed PMID: 16280336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An overview of the central control of weight regulation and the effect of antipsychotic medication. AU - Tighe,Sheila, AU - Dinan,Timothy, PY - 2005/11/11/pubmed PY - 2009/11/6/medline PY - 2005/11/11/entrez SP - 36 EP - 46 JF - Journal of psychopharmacology (Oxford, England) JO - J Psychopharmacol VL - 19 IS - 6 Suppl N2 - Weight regulation is a complex system necessary for maintaining health. Obesity and cachexia are consequences of dysregulation and cause significant physical morbidity and mortality. In the developed world, obesity is a growing epidemic. A greater understanding of the neuroanatomy of weight regulation has been gained through advances in imaging and neural mapping techniques. The neural connections between key hypothalamic and other central nuclei have been elucidated. Advances in molecular biology have led to the identification and cloning of important peripheral and central weight regulating peptides. Weight gain as a consequence of antipsychotic use is increasingly being recognized as a serious clinical issue. The weight regulation system provides a framework upon which antipsychotics exert their weight-inducing effects. Some studies have sought, with inconsistent results, to establish associations between antipsychotic use and levels of weight regulating mediators. The receptor pharmacology of antipsychotics known to increase weight can be studied with a view to establishing genetic variants contributing to the risk. To date, the 5-HT(2C) receptor 759C/T polymorphism shows most promise. Further studies are required to replicate previous findings and establish new associations. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/16280336/An_overview_of_the_central_control_of_weight_regulation_and_the_effect_of_antipsychotic_medication_ L2 - https://journals.sagepub.com/doi/10.1177/0269881105058679?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -